Skip to main content
SpringerLink
Log in

Affinity of Drugs to the Different Renal Transporters for Organic Anions and Organic Cations

In Situ K i Values

  • Chapter
Membrane Transporters as Drug Targets

Part of the book series: Pharmaceutical Biotechnology ((PBIO,volume 12))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ammer, U., Natochin, Y., and Ullrich, K. J., 1993a, Tissue concentration and urinary excretion pattern of sulfofluorescein by the rat kidney, J. Am. Soc. Nephrol. 3:1474–1487.

    PubMed  CAS  Google Scholar 

  • Ammer, U., Natochin, Y., David, C. Rumrich, G., and Ullrich, K. J., 1993b, Cisplatin nephrotoxicity: Site of functional disturbance and correlation to loss of body weight, Renal Physiol. Biochem. 16:131–145.

    PubMed  CAS  Google Scholar 

  • Bergwerk, A. J., Shi, X., Ford, A. C., Kanai, N., Jacquemin, E., Burk, R. D., Bai, S., Novikoff, P. M., Stieger, B., Meier, P. J., Schuster, V. L., and Wolkoff, A. W., 1996, Immunologic distribution of an organic anion transport protein in rat liver and kidney, Am. J. Physiol. 271:G231–G238.

    PubMed  CAS  Google Scholar 

  • Brändle, E., Fritzsch, G., and Greven, J., 1992, Affinity of different local anesthetic drugs and catecholamines for the contraluminal transport system for organic cations in proximal tubules of rat kidneys, J. Pharmacol. Exp. Ther. 260:734–741.

    PubMed  Google Scholar 

  • Burckhardt, G, Schmitt, Ch., and Ullrich, K. J., 1991, p-Aminohippurate uptake across the basolateral membrane of rat proximal tubule cells: Specificity and mode of energetization, in: Proceedings of the 11th International Congress of Neophrology (M. Hatano et al., eds.), Springer-Verlag, Tokyo, vol. 2, pp. 1380–1390.

    Google Scholar 

  • Burckhardt, G., Porth, J., and Wolff, N. A., 1998, Functional and molecular characterizaton of the renal transporter for p-aminohippurate, Nova Acta Leopoldina NF 78:35–40.

    CAS  Google Scholar 

  • Busch, A. E., Schuster, A., Waldegger, S., Wagner, C. A., Zempel, G., Broer, S., Biber, J., Murer, H., and Lang, F., 1996, Expression of a renal type I sodium/phosphate transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions, Proc. Natl. Acad Sci. USA 93: 5347–5351.

    Article  PubMed  CAS  Google Scholar 

  • Chen, X., Tsukaguchi, H., Chen, X.-Z., Berger, U. V., and Hediger, M. A., 1999, Molecular and functional analysis of SCDT2, a novel rat sodium-dependent dicarboxylate transporter, J. Clin. Invest. 103: 1159–1168.

    Article  PubMed  CAS  Google Scholar 

  • David, C., Rumrich, G., and Ullrich, K. J., 1995, Luminal transport system for H+/organic cations in the rat proximal tubule: Kinetics, dependence on pH; specificity as compared with the contraluminal organic cation-transport system, Pfluegers Arch. 430:477–492.

    Article  CAS  Google Scholar 

  • Dettli, L., 1996, Grundlagen der Arzneimitteltherapie, 14th edition, Documed, Basel, in: “Allgemeine und spezielle Pharmakologie und Toxikologie”. 7th edition 1998, W. Forth, D. Henschler W. Rummel, and K. Starke eds). Spektrum Akademischer Verlag Heidelberg, Berlin, Oxford, pp. 94–101.

    Google Scholar 

  • Evers, R., Zaman, G. J. R., Van Deemter, L., Jansen, H., Calafat, J., Oomen L. C. J. M., Oude-Elferink, R. P. J., Borst, P., and Schinkerl A. H., 1996, Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells, J. Clin. Invest. 97:1211–1218.

    Article  PubMed  CAS  Google Scholar 

  • Fleck, Ch., 1998, Renal and hepatic transport, Nova Acta Leopoldina 78: 371 pages.

    Google Scholar 

  • Fritzsch, G., Rumrich, G., and Ullrich, K. J., 1989, Anion transport through the contraluminal cell membrane of renal proximal tubule. The influence of hydrophobicity and molecular charge distribution on the inhibitory activity of organic anions, Biochim. Biophys. Acta 978: 249–256.

    Article  PubMed  CAS  Google Scholar 

  • Gründemann, D., Gorboulev, V., Gambarian, S., Veyhl, M., and Koepsell, H., 1994, Drug excretion by a new prototype of polyspecific transporter, Nature 372:549–552.

    Article  PubMed  Google Scholar 

  • Gründemann, D., Babin-Ebell, J., Martel, F., Örding, N., Schmitt, A., and Schömig E., 1997, Primary structure and functional expression of the apical organic cation tansporter from rat kidney epithelial LLC-PK1 cells, J. Biol. Chem. 272:10408–10413.

    Article  PubMed  Google Scholar 

  • Hagenbuch, B., Echhardt, U., Noé, B., Stieger, B., and Meier, P. 1998, Multispecific hepatocellular bile acid and organic anion uptake systems, Nova Acta Leopoldina NF 78:129–133.

    CAS  Google Scholar 

  • Hästbacka, J., de la Chapelle, A., Mahtani, M. M., Clines, G., Reeve-Daly, M. P., Daly, M., Hamilton, B. A., Kusumi, K., Trivedi, B., Weaver, A., Coloma, A., Lovett, M. Buckler, A., Kaitila, I., and Lander E. S., 1994, The diastrophic dysplasia gene encodes a novel sulfate transporter: Positional cloning by fine-structure linkage disequilibrium mapping, Cell 78:1073–1087.

    Article  PubMed  Google Scholar 

  • Kahn, A. M., and Aronson P. S., 1983, Urate transport via anion exchange in dog renal microvillus membrane vesicles, Am. J. Physiol. 244:F56–F63.

    PubMed  CAS  Google Scholar 

  • Kanai, N., Lu, R., Satriano, J. A., Bao, Y., Wolkoff, A. W., and Schuster V. L., 1995, Identification and characterization of a prostaglandin transporter, Science 268:866–869.

    Article  PubMed  CAS  Google Scholar 

  • Keppler, D., König, J., Schaub, T., and Leier, I., 1998, Molecular basis of ATP-dependent transport of anionic conjugates in kidney and liver, Nova Acta Leopoldina NF 78:213–221.

    CAS  Google Scholar 

  • Kinne-Saffran, E., and Kinne, R. K. H., 1990, Isolation of lumenal and contralumenal plasma membrane vesicles from kidney, in: Methods in Enzymology, vol. 191, Biomembranes, Part V, Cellular and Subcellular Transport, Epithelial Cells (S. Fleischer and B. Fleischer, eds.), Academic Press, New York, pp. 450–469.

    Chapter  Google Scholar 

  • Koepsell, H., 1998, Organic cation transporters in intestine, kidney, liver, and brain, Annu. Rev. Physiol. 60: 243–266.

    Article  PubMed  CAS  Google Scholar 

  • Kühlbrandt, W., 1997, Pumping ions, Nature Struct. Biol. 4:773

    Article  PubMed  Google Scholar 

  • Lang, F., Waldegger, S., Murer, H., Foster, I., Koepsell, H., Palacin, M., Bröer, S., Capasso, G., Matskevich, J., Wagner, C., and Busch, A. E., 1998, Electrophysiology of proximal renal transporters, Nova Acta Leopoldina NF 78:73–78.

    CAS  Google Scholar 

  • Leal-Pinto, E., Tao, W., Rappaport J., Richardson, M., Knorr, B. A., and Abramson, R. G., 1997, Molecular cloning and functional reconstitution of a urate transporter/channel, J. Biol. Chem. 272: 617–625.

    Article  PubMed  CAS  Google Scholar 

  • Lopez-Nieto, C. E., You, G., Bush, K. T. Barros, E. J. G., Beier, D. R., and Nigam, S. K., 1997, Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney, J. Biol. Chem. 272:6471–6478.

    Article  PubMed  CAS  Google Scholar 

  • Markovich, D., Forgo, J., Stange, G., Biber, J., and Murer, H., 1993, Expression cloning of rat renal Na+/SO 2-4 -cotransport, Proc. Natl. Acad. Sci. USA 90:8073–8077.

    Article  PubMed  CAS  Google Scholar 

  • Markovich, D., Bissig, M., Sorribas, V., Hagenbuch, B., Meier, P. J., and Murer, H., 1994, Expression of rat renal sulfate transport systems in Xenopus laevis oocytes, J. Biol. Chem. 269:3022–3026.

    PubMed  CAS  Google Scholar 

  • Masuda, S., Saito, H., Nonoguchi, H., Tomita, K., and Inui, K., 1997, mRNA distribution and membrane localization of the OAT-K1 organic anion transporter in rat renal tubules, FEBS Lett. 407:127–131.

    Article  PubMed  CAS  Google Scholar 

  • Mori, K., Ogawa, Y., Ebihara, K., Aoki, T., Tamura, N., Sugawara, K., Kuwahara, T., Ozaki, S., Mukoyama, M., Tashiro, K., Tanaka, I., and Nakao, K., 1997, Kidney-specific expression of a novel mouse organic cation transporter-like protein, FEBS Lett. 417:37l–374.

    Article  Google Scholar 

  • Okuda, M., Saito, H., Urakami, Y., Takano, M., and Inui, K.-I., 1996, cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2, Biochem. Biophys. Res. Commun. 224:500–507.

    Article  PubMed  CAS  Google Scholar 

  • Ostermeier, C., Iwata, S., Ludwig, B., and Michel H., 1995, Fv fragment mediated crystallization of the membrane protein bacterial cytochrome c oxidase, Nature Struct. Biol. 2:842–846.

    Article  PubMed  CAS  Google Scholar 

  • Oude-Elferink, R. P. J., Paulusma, C., de Vree, M., Frijters C. M. G., and Groen, B. K., 1998, The role of ATP-transporters in hepatobiliary excretion, Nova Acta Leopoldina NF 78:157–163.

    CAS  Google Scholar 

  • Pajor, A. M., 1995, Sequence and functional characterization of renal sodium/dicarboxylate cotransporter, J. Biol. Chem. 270: 5779–5785.

    PubMed  CAS  Google Scholar 

  • Pietruck, F., and Ullrich, K. J., 1995, Transport interactions of different organic cations during their excretion by the intact rat kidney, Kidney Int. 47:1647–1657.

    Article  PubMed  CAS  Google Scholar 

  • Pritchard, J. B., 1988, Coupled transport of p-aminohippurate by rat kidney basolateral membrane vesicles, Am. J. Physiol. 255:F597–F604.

    PubMed  CAS  Google Scholar 

  • Roch-Ramel, F., Werner, D., and Guisan, B., 1994, Urate transport in brush-border membrane of human kidney, Am. J. Physiol. 266:F797–F805.

    PubMed  CAS  Google Scholar 

  • Roch-Ramel, F., Guisan, B., Jaeger, Ph., and Diezi, J., 1996, Transport of urate and other organic anions by anion exchange in human renal brush border membrane vesicles, Cell. Physiol. Biochem. 6:60–71.

    CAS  Google Scholar 

  • Roch-Ramel, F., Guisan, B., and Diezi, J., 1997, Effect of uricosuric and antiuricosuric agents on urate transport in human brush border membrane vesicles, J. Pharmacol. Exp. Ther. 280:839–845.

    PubMed  CAS  Google Scholar 

  • Saito, H., Masuda, S., and Inui, K., 1996, Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney, J. Biol. Chem. 271: 20719–20725.

    Article  PubMed  CAS  Google Scholar 

  • Schaub, T. P., Kartenbeck, J., König J., Vogel, O., Witzgall, R., Kriz, W., and Keppler, D., 1997, Expression of the conjugate export pump encoded by the mrp-2 gene in the apical membrane of kidney proximal tubules, J. Am. Soc. Nephrol. 8:1213–1221.

    PubMed  CAS  Google Scholar 

  • Sekine, T., Watanabe, N., Hosoyamada, M., Kanai, Y., and Endou, H., 1997, Expression cloning and characterization of a novel multispeciific organic anion transporter, J. Biol. Chem. 272: 18526–18529.

    Article  PubMed  CAS  Google Scholar 

  • Sekine, T., Watanabe, N., Hosoyamada, M., Kanai, Y., and Endou, H., 1998, A novel renal multispecific organic anion transporter (PAH transporter): Its structure and functional characteristics, Nova Acta Leopoldina, NF 78:119–126.

    CAS  Google Scholar 

  • Shimada, H., Moewes, B., and Burckhardt, G., 1987, Indirect coupling to Na+ of p-amino-hippuric acid uptake into rat renal basolateral membrane vesicles, Am. J. Physiol. 253:F795–F801.

    PubMed  CAS  Google Scholar 

  • Somogyi, A. A., Rumrich, G., Fritzsch, G., and Ullrich, K. J., 1996, Stereospecificity in contraluminal and luminal transporters of organic cations in the rat renal proximal tubules, J. Pharmacol. Exp. Ther. 278:31–36.

    PubMed  CAS  Google Scholar 

  • Steffgen, J., Burckhardt, B. C., Langenberg, C., Kühne, L., Müller, G. A., Burckhardt, G., and Wolff, N. A., 1999, Expression cloning and characterization of a novel sodium-dicar-boxylate cotransporter from winter flounder kidney. J. Biol. Chem. 274: 20191–20196.

    Article  PubMed  CAS  Google Scholar 

  • Sweet, H. D., Wolff, N. A., and Pritchard, J. B., 1997, Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney, J. Biol. Chem. 272: 30088–30095.

    Article  PubMed  CAS  Google Scholar 

  • Tamai, I., Yabuuchi, H., Nezu, J.-I., Sai, Y., Oku, A., Shimane, M., and Tsuji, A., 1997, Cloning and characterization of a novel pH dependent organic cation transporter, FEBS Lett. 419: 107–111.

    Article  PubMed  CAS  Google Scholar 

  • Ullrich, K. J., 1995, Interaction of diuretics with transport systems in the proximal renal tubule, in: Handbook of Experimental Pharmacology: Diuretics (R. Greger, H. Knauf, and E. Mutschler, eds.), Springer, Berlin, pp. 201–219.

    Google Scholar 

  • Ullrich, K. J., 1997, Renal transport of organic anions and organic cations. Structural re-quirements for substrates, J. Membr. Biol. 158:95–107.

    Article  PubMed  CAS  Google Scholar 

  • Ullrich, K. J., 1998, Features of substrates for interaction with renal transporters of organic anions and cations, Nova Acta Leopoldina NF 78:23–34.

    CAS  Google Scholar 

  • Ulrich, K. J., and Rumrich, G., 1988, Contraluminal transport systems in the proximal renal tubule involved in secretion of organic anion, Am. J. Physiol. 254:F453–F462.

    Google Scholar 

  • Ullrich, K. J., and Rumrich, G., 1990, Kidney: Microperfusion-double perfused tubule in situ, in: Methods in Enzymology, vol.191, Biomembranes, Part V, Cellular and Subcellular Transport, Epithelial Cells (S. Fleischer, and B. Fleischer, eds.), Academic Press, New York, pp. 98–107.

    Chapter  Google Scholar 

  • Ullrich, K. J., and Rumrich, G., 1992, Renal contraluminal transport systems for organic anions (para-aminohippurate, PAH) and organic cations (N 1-methyl-nicotinamide, NMeN) do not see the degree of substrate ionization, Pfluegers Arch, 421:286–288.

    Article  CAS  Google Scholar 

  • Ullrich, K. J., and Rumrich, G., 1995, Morphine analogues: Relationship between chemical structure and interaction with proximal tubular transporters: Contraluminal organic cation and anion transporter, luminal H+/organic cation exchanger, and luminal choline transporter, Cell. Physiol. Biochem. 5:290–298.

    Article  CAS  Google Scholar 

  • Ullrich, K. J., and Rumrich, G., 1996, Luminal transport system for choline+ in relation to other organic cation transport systems in the rat proximal tubule. Kinetics, specificity: Alkyl/arylamines, alkylamines with OH, O, SH, NH2, ROCO, RSCO and H2PO4-groups, methylaminostyryl, rhodamine, acridine, phenanthrene and cyanine compounds, Pfluegers Arch. 432:471–485.

    Article  CAS  Google Scholar 

  • Ullrich, K. J., and Rumrich, G., 1997, Luminal transport step of para-aminohippurate (PAH): Transport from PAH loaded proximal tubular cells into the tubular lumen of rat kidney in vivo, Pfluegers Arch. 433:735–743.

    Article  CAS  Google Scholar 

  • Ullrich, K. J., Fasold, H., Rumrich, G., and Klöss, S., 1984, Secretion and contraluminal uptake of dicarboxylic acids in the proximal convolution of the rat kidney, Pfluegers Arch. 400:241–249.

    Article  CAS  Google Scholar 

  • Ullrich, K. J., Rumrich, G., Klöss, S., and Lang, H.-J., 1985, Contraluminal sulfate transport in the proximal tubule of the rat kidney. V. Specificity: Phenolphthaleins, sulfonphthaleins, and other sulfo dyes, sulfamoyl-compounds and diphenylamine-2-car-boxylates, Pfluegers Arch. 404:311–318.

    Article  CAS  Google Scholar 

  • Ullrich, K. J., Rumrich, G., Fritzsch, G., and Klöss, S., 1987a, Contraluminal para-aminohippurate transport in the proximal tubule of the rat kidney. II. Specificity: Aliphatic dicarboxylic acid, Pfluegers Arch. 408:38–45.

    Article  CAS  Google Scholar 

  • Ullrich, K. J., Rumrich, G., and Klöss, S., 1987b, Contraluminal para-aminohippurate transport in the proximal tubule of the rat kidney. III. Specificity: Monocarboxylic acids, Pfluegers Arch. 409: 547–554.

    Article  CAS  Google Scholar 

  • Ullrich, K. J., Rumrich, G., and Klöss, S., 1989a, Contraluminal organic anion and cation transport in the proximal renal tubule: V. Interaction with sulfamoyl-and phenoxy diuretics, and □-lactam antibiotics, Kidney Int. 36:78–88.

    Article  PubMed  CAS  Google Scholar 

  • Ullrich, K. J., Rumrich, G., Wieland, T., and Dekant, W., 1989b, Contraluminal para-aminohippurate (PAH) transport in the proximal tubule of the rat kidney. VI: Amino acids, their N-methyl-, N-acetyl-and N-benzoylderivatives; glutathion-and cysteine conjugates, di-and oligopeptides, Pfluegers Arch. 415:342–350.

    Article  CAS  Google Scholar 

  • Ullrich, K. J., Rumrich, G., Gemborys M., and Dekant, W., 1990, Transformation and transport: How does metabolic transformation change the affinity of substrates for renal contraluminal anion and cation transporters? Toxicology Lett. 53:19–27.

    Article  CAS  Google Scholar 

  • Ullrich, K. J., Rumrich, G. Papavassiliou, F., Klöss, S., and Fritzsch, G., 1991a, Contraluminal para-aminohippurate transport in the proximal tubule of the rat kidney. VII. Specificity: Cyclic nucleotides, eicosanoids, Pfluegers Arch. 418:360–370.

    Article  CAS  Google Scholar 

  • Ullrich, K. J., Rumrich, G., Gemborys, M. W., and Dekant, W., 1991b, Renal transport and nephrotoxicity, in: Nephrotoxity (P. H. Bach, N. J. Gregg, M. F. Wilks, and L. Delacruz, eds.), Marcel Dekker, New York, pp. 1–8.

    Google Scholar 

  • Ullrich, K. J., Rumrich, G., Papavassiliou, F., Hierholzer, K., 1991c, Contraluminal p-aminohippurate transport in the proximal tubule of the rat kidney. VIII. Transport of corticosteroids, Pfluegers Arch. 418:371–382.

    Article  CAS  Google Scholar 

  • Ullrich, K. J., Rumrich, G., Neiteler, K., and Fritzsch, G., 1992, Contraluminal transport of organic cations in the proximal tubule of the rat kidney: II. Specificity: Anilines, phenylalkylamines (catecholamines), heterocyclic compounds (pyridines, quinolines, acridines), Pfluegers Arch. 420: 29–38.

    Article  CAS  Google Scholar 

  • Ullrich, K. J., Rumrich, G., David, C., and Fritzsch, G., 1993a, Interaction of xenobiotics with organic anion and cation transport systems in renal proximal tubule cells, in: Renal Disposition and Nephrotoxicity of Xenobiotics (M. W. Anders, W. Dekant, D. Henschler, H. Oberleithner, and S. Silbernagl, eds.), Academic Press, San Diego, California, pp. 97–115.

    Google Scholar 

  • Ullrich, K. J., Rumrich, G., David, C., and Fritzsch, G., 1993b, Bisubstrates: Substances that interact with renal contraluminal organic anion and organic cation transport systems: I. Amines, piperidines, piperazines, azepines, pyridines, quinolines, imidazoles, thiazoles, guanidines, and hydrazines, Pfluegers Arch. 425:280–299.

    Article  CAS  Google Scholar 

  • Ullrich, K. J., Rumrich, G., David, C., and Fritzsch, G., 1993c, Bisubstrates: substances that interact with both renal contraluminal organic anion and organic cation transport systems: II. Zwitterionic substrates: Dipeptides, cephalosporins, quinolon-carboxylate gyrase inhibitors, and phosphamide thiazine carboxylates. Nonionizable substates: Steroid hormones and cyclophosphamides, Pfluegers Arch. 425:300–312.

    Article  CAS  Google Scholar 

  • Ullrich, K. J., Fritzsch, G., Rumrich, G., and David, C., 1994, Polysubstrates that interact with renal contraluminal PAH, sulfate, and NMeN transport: Sulfamoyl-, sulfonylurea-, thiazide-, benzeneamino-carboxylate (nicotinate) compounds, J. Pharmacol. Exp. Ther. 269: 684–692.

    PubMed  CAS  Google Scholar 

  • Ullrich, K. J., Rumrich, G., Burke, R. T., Shirazi-Beechey, S. P., and Lang, H.-J., 1997, Interaction of alkyl/aryl-phosphonates, phosphonocarboxylates and diphosphonates with different anion transport systems in the proximal renal tubule, J. Pharmacol. Exp. Ther. 283: 1223–1229.

    PubMed  CAS  Google Scholar 

  • Weinman, E. J., Sansom, S. C., Bennett, S., and Kahn, A. M., 1983, Effect of anion exchange inhibitors and para-aminohippurate on the transport of urate in the rat proximal tubule, Kidney Int. 23: 832–837.

    Article  PubMed  CAS  Google Scholar 

  • Wolff, N. A., Werner, A., Burkhardt, S., and Burckhardt, G., 1997, Expression cloning and characterization of a renal organic anion transporter from Winter Flounder, FEBS Lett. 417: 287–291.

    Article  PubMed  CAS  Google Scholar 

  • Zhang, L., Dresser, M. J., Chun, J. K., Babbitt, P. C., and Giacomini, K. M., 1997a, Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A), J.Biol. Chem. 272: 16548–16554.

    Article  PubMed  CAS  Google Scholar 

  • Zhang, L., Dresser, M. J., Gray, A. T., Yost, S. C., Terashita, S., and Giacomini, K. M., 1997b, Cloning and functional expression of a human liver organic cation transporter, Mol. Pharmacol. 51:913–921.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Max Planck Institute for Biophysics, 60596, Frankfurt am Main, Germany

    Karl Julius Ullrich

Authors
  1. Karl Julius Ullrich
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Michigan, Ann Arbor, Michigan

    Gordon L. Amidon

  2. University of California, San Francisco, San Francisco, California

    Wolfgang Sadée

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Ullrich, K.J. (2002). Affinity of Drugs to the Different Renal Transporters for Organic Anions and Organic Cations. In: Amidon, G.L., Sadée, W. (eds) Membrane Transporters as Drug Targets. Pharmaceutical Biotechnology, vol 12. Springer, Boston, MA. https://doi.org/10.1007/0-306-46812-3_5

Download citation

  • DOI: https://doi.org/10.1007/0-306-46812-3_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46094-4

  • Online ISBN: 978-0-306-46812-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation