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Molecular and Functional Characteristics of Cloned Human Organic Cation Transporters

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Membrane Transporters as Drug Targets

Part of the book series: Pharmaceutical Biotechnology ((PBIO,volume 12))

Conclusions

Within the last 5 years the organic cation transport field has moved from tissue and cellular levels to a molecular level of investigation. As we gain a better understanding of the genes and proteins responsible for the multiple mechanisms of organic cation transport, we can begin to apply this knowledge to pharmaceutical and drug discovery research. For example, in the future, we will know all of the transporters that are expressed in each tissue and have a substrate/inhibitor profile for each transporter. With this information, we could begin to predict, for example, organ-specific clearances or organ-specific distributions of drugs. Perhaps we will discover a brain-specific organic cation transporter which could serve as a drug target. It will be years and perhaps several more decades before all of these transporters are cloned and characterized. We have made a good start and there will be years of exciting work and discovery in the organic cation transport field in the future.

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Author information

Authors and Affiliations

  1. Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, California, 94143

    Mark J. Dresser, Lei Zhang & Kathleen M. Giacomini

Authors
  1. Mark J. Dresser
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  2. Lei Zhang
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  3. Kathleen M. Giacomini
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Editor information

Editors and Affiliations

  1. University of Michigan, Ann Arbor, Michigan

    Gordon L. Amidon

  2. University of California, San Francisco, San Francisco, California

    Wolfgang Sadée

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© 2002 Kluwer Academic Publishers

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Dresser, M.J., Zhang, L., Giacomini, K.M. (2002). Molecular and Functional Characteristics of Cloned Human Organic Cation Transporters. In: Amidon, G.L., Sadée, W. (eds) Membrane Transporters as Drug Targets. Pharmaceutical Biotechnology, vol 12. Springer, Boston, MA. https://doi.org/10.1007/0-306-46812-3_15

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  • DOI: https://doi.org/10.1007/0-306-46812-3_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46094-4

  • Online ISBN: 978-0-306-46812-4

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