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Production and Effects of Reactive Oxygen Species by Spermatozoa

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Reactive Oxygen Species in Biological Systems

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References

  • Aitken, R. J., and Clarkson, J. S., 1987, Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa, J. Reprod. Fertil. 81:459–469.

    CAS  PubMed  Google Scholar 

  • Aitken, R. J., and Clarkson, J. S., 1988, Significance of reactive oxygen species and antioxidants in defining the efficacy of sperm preparation techniques, J. Androl. 9:367–376.

    CAS  PubMed  Google Scholar 

  • Aitken, R. J., and West, K. M., 1990, Analysis of the relationship between reactive oxygen species production and leucocyte infiltration in fractions of human semen separated on Percoll gradients, Int. J. Androl. 13:433–451.

    CAS  PubMed  Google Scholar 

  • Aitken, R. J., Clarkson, J. S., and Fishel, S., 1989a, Generation of reactive oxygen species, lipid peroxidation and human sperm function. Biol. Reprod. 40:183–197.

    Google Scholar 

  • Aitken, R. J., Clarkson, J. S., Hargreave, T. B., Irvine, D. S., and Wu, F. C, 1989b, Analysis of relationship between defective sperm function and the generation of reactive oxygen species in cases of oligozoospermia, J. Androl. 10:214–220.

    CAS  PubMed  Google Scholar 

  • Aitken, R. J., Irvine, D. S., and Wu, F. C., 1991, Prospective analysis of sperm-oocyte fusion and reactive oxygen species generation as criteria for the diagnosis of infertility, Am. J. Obstet. Gynecol. 164:542–551.

    CAS  PubMed  Google Scholar 

  • Aitken, R. J., Buckingham, D., West, K., Wu, F. C., Zikopoulos, K., and Richardson, D. W., 1992, On the contribution of leucocytes and spermatozoa to the high levels of reactive oxygen species recorded in the ejaculates of oligozoospermic patients, J. Reprod. Fertil. 94:451–462.

    CAS  PubMed  Google Scholar 

  • Aitken, R. J., Harkiss, D., and Buckingham, D., 1993a, Relationship between iron-catalysed lipid peroxidation potential and human sperm function, J. Reprod. Fertil. 98:257–265.

    CAS  PubMed  Google Scholar 

  • Aitken, R. J., Harkiss, D., and Buckingham, D. W., 1993b, Analysis of lipid peroxidation mechanisms in human spermatozoa, Mol. Reprod. Dev. 35:302–315.

    Article  CAS  PubMed  Google Scholar 

  • Aitken, R. J., West, K., and Buckingham, D., 1994a, Leukocyte infiltration into the human ejaculate and its association with semen quality, oxidalive stress and sperm function, J. Androl. 15:343–352.

    CAS  PubMed  Google Scholar 

  • Aitken, R. J., Krausz, C., and Buckingham, D. W., 1994b, Relationship between the biochemical marker for human sperm quality, creatine kinase, and the mechanisms responsible for the generation of reactive oxygen species, Mol. Reprod. Dev. 39:268–279.

    Article  CAS  PubMed  Google Scholar 

  • Aitken, R. J., Paterson, M., Fisher. H., Buckingham, D. W., and van Duin, M., 1995, Redox regulation of tyrosine phosphorylation in human spermatozoa and its role in the control of human sperm function, J. Cell Sci. 108:2017–2025.

    CAS  PubMed  Google Scholar 

  • Aitken, R. J., Buckingham, D. W., Harkiss, D., Paterson, M., Fisher, H., and Irvine, D. S., 1996a, The extragenomic action of progesterone on human spermatozoa is influenced by redox regulated changes in tyrosine phosphorylation during capacitation, Mol. Cell. Endocrinol. 117:83–93.

    Article  CAS  PubMed  Google Scholar 

  • Aitken, R. J., Buckingham, D. W., West, K., and Brindle, J., 1996b, On the use of paramagnetic beads and ferrofluids to assess and eliminate the leukocytic contribution to oxygen radical generation by human sperm suspensions, Am. J. Reprod. Immunol. 35:541–551.

    CAS  PubMed  Google Scholar 

  • Aitken, R. J., Buckingham, D. W., Carreras, A., and Irvine, D. S., 1996c, Superoxide dismutase in human sperm suspensions: Relationships with cellular composition, oxidative stress and sperm function, Free Radical Biol. Med. 21:495–504.

    Article  CAS  Google Scholar 

  • Alvarez, J. G., and Storey, B. T., 1982, Spontaneous lipid peroxidation in rabbit epididymal spermatozoa: Its effect on sperm motility, Biol. Reprod. 27:1102–1108.

    Article  CAS  PubMed  Google Scholar 

  • Alvarez, J. G., and Storey, B. T., 1984, Lipid peroxidation and the reactions of superoxide and hydrogen peroxide in mouse spermatozoa, Biol. Reprod. 30:833–841.

    CAS  PubMed  Google Scholar 

  • Alvarez, J. G., and Storey, B. T., 1989, Role of glutathione peroxidase in protecting mammalian spermatozoa from loss of motility caused by spontaneous lipid peroxidation, Gamete Res. 23:77–90.

    Article  CAS  PubMed  Google Scholar 

  • Alvarez, J. G., Touchstone, J. C., Blasco, L., and Storey, B. T., 1987, Spontaneous lipid peroxidation and production of hydrogen peroxide and superoxide in human spermatozoa, J. Androl. 8:338–348.

    CAS  PubMed  Google Scholar 

  • Bearpark, T., Salvemini, D., Sneddon, J. M., and Vane, J. R., 1988, Endothelium-derived relaxing factor (EDRF) and superoxide anions modulate platelet adhesion to endothelial cells, J.Physiol (London) 339:12P.

    Google Scholar 

  • Bize, I., Santander, G., Cabello, P., Driscoll, D., and Sharpe, C., 1991, Hydrogen peroxide is involved in hamster sperm capacilation in vitro, Biol. Reprod. 44:398–403.

    Article  CAS  PubMed  Google Scholar 

  • Casano, R., Orlando, C., Serio, M., and Forti, G., 1991, LDH and LDH-X activity in sperm from normospermic and oligozoospermic men, Int. J. Androl. 14:257–263.

    CAS  PubMed  Google Scholar 

  • de Lamirande, E., and Gagnon, C., 1993a, Human sperm hyperactivation in whole semen and its association with low superoxide scavenging capacity in seminal plasma, Fertil. Steril. 59:1291–1295.

    PubMed  Google Scholar 

  • de Lamirande, E., and Gagnon, G., 1993b, A positive role for the superoxide anion in triggering hyperactivation and capacitalion of human spermatozoa, Int. J. Androl. 16:21–25.

    PubMed  Google Scholar 

  • de Lamirande, E., and Gagnon, G., 1993c, Human sperm hyperactivation and capacitation as part of an oxidative process, Free Radical Biol. Med. 14:157–166.

    Google Scholar 

  • Fraga, C. G., Motchnik, P. A., Shigenaga, M. K., Helbock, H. J., Jacob, R. A., and Ames, B. N., 1991, Ascorbic acid protects against endogenous oxidative DNA damage in human sperm, Proc. Natl. Acad. Sci. USA 88:11003–11006.

    CAS  PubMed  Google Scholar 

  • Gomez, E., Buckingham, D. W., Brindle, J., Lanzafame, F., Irvine, D. S., and Aitken, R. J., 1996, Development of an image analysis system to monitor the retention of residual cytoplasm by human spermatozoa: Correlation with biochemical markers of the cytoplasmic space, oxidative stress, and sperm function, J. Androl. 17:276–287.

    CAS  PubMed  Google Scholar 

  • Griveau, J. F., Renard, P., and Le Lannou, D., 1994, An in vitro promoting role for hydrogen peroxide in human sperm capacitation. Int. J. Androl. 17:300–307.

    CAS  PubMed  Google Scholar 

  • Griveau, J. F., Renard, P., and Le Lannou, D., 1995, Superoxide anion production by human spermatozoa as a part of the ionophore-induced acrosome reaction process, Int. J. Androl. 18:67–74.

    CAS  PubMed  Google Scholar 

  • Holland, M. K., Alvarez, J. G., and Storey, B. T., 1982, Production of superoxide and activity of superoxide dismutase in rabbit epididymal spermatozoa, Biol. Reprod. 27:1109–1118.

    Article  CAS  PubMed  Google Scholar 

  • Huszar, G., Corrales, M., and Vigue, L., 1988a, Correlation between sperm creatine phosphokinase activity and sperm concentrations in normospermic and oligozoospermic men, Gamete Res. 19:67–75.

    Article  CAS  PubMed  Google Scholar 

  • Huszur, G., Vigue, L., and Corrales, M., 1988b, Sperm creatine phosphokinase quality in normospermic, variablespermic and oligospermic men, Biol. Reprod. 38:1061–1066.

    Google Scholar 

  • Iwasaki, A., and Gagnon, C., 1992, Formation of reactive oxygen species in spermatozoa of infertile patients, Fertil. Steril. 57:409–416.

    CAS  PubMed  Google Scholar 

  • Jones, R., and Mann, T., 1973, Lipid peroxidation in spermatozoa, Proc. R. Soc. London B Ser. 184:103–107.

    CAS  Google Scholar 

  • Jones, R., and Mann, T., 1976, Lipid peroxides in spermatozoa: Formation, role of plasmalogen, and physiological significance, Proc. R. Soc. London B Ser. 193:317–333.

    CAS  Google Scholar 

  • Jones, R., and Mann, T., 1977a, Toxicity of exogenous fatty acid peroxides towards spermatozoa, J. Reprod. Fertil. 50:255–260.

    CAS  PubMed  Google Scholar 

  • Jones, R., and Mann, T., 1977b, Damage to ram spermatozoa by peroxidation of endogenous fatty acids, J. Reprod. Fertil. 50:261–268.

    CAS  PubMed  Google Scholar 

  • Jones, R., Mann, T., and Sherins, R. J., 1978, Adverse effects of peroxidized lipid on human spermatozoa, Proc. R. Soc. London B Ser. 201:413–417.

    CAS  Google Scholar 

  • Jones, R., Mann, T., and Sherins, R. J., 1979, Peroxidative breakdown of phospholipids in human spermatozoa: Spermicidal effects of fatty acid peroxides and protective action of seminal plasma, Fertil. Steril. 31:531–537.

    CAS  PubMed  Google Scholar 

  • Kobayashi, T., Miyazaki, T., Natori, M., and Nozawa, S., 1991, Protective role of superoxide dismutase in human sperm motility Superoxide dismutase activity and lipid peroxide in human seminal plasma and spermatozoa, Hum. Reprod. 6:987–991.

    CAS  PubMed  Google Scholar 

  • Kumar, G. P., Laloraya, M., and Laloraya, M. M., 1991, Superoxide radical level and superoxide dismutase activity changes in maturing mammalian spermatozoa, Andrologia 23:171–175.

    CAS  PubMed  Google Scholar 

  • Lafuze, J. E., Weisman, S. J., Ingraham, L. M., Butterick, C. J., Alpert, L. A., and Baehner, R. L., 1983, The effect of vitamin E on rabbit neutrophil activation, in Biology of Vitamin E, Ciba Foundation Symposium 101 (R. Porter and J. Whelan, eds.), pp. 130–140, Pitman Press, Bath.

    Google Scholar 

  • Lenzi, A., Culasso, F., Gardini, L., Lombado, F., and Dondero, F., 1993, Placebo-controlleddouble-blind cross-over trial of glutathione therapy in male infertility, Hum. Reprod. 8:1657–1662.

    CAS  PubMed  Google Scholar 

  • MacLeod, J., 1943, The role of oxygen in the metabolism and motility of human spermatozoa, Am. J. Physiol. 138:512–518.

    CAS  Google Scholar 

  • Mazzilli, F., Rossi, T., Marchesini, M., Ronconi, C., and Dondero, F., 1994, Superoxide anion in human semen related to seminal parameters and clinical aspects, Fertil. Steril. 62:862–868.

    CAS  PubMed  Google Scholar 

  • Meier, B., Cross, A. R., Hancock, J. T., Kaup, F. J., and Jones, O. T. G., 1991, Identification of a superoxidegeneraling NADPH oxidase system in human fibroblasts, Biochem. J. 275:241–245.

    CAS  PubMed  Google Scholar 

  • Mennella, M.R.F., and Jones, R., 1980, Properties of spermatozoal superoxide dismutase and lack of involvement of superoxides in metal-ion-catalysed lipid-peroxidation reactions in semen, Biochem. J. 191:289–297.

    CAS  PubMed  Google Scholar 

  • Moilanen, J., Howatta, O., and Lindroth, L., 1993, Vitamin E levels in seminal plasma can be elevated by oral administration of vitamin E in infertile men, Int. J. Androl. 16:165–166.

    CAS  PubMed  Google Scholar 

  • Perry, A. C. F., Jones, R., Niang, L. S. P., Jackson, R. M., and Hall, L., 1992, Genetic evidence for an androgen-regulated epididymal secretory glutathione peroxidase whose transcript does not contain a selenocysteine codon, Biochem. J. 285:863–870.

    CAS  PubMed  Google Scholar 

  • Perry, A. C. F., Jones, R., and Hall, L., 1993, Isolation and characterization of a rat cDNA clone encoding a secreted superoxide dismutase reveals the epididymis to be a major site of its expression, Biochem. J. 293:21–25.

    CAS  PubMed  Google Scholar 

  • Radeke, H. H., Cross, A. R., Hancock, J. T., Jones, O. T. G., Nakamura, M., Kaever, V., and Resch, K. 1991, Functional expression of NADPH oxidase components (α and β-subunits of cytochrome b558 and 45-kDa flavoprotein) by intrinsic human glomerular mesangial cells, J. Biol. Chem. 266:21025–21029.

    CAS  PubMed  Google Scholar 

  • Rao, B., Soufir, J. C., Martin, M., and David, G., 1989, Lipid peroxidation in human spermatozoa as related to midpiece abnormalities and motility. Gamete Res. 24:127–134.

    Article  CAS  PubMed  Google Scholar 

  • Sanocka, D., Miesel, R., Jedrzejczak, P., and Kurpisz, M. K., 1996, Oxidative stress and male infertility, J. Androl. 17:449–454.

    CAS  PubMed  Google Scholar 

  • Sato, I., 1995, Characterization of the 84-kDa protein with ABH activity in human seminal plasma, Jpn. J. Legal Med. 49:281–293.

    CAS  Google Scholar 

  • Sevanian, A., Wratten, M. L., McLeod, L. L., and Kim, E., 1988, Lipid peroxidation and phopholipase A2 activity in liposomes composed of unsaturated phospholipids: A structural basis for enzyme activation, Biochim. Biophys. Acta 961:316–327.

    CAS  PubMed  Google Scholar 

  • Smith, R., Vantman, D., Ponce, J., Escobar, J., and Lissi, E., 1996, Total antioxidant capacity of human seminal plasma, Hum. Reprod. 11:1655–1660.

    CAS  PubMed  Google Scholar 

  • Thiele, J. J., Freisleben, H. J., Fuchs, J., and Ochensendorf, F. R., 1995, Ascorbic acid and urate in human seminal plasma: Determination and interrelationship with chemiluminescence in washed semen, Hum. Reprod. 10:110–115.

    CAS  PubMed  Google Scholar 

  • Tosic, J., and Walton, A., 1946, Formation of hydrogen peroxide by spermatozoa and its inhibitory effect on respiration, Nature 158:485.

    CAS  Google Scholar 

  • Tosic, J., and Walton, A., 1950, Metabolism of spermatozoa. Formation of hydrogen peroxide by spermatozoa and its effects on motility and survival, Biochem. J. 47:199–212.

    CAS  Google Scholar 

  • Weese, D. L., Peaster, M. L., Himsl, K. K., Leach, G. E., Lad, P. M., and Zimmern, P. E., 1993, Stimulated reactive oxygen species generation in the spermatozoa of infertile men, J. Urol. 149:64–67.

    CAS  PubMed  Google Scholar 

  • Zini, A., de Lamirande, E., and Gagnon, C., 1993, Reactive oxygen species in semen of infertile patients: Levels of superoxide dismutase-and catalase-like activities in seminal plasma and spermatozoa, Int. J. Androl. 16:183–188.

    CAS  PubMed  Google Scholar 

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  1. MRC Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh, EH3 9EW, Scotland

    R. John Aitken

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© 2002 Kluwer Academic Publishers

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Aitken, R.J. (2002). Production and Effects of Reactive Oxygen Species by Spermatozoa. In: Reactive Oxygen Species in Biological Systems. Springer, Boston, MA. https://doi.org/10.1007/0-306-46806-9_20

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  • DOI: https://doi.org/10.1007/0-306-46806-9_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-45756-2

  • Online ISBN: 978-0-306-46806-3

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