Skip to main content
SpringerLink
Log in

Melatonin Antioxidative Protection by Electron Donation

  • Chapter
Reactive Oxygen Species in Biological Systems

  • 401 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abe, M., Reiter, R. J., Orrhii, P. H., Hara, M., Poeggeler, B., and Barlow-Walden, L. R., 1994, Inhibitory effect of melatonin on cataract formation in newborn rats: Evidence of an antioxidative role for melatonin, J. Pineal Res. 17:94–100.

    CAS  PubMed  Google Scholar 

  • Agarwal, S., and Sohal, R. S., 1994, DNA oxidative damage and life expectancy in houseflies, Proc. Natl. Acad. Sci. USA 91:12332–12335.

    CAS  PubMed  Google Scholar 

  • Antolin, I., Rodriguez, C., Sainz, R. M., Mayo, J. C., Uria, H., Kotler, M. I., RodriguezColunga, M. J., Tolivia, D., and Menendez-Pelaez, A., 1996, Melatonin prevents cell damage: Effect on gene expression for antioxidant enzymes, Fed. Am. Soc. Exp. Biol. 10:882–890.

    CAS  PubMed  Google Scholar 

  • Balzer, I., and Hardeland, R., 1991, Photoperiodism and effects of indoleamines in a unicellular alga, Gonyaulax polyedra. Science 253:795–797.

    CAS  Google Scholar 

  • Balzer, I., and Hardeland, R., 1996, Melatonin in algae and higher plants—Possible role as phytohormone and antioxidant, Bot. Acta 109:180–183.

    CAS  Google Scholar 

  • Barlow-Walden, L. R., Reiter, R. J., Abe, M., Pablos, M. I., Menendez-Pelaez, A., Chen, L.-D., and Poeggeler, B., 1995, Melatonin stimulates brain glutathione peroxidase activity, Neurochem. Int. 26:497–502.

    CAS  PubMed  Google Scholar 

  • Becker-Andre, M., Wiesenthal, I., Schaeren-Wiemers, N., Andre, E., Missbach, M., Saurat, J. H., and Carlberg, C., 1994, Pineal hormone melatonin binds and activates an orphan of the nuclear receptor superfamily, J. Biol. Chem. 269:28531–28534.

    CAS  PubMed  Google Scholar 

  • Bender, D. A., 1975, Methionine, in Amino Acid Metabolism (D. A. Bender, ed.), pp. 126–132, Wiley, New York.

    Google Scholar 

  • Blinkenstaff, R. T., Brandstadter, S. M., Reddy, S., and Witt, R., 1994, Potential radioprotective agents: 1. Homologs of melatonin, J. Pharm. Sci. 83:216–218.

    Google Scholar 

  • Cagnoli, C. M., Atabay, C., Kharlamov, E., and Manev, H., 1996, Melatonin protects neurons from singlet-oxygen-induced apoptosis, J. Pineal Res. 18:222–226.

    Google Scholar 

  • Chan, T. Y., and Tang, P. L., 1996, Characterization of the antioxidant effects of melatonin and related indoleamines in vitro, J. Pineal Res. 20:187–191.

    CAS  PubMed  Google Scholar 

  • Dubocovich, M. L., 1995, Melatonin receptors: Are there multiple subtypes? Trends Pharmaco. 16:50–56.

    CAS  Google Scholar 

  • Felix, K., Pairet, M., and Zimmermann, R., 1996, The antioxidative activity of the mucoregulatory agents: Ambroxol, bromhexineand N-acetyl-l-cysteine. A pulse radiolysis study, Life Sci. 59:1141–1147.

    Article  CAS  PubMed  Google Scholar 

  • Flaugh, M. E., Crowell, T. A., Clemens, J. A., and Sawyer, B. D., 1979, Synthesis and evaluation of antiovulatory activity of a variety of melalonin analogues, J. Med. Chem. 22:63–68.

    Article  CAS  PubMed  Google Scholar 

  • Floyd, R. A., 1993, Basic free radical chemistry, in Free Radicals in Aging (B. P. Yu, ed.), pp. 39–55, CRC Press, Boca Raton.

    Google Scholar 

  • Gilad, E., Cuzzocrea, S., Zingarelli, B., Salzman, A. L., and Szabo, D., 1997, Melatonin is a scavenger of peroxymtrite, Life Sci. 60:PL169–PL174.

    Article  CAS  PubMed  Google Scholar 

  • Gilbert, D., 1994, Keeping reactive oxygen species (ROS) in their proper place, Ann. N. Y. Acad. Sci. 738:1–7.

    CAS  PubMed  Google Scholar 

  • Giusti, P., Guisella, M., Lipartiti, M., Milani, D., Zhu, W., Vicini, S., and Manev, H., 1995, Melatonin protects primary cultures of cerebellar granule neurons from kainate but not from N-methyl-D-aspartate excitotoxicity, Exp. Neurol. 131:39–46.

    Article  CAS  PubMed  Google Scholar 

  • Giusti, P., Francheschini, D., Petrone, M., Manev, H., and Floreanin, M., 1996, In vitro and in vivo protection against kainate-induced excitotoxicity by melatonin, J. Pineal Res. 20:226–231.

    CAS  PubMed  Google Scholar 

  • Golstein, P., 1997, Controlling cell death, Science 275:1081–1082.

    Article  CAS  PubMed  Google Scholar 

  • Haendeler, J., Zeiher, A. M., and Dimmeler, S., 1996, Vitamin C and E prevent lipopolysaccharide-induced apoptosis in human endothelial cells by modulation of bcl-2 and bax, Eur. J. Pharmacol. 317:407–411.

    Article  CAS  PubMed  Google Scholar 

  • Halliwell, B., 1995, Antioxidant characterization: Methodology and mechanism, Biochem. Pharmacol. 49:1341–1348.

    Article  CAS  PubMed  Google Scholar 

  • Hamada, N., and Nagase, M., 1996, In vivo effect of OPC15161, a superoxide scavenger, on anti-Thy 1 nephritis, Eur. J. Pharmacol. 317:123–128.

    Article  CAS  PubMed  Google Scholar 

  • Hardeland, R., Reiter, R. J., Poeggeler, B., and Tan, D.-X., 1993, The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances, Neurosci. Biobehav. Rev. 17:347–357.

    Article  CAS  PubMed  Google Scholar 

  • Harman, D., 1956, Aging: A theory based on free radical and radiation chemistry, J. Gerontol. 11:298–300.

    CAS  PubMed  Google Scholar 

  • Harman, D., 1983, Free radical theory of aging: Consequences of mitochondrial aging, Age 6:86–94.

    CAS  Google Scholar 

  • Hirata, F., Hayaishi, O., Tokuyama, T., and Senoh, S., 1974, In vitro and in vivo formation of two new metabolites of melatonin, J. Biol. Chem. 249:1311–1315.

    CAS  PubMed  Google Scholar 

  • Itoh, T., Kamisaki, K., Kitamura, Y., Omodani, H., and Hamada, T., 1992, Cystathionine, a physiological prodrug of cysteine, protects against acetaminophen-induced liver toxicity, in Frontiers and New Horizons in Amino Acid Research (K. Takai, ed.), pp. 451–455, Elsevier, Amsterdam.

    Google Scholar 

  • Kane, D. J., Sarafian, T. A., Anton, R., Hahn, H., Gralla, E. B., Valentine, J. S., Ord, T., and Bredesen, D. E., 1993, Bcl-2 inhibition of neuronal death: Decreased generation of reactive oxygen species, Science 262:1274–1277.

    CAS  PubMed  Google Scholar 

  • Kitamura, Y, Kamisaki, Y, and Itoh, T., 1989, Hepatoprotective effects of cystathionine against acetaminophen-induced necrosis, J. Pharmacol. Exp. Ther. 250:667–671.

    CAS  PubMed  Google Scholar 

  • Kodama, H., Ikeda, H., Awat, S., and Nakayama, K., 1985, Cystathionine accumulation in various regions of brain after DL-propargylglycine-treated rats, J. Neurochem. 44:1207–1209.

    CAS  PubMed  Google Scholar 

  • Kodama, H., Sakaki, K., Mizobuchi, N., and Kikuchi, R., 1988, Contents of cystathionine and taurine in various cerebellar regions of DL-propargylglycine-treated rats, J. Neurochem. 51:1046–1048.

    CAS  PubMed  Google Scholar 

  • Kopin, I. J., Pare, C. M. B., Axelrod, J., and Weissbach, H., 1961, The fate of melatonin in animals, J. Biol. Chem. 236:3072–3076.

    CAS  PubMed  Google Scholar 

  • Kothari, L. S., and Subramanian, S., 1992, A possible modulatory influence of melatonin on representative phase I and phase II drug metabolizing enzymes in 9,10-dimethyl-1,2-benzanthracene induced rat mammary tumorigenesis, Anti-Cancer Drugs 3:623–628.

    CAS  PubMed  Google Scholar 

  • Longoni, B., Salgo, M. G., Pryor, W. A., and Marchiafara, P. L., 1995, Melatonin inhibits oxygen radicals induced lipid peroxidation, Soc. Neurosci. Abstr. 21:Abstract 196.15.

    Google Scholar 

  • Machida, Y, Zhang, J. Y, Hashimoto, K., Wakiguchi, H., Kurashige, T., Masuoka, N., Ubuka, T., and Kodama, H., 1995, Identification of perhydro-l,4-thiazepine-3,5-dicarboxylic acid, cystathionine mono-ore acids, cystathionine ketimines, cystathionine sulfoxide and N-acetylcystathionine sulfoxide in the urine sample of D,L-propargylglycine-treated rats, Physiol. Chem. Phys. Med. NMR 27:203–216.

    CAS  PubMed  Google Scholar 

  • Manchester, L. C., Poeggeler, B., Alvares, F. L., Odgen, G. B., and Reiter, R. J., 1995, Melatonin immunore-activity in the photosynthetic prokaryote, Rhodospirillum rubrum: Implications for an ancient antioxidant system, Cell. Mol. Biol. Res. 41(5):391–395.

    CAS  PubMed  Google Scholar 

  • Marshall, K.-A., Reiter, R. J., Poeggeler, B., Aruma, O. I., and Halliwell, B., 1996, Evaluation of the antioxidative activity of melatonin in vitro, Free Radical Biol. Med. 21:307–315.

    Article  CAS  Google Scholar 

  • Meister, A.,1992, On the antioxidant effect of ascorbic acid and glutathione, Biochem. Pharmacol. 44:1905–1915.

    Google Scholar 

  • Melchiorri, M., Reiter, R. J., Attia, A. M., Hara, M., Burgess, A., and Nistico, G., 1994, Potent protective effect of melatonin on in vivo paraquat-induced oxidative damage, Life Sci. 56:83–89.

    Article  Google Scholar 

  • Menendez-Peleaz, A., Poeggeler, B., Reiter, R. J., Barlow-Walden, L. R., Pablos, M. I., and Tan, D.-X., 1993, Nuclear localization of melatonin in different tissues: Immunocytochemical and radioimmunoassay evidence, J. Cell. Biochem. 53:373–382.

    Google Scholar 

  • Miller, J. W., Selhub, J., and Joseph, J. A., 1996, Oxidative damage caused by free radicals during catecholeamine autooxidation: Protective effects of O-methylation and melatonin, Free Radical Biol. Med. 21:241–249.

    CAS  Google Scholar 

  • Miquel, J., and Economos, A. C., 1979, Favorable effects of the antioxidant sodium and magnesium thiazolidine carboxylate on the vitality and life span of Drosophila and mice, Exp. Gerontol. 14:279–285.

    Article  CAS  PubMed  Google Scholar 

  • Nakano, Y, Kawaguchi, T., Sumitomo, J., Takizawa, T., Uetsuki, S., Sugawara, M., and Kido, M., 1991, Novel inhibitor of superoxide anion generation OPC-15160 and OPC-15161, taxonomy, fermentation, isolation, physicochemical properties, biological characteristics and structure determination, J. Antibiol. 44:52–64.

    CAS  Google Scholar 

  • Nath, K. A., and Salahudeen, A. K., 1993, Autooxidation of cysteine generates hydrogen peroxide: Cytotoxicity and attenuation of pyruvate, Am. J. Physiol. 264:F306–F314.

    CAS  PubMed  Google Scholar 

  • Oakin-Bendahan, S., Anis, Y, Nir, I., and Zisapel, N., 1995, Effects of long-term administration of melatonin and a putative antagonist on the ageing rat, Neuro Report 6:785–788.

    Google Scholar 

  • Oeiru, S., and Vochitu, E., 1965, The effect of the administration of compounds containing sulfhydryl groups on the survival rates of mice, rats and guinea pigs, J. Gerontol. 20:417–419.

    Google Scholar 

  • Ohlenschläger, G., 1991, Reaktionen des G-SH als Scavenger (Radikalfänger) oder mit Scavengern, in Das Glutathionsystem (G. Ohlenschläger, ed.), pp. 78–96, Verlag fur Medizin Dr. Ewald Fischer, Heidelberg.

    Google Scholar 

  • Pieri, C., Marra, M., Moroni, F., Recchioni, R., and Marcheselli, F., 1994, Melatonin: A peroxyl radical scavenger more effective than vitamin E, Life Sci. 15:PL271–PL276.

    Google Scholar 

  • Pieri, C., Moroni, F., Marra, M., Marcheselli, F., and Recchioni, R., 1995, Melatonin is an efficient antioxidant, Arch. Gerontol. Geriatr. 20:159–165.

    Article  CAS  PubMed  Google Scholar 

  • Pierpaoli, W., and Regelson, W., 1994, Pineal control of aging: Effect of melatonin and pineal grafting on aging mice, Proc. Natl. Acad. Sci. USA 91:781–791.

    Google Scholar 

  • Pierrefieche, G., Topall, G., Courboin, G., Henriet, I., and Laborit, H., 1993, Antioxidant activity of melatonin in mice, Res. Commun. Chem. Pathol. Pharmacol. 80:211–223.

    Google Scholar 

  • Poeggeler, B., 1993, Melatonin and the light-dark zeitgeber in vertebrates, invertebrates and unicellular organisms. Introduction to the multi-author review on melatonin, Experientia 49:611–613.

    Article  CAS  PubMed  Google Scholar 

  • Poeggeler, B., and Hardeland, R., 1994, Detection and quantification of melatonin in a dinoflagellate, Gonyaulax polyedra: Solutions to the problem of methoxyindole destruction in non-vertebrate material, J. Pineal Res. 17:1–10.

    CAS  PubMed  Google Scholar 

  • Poeggeler, B., Balzer, I., Hardeland, R., and Lerchl, A., 1991, Pineal hormone melatonin oscillates also in the dinoflagellate Gonyaulax polyedra, Nulurwissenschaften 78:268–269.

    CAS  Google Scholar 

  • Poeggeler, B., Reiter, R. J., Tan, D.-X., Chen, L.-D., and Manchester, L. C., 1993, Melatonin, hydroxyl radical-mediated oxidative damage, and aging, J. Pineal Res. 14:151–168.

    CAS  PubMed  Google Scholar 

  • Poeggeler, B., Saarela, S., Reiter, R. J., Tan, D.-X., Chen, L.-D., and Manchester, L. C., 1994, Melatonin-A highly potent endogenous radical scavenger and electron donor: New aspects of the oxidation chemistry of this indole assessed in vitro, Ann. N.Y. Acad. Sci. 738:419–420.

    CAS  PubMed  Google Scholar 

  • Poeggeler, B., Reiter, R., Hardeland, R., Sewerynek, E., Melchiorri, D., and Barlow-Walden, L. R., 1995, Melatonin, a mediator of electron transfer and repair reactions, acts synergistically with the chain breaking antioxidants ascorbate, Trolox and glutathione, Neuroendocrinol. Lett. 195:87–92.

    Google Scholar 

  • Poeggeler, B., Reiter, R. J., Hardeland, R., Tan, D.-X., and Barlow-Walden, L. R., 1996, Melatonin and structurally related, endogenous indoles act as potent electron donors and radical scavengers in vitro, Redox Rep. 2:179–184.

    CAS  Google Scholar 

  • Pozo, D., Reiter, R. J., Calvo, J. P., and Guerrero, J. M., 1994, Physiological concentrations of melatonin inhibit nitric oxide synthetase in rat cerebellum, Life Sci. 55:P 55–P 60.

    Article  Google Scholar 

  • Puka-Sundvall, M., Eriksson, P., Nilsson, M., Sandberg, M., and Lehmann, A., 1995, Neurotoxicity of cysteine: Interaction with glutamate, Brain Res. 705:65–70.

    CAS  PubMed  Google Scholar 

  • Reed, D. J., 1995, Cystathionine, Methods Enzymol. 252:92–102.

    CAS  PubMed  Google Scholar 

  • Reiter, R. J., 1980, The pineal and its hormones in the control of reproductive physiology in mammals, Endocrine Rev. 1:109–131.

    CAS  Google Scholar 

  • Reiter, R. J., Melchiorri, D., Sewerynek, E., Poeggeler, B., Barlow-Walden, L. R., Chuang, J., Ortiz, G. G., and Acuna-Castroviejo, D., 1995, A review of the evidence supporting melatonin’s role as an antioxidant, J. Pineal Res. 18:1–11.

    CAS  PubMed  Google Scholar 

  • Rice-Evans, C., and Miller, N. J., 1994, Total antioxidative status in plasma and body fluids, Methods Enzymol. 234:279–293.

    CAS  PubMed  Google Scholar 

  • Rusakow, L. S., White, C. W., and Stabler, S. P., 1993, O2-induced changes in lung and storage poolthiols in mice: Effects of superoxide dismutase, J. Appl. Physiol. 74:989–999.

    CAS  PubMed  Google Scholar 

  • Sainz, R. M., Mayo, J. C., Uria, H., Kotler, M., Antolin, I., Rodriguez, C., and Menendez-Peleaz, A., 1995, The pineal hormone melatonin prevents in vivo and in vitro apoptosis in thymocytes, J. Pineal Res. 19:178–188.

    CAS  PubMed  Google Scholar 

  • Sewerynek, E., Melchiorri, D., Ortiz, G. G., Poeggeler, B., and Reiter, R. J., 1995a, Melatonin reduces H2O2 induced lipid peroxidation in homogenates of different rat brain regions, J. Pineal Res. 19:51–56.

    CAS  PubMed  Google Scholar 

  • Sewerynek, E., Melchiorri, D., Reiter, R. J., Ortiz, G., and Lewinski, A., 1995b, Lipopolysaccharide-induced hepatotoxicity is inhibited by the antioxidant melatonin, Eur. J. Pharmacol. Environ. Toxicol. Pharmacol. Sect. 293:327–334.

    CAS  Google Scholar 

  • Sewerynek, E., Poeggeler, B., Melchiorri, D., and Reiter, R. J., 1995c, H2O2-induced lipid peroxidation in rat brain homogenates is greatly reduced by melatonin, Neurosci. Lett. 195:203–205.

    Article  CAS  PubMed  Google Scholar 

  • Shigenaga, M. K., Hagen, T. M., and Ames, B. A., 1994, Oxidative damage and mitochondrial decay in aging, Proc. Natl. Acad. Sci. USA 91:10771–10778.

    CAS  PubMed  Google Scholar 

  • Sohal, R. S., and Weinbruch, R., 1996, Oxidative stress, caloric restriction, and aging, Science 273:59–63.

    CAS  PubMed  Google Scholar 

  • Tallan, H., Moore, S., and Stein, W. H., l957, L-Cystathionine in human brain, J. Biol. Chem. 230:707–716.

    Google Scholar 

  • Tan, D.-X., Chen, L.-D., Poeggeler, B., Manchester, L. C., and Reiter, R. J., 1993a, Melatonin: A potent, endogenous hydroxyl radical scavenger, Endocrine J. 1:57–60.

    Google Scholar 

  • Tan, %D.-X., Poeggeler, B., Reiter, R. J., Chen, L.-D., Chen, S., Manchester, L. C., and Barlow-Walden, L. R., 1993b, The pineal hormone melatonin inhibits DNA adduct formation induced by the chemical carcinogen safrole, Cancer Lett. 70:65–71.

    Article  CAS  PubMed  Google Scholar 

  • Tan, D.-X., Reiter, R. J., Chen, L.-D., Poeggeler, B., Manchester, L. C., and Barlow-Walden, L. R., 1994, Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole, Carcinogenesis 15:215–218.

    CAS  PubMed  Google Scholar 

  • Thomas, J. N., and Smith-Sonneborn, J., 1996, Supplemental melatonin increases clonal lifespan in Paramecium tetraaurelia, Gerontologist 36:204.

    Google Scholar 

  • Tilden, A. R., Becker, M A., Amma, L. L., Arciniega, J., and McGaw, A. K., 1997, Melatonin production in an aerobic photosynthetic bacteria: An evolutionary early association with darkness, J. Pineal Res. 22:102–106.

    CAS  PubMed  Google Scholar 

  • Wada, K., Kamisaki, Y., Kitano, M., Nakamoto, K., and Itoh, T., 1995, Protective effect of cystathionine on acute gastric mucosal injury induced by ischemia-reperfusion in rats, Eur. J.Pharmacol. 294:377–382.

    Article  CAS  PubMed  Google Scholar 

  • Wada, K., Kamisaki, Y., Nakamoto, K., and Toh, T., 1996, Effect of cystathionine as a scavenger of superoxide generated from human leukocytes or derived from xanthine oxidase in vitro, Eur. J. Pharmacol. 296:335–340.

    Article  CAS  PubMed  Google Scholar 

  • Yu, B. P., 1994, Cellular defenses against damage from reactive oxygen species, Physiol. Rev. 74:139–161.

    CAS  PubMed  Google Scholar 

  • Zhang, J.-R., Andrus, P. K., and Hall, E. D., 1993, Age-related regional changes in hydroxyl radical stress and antioxidants in gerbil brain, J. Neurochem. 61:1640–1647.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, University of South Alabama, Mobile, Alabama, 36617

    Burkhard Poeggeler

Authors
  1. Burkhard Poeggeler
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Poeggeler, B. (2002). Melatonin Antioxidative Protection by Electron Donation. In: Reactive Oxygen Species in Biological Systems. Springer, Boston, MA. https://doi.org/10.1007/0-306-46806-9_16

Download citation

  • DOI: https://doi.org/10.1007/0-306-46806-9_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-45756-2

  • Online ISBN: 978-0-306-46806-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation