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Multiple Emulsions for the Delivery of Proteins

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Protein Delivery

Part of the book series: Pharmaceutical Biotechnology ((PBIO,volume 10))

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References

  • Aitken, I. D., 1973, The serological response of the chicken to a protein antigen in multiple emulsion oil adjuvant, Immunology 25:957–966.

    Google Scholar 

  • Blackall, P. J., Eaves, L. E., Rogers, D. G., and Firth, G., 1992, An evaluation of inactivated infectious Coryza vaccines containing a double-emulsion adjuvant system, Avian Dis. 36:632–636.

    Google Scholar 

  • Brodin, A. F., Kavaliunas, D. R., and Frank, S. G., 1978, Prolonged release from multiple emulsions, Acta Pharm. Suec. 15:1–12

    Google Scholar 

  • Chatenay, D., Urbach, W., Cazabat, A. M., Vacher, M., and Waks, M., 1985, Proteins in membrane mimetic systems. Insertion of myelin basic protein into microemulsion droplets, Biophys. J. 48:893–898.

    Google Scholar 

  • Chiou, W. L., and Reigelman, S., 1971, Pharmaceutical applications of solid dispersion systems, J. Pharm. Sci. 60:9281–1302.

    Google Scholar 

  • Davis, S. S., and Burbage, A. S., 1977, Electron microsopy of water-in-oil-in-water emulsions, J. Colloid Interface Sci. 62:361–363.

    Google Scholar 

  • Davis, S. S., Purewal, T. S., and Burbage, A. S., 1976, The particle size analysis of multiple emulsions, J. Pharm. Pharmacal. Suppl. 28:60P.

    Google Scholar 

  • Davis, T. A., Asher, W. J., and Wallace, H. W., 1984, Artificial red blood cells with crosslinked hemoglobin membranes, Appl. Biochem. Biotechnol. 10:123–132.

    Google Scholar 

  • Engel, R. H., Riggi, S. J., and Fahrenbach, M. J., 1968, Insulin: Intestinal absorption as water-in-oil-in-water emulsions, Nature 219:856–857.

    Google Scholar 

  • Florence, A. T., and Whitehill, D., 1980, Multiple W/O/W emulsions stabilized with poloxamer and acrylamide gels, J. Pharm. Pharmacol. 32:64P.

    Google Scholar 

  • Florence, A. T., and Whitehill, D., 1981, Some features of breakdown in water-in-oil-in-water multiple emulsions, J. Colloid Interface Sci. 79:243–256.

    Google Scholar 

  • Florence, A. T., and Whitehill, D., 1982, Stabilization of water/oil/water multiple emulsions by polymerization of aqueous phase, J. Pharm. Pharmacol. 34:687–691.

    Google Scholar 

  • Geary, R. S., and Schlameus, H. W., 1993, Vancomycin and insulin used as models for oral delivery of peptides, J. Controlled Release 23:65–74.

    Google Scholar 

  • Guyton, A. C., 1981, Textbook of Medical Physiology, Sixth ed., W. B. Saunders Co., Philidelphia, pp. 872–873.

    Google Scholar 

  • Herbert, W. J., 1965, Multiple emulsions. A new form of mineral-oil antigen adjuvant, Lancet 1965:771.

    Google Scholar 

  • Kita, Y., Masumoto, S., and Yonezawa, D., 1977a, Viscometric method for estimating the stability of w/o/w multiple-phase emulsions, J. Colloid Interface Sci. 62:745–751.

    Google Scholar 

  • Kita, Y., Masumoto, S., and Yonezawa, D., 1977b, An attempt at measuring the stability of w/o/w-type multiple phase emulsions by analyzing the concentration of anions, Nippon Kagaku Kaishi 6:748.

    Google Scholar 

  • Law, T. K., Whateley, T. L., and Florence, A. T., 1986, Stabilization of W/O/W multiple emulsions by interfacial complexation of macromolecules and nonionic surfactants, J. Controlled Release 3279–290.

    Google Scholar 

  • Lin, T. J., Kurihara, H., and Ohta, H., 1973, Effect of surfactant migration on the stability of emulsions, J. Soc. Cosmet. Chem. 24:797–814.

    Google Scholar 

  • Magdassi, S., Frenkel, M., Garti, N., and Kasan, R., 1984, Multiple emulsions II: HLB shift caused by emulsifier migration to external interface, J. Colloid Interface Sci. 97:374–379.

    Google Scholar 

  • Matsumoto, S., and Kohda, M., 1980, The viscosity of water-in-oil-in-water emulsions: An attempt to estimate the water permeation coefficient of the oil layer from the viscosity changes in diluted systems on ageing under osmotic pressure gradients, J. Colloid Interface Sci. 73:13–20.

    Google Scholar 

  • May, S. W., and Li, N. N., 1972, The immobilization of urease using liquid-surfactant membranes, Biochem. Biophys. Res. Commun. 47:1179–1185.

    Google Scholar 

  • Myers, S. L., and Shively, M. L., 1992, Preparation and characterization of emulsifiable glasses: Oil-in-water and water-in-oil-in-water emulsions, J. Colloid Interface Sci. 149:271–278.

    Google Scholar 

  • Myers, S. L., and Shively, M. L., 1993, Solid state emulsions: The effects of maltodextrin on microcrystalline aging, Pharm. Res. 10:1389–1391.

    Google Scholar 

  • Nianxi, Y., Mingzu, Z., and Peihong, N., 1992, A study of the stability of W/O/W multiple emulsions, J. Microencapsul. 9:143–151.

    Google Scholar 

  • Omotosho, J. A., Florence, A. T., and Whateley, T. L., 1990, Absorption and lymphatic uptake of 5-fluorouracil in the rat following oral administration of W/O/W multiple emulsions, Int. J. Pharm. 61:51–56.

    Google Scholar 

  • Scheper, T., Makryaleas, K., Nowottny, C., Likidis, Z., Tsikas, D., and Schugerl, K., 1987, Liquid surfactant membrane emulsions. A new technique for enzyme immobilization, Ann. N. Y. Acad. Sci. 501:165–170.

    Google Scholar 

  • Shichiri, M., Shimizu, Y., Yoshida, Y., Kawamori, R., Fukuchi, M., Shigeta, Y., and Abe, H., 1974, Enteral absorption of water-in-oil-in-water insulin emulsions in rabbits, Diabetologia 10:317–321.

    Google Scholar 

  • Shively, M. L., 1993a, Characterization of oil-in-water emulsions prepared from solid-state emulsions: Effect of matrix and oil phase, Pharm. Res. 10:1153–1156.

    Google Scholar 

  • Shively, M. L., 1993b, Droplet size distribution within oil-in-water emulsions prepared from solid-state dispersions, J. Coll. Interface Sci. 155:66–69.

    Google Scholar 

  • Shively, M. L., and Dec, S. F., 1994, Solid state emulsions: Evaluation by 1H and 13C solid-state nuclear magnetic resonance, Pharm. Res. 11:1301–1305.

    Google Scholar 

  • Shively, M. L., and Myers, S. L., 1993, Solid state emulsions: The effects of process and storage conditions, Pharm. Res. 10:1071–1075.

    Google Scholar 

  • Shively, M. L., and Thompson, D. C., 1995, Oral bioavailability of vancomycin solid-state emulsions, Int. J. Pharm. 117:119–122

    Google Scholar 

  • Szebeni, J. Winterbourn, C. C., and Carrell, R. W., 1984, Oxidative interactions between hemoglobin and membrane lipid. A liposome model, Biochem. J. 220:685–692.

    Google Scholar 

  • Szebeni, J., Hauser, H., Eskelson, C. D., Waston, R. R., and Winterhalter, K. H., 1988, Interaction of hemoglobin derivatives with liposomes. Membrane cholesterol protects against the changes of hemoglobin, Biochemistry 27:6425–6434.

    Google Scholar 

  • Takemoto, K., and Sonoda, N., 1984, Inclusion compounds in urea, thiourea and selenourea, in: Inclusion Compounds: Structural Aspects of Inclusion Compounds Formed by Organic Host Lattices, Vol. 2 (J. L. Atwood, J. E. D. Davies, and D. D. MacNicol, eds.), Academic Press, New York, pp. 47–67.

    Google Scholar 

  • Washington, C., 1990, The stability of intravenous fat emulsions in total parenteral nutrition mixtures, Int. J. Pharm., 66:1–21.

    Google Scholar 

  • Weiner, N., 1986, Strategies for formulation and evaluation of emulsions and suspensions: Some thermodynamic considerations, Drug Dev. Ind. Pharm. 12:933–951.

    Google Scholar 

  • Zheng, S., Zheng, Y., Beissinger, R., Wasan, D. T., and McCormick, D. L., 1993, Hemoglobin multiple emulsion as an oxygen delivery system, Biochim. Biophys. Acta 1158:65–74.

    Google Scholar 

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© 2002 Kluwer Academic Publishers

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Shively, M.L. (2002). Multiple Emulsions for the Delivery of Proteins. In: Sanders, L.M., Hendren, R.W. (eds) Protein Delivery. Pharmaceutical Biotechnology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/0-306-46803-4_7

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  • DOI: https://doi.org/10.1007/0-306-46803-4_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-45359-5

  • Online ISBN: 978-0-306-46803-2

  • eBook Packages: Springer Book Archive

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