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Diffusion-Controlled Delivery of Proteins from Hydrogels and Other Hydrophilic Systems

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Protein Delivery

Part of the book series: Pharmaceutical Biotechnology ((PBIO,volume 10))

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References

  • Adam, M., Delsanti, M., and Jannink, G., 1976, Light scattering by cooperative diffusion in semi-dilute polymer solutions, J. Phys, Lett. 37:153–156.

    Google Scholar 

  • am Ende, M. T., 1993, Transport and Interaction of Ionizable Drugs and Proteins in Hydrophilic Polymers. Ph.D. Thesis, Purdue University.

    Google Scholar 

  • Amis, E. J., Janmey, P. A., Ferry, J. D., and Yu, J., 1983, Quasi-elastic light scattering of gelatin solutions and gels, Macromolecules 16:441–446.

    Google Scholar 

  • Arteaga, C. L., Hurd, S. D., Dugger, R. C., Winnier, A. R., and Robertson, J. B., 1994, Epidermal growth factor receptors in human breast carcinoma cells: A potential selective target for transforming growth factor a-Pseudomonas exotoxin 40 fusion protein, Cancer Res. 54:703–4709.

    Google Scholar 

  • Baker, R., 1987, Controlled Release of Biologically Active Agents, John Wiley & Sons, New York.

    Google Scholar 

  • Berens, A. R., and Hofenberg, H. B., 1978, Diffusion and relaxation in glassy polymer powders: 2. Separation of diffusion and relaxation parameters, Polymer 19:490–496.

    Google Scholar 

  • Braatz, J. A., Heifetz, A. H., and Kehr, C. L., 1992, A new hydrophilic polymer for biomaterial coatings with low protein adsorption. J. Biomater. Sci. Polym Ed 3(6):451–462.

    Google Scholar 

  • Brondsted, H., and Kopecek, J., 1991, Hydrogels for site-specific oral drug delivery: Synthesis and characterization Biomaterials 12:584–592.

    Google Scholar 

  • Bueche, F., 1962, Physical Properties of Polymers, Interscience Publishers, New York.

    Google Scholar 

  • Caliceti, P., Veronese, F., Schiavon, O., Lora, S., and Carenza, M., 1992, Controlled release of proteins and peptides from hydrogels synthesized by gamma ray-induced polymerization, II Farmaco 47(3):275–286.

    Google Scholar 

  • Canal, T., and Peppas, N. A., 1989, Correlation between mesh size and equilibrium degree of swelling of polymeric networks, J. Biomed Mater. Res. 23:1183–1193.

    Google Scholar 

  • Carelli, V., Di Colo, G., Nannipieri, E., and Serafini, M.F., 1989, Evaluation of solution impregnation method for loading drugs into suspension-type polymer matrices: A study of factors determining the patterns of solid drug distribution in matrix and drug release from matrix, Int. J. Pharm. 55:199–207.

    Google Scholar 

  • Colton, C. K., Smith, K. A., Merrill, E. W., and Farrell, P. C., 1971, Permeability studies with cellulosic membranes, J. Biomed. Mater. Res. 5:459–488.

    Google Scholar 

  • Crank, J., 1975, The Mathematics of Diffusion, Academic Press, New York.

    Google Scholar 

  • Crank, J., and Park, G. S., 1968, Diffusion in Polymers, Academic Press, New York.

    Google Scholar 

  • de Gennes, P. G., 1979, Scaling Concepts in Polymer Physics, Cornell University Press, Ithaca, New York.

    Google Scholar 

  • Dillman, W. J., Jr., and Miller, I. F., 1973, On the adsorption of serum proteins on polymer membrane surfaces, J. Cotloid. Interface Sci. 44:221–241.

    Google Scholar 

  • Domb, A., Davidson, G. W. R., III, and Sanders, L. M., 1990, Diffusion of peptides through hydrogel membranes, J. Controlled Release 14:133–144.

    Google Scholar 

  • Dong, L. C., and Hoffman, A. S., 1991, A novel approach for preparation of pH sensitive hydrogels for enteric drug delivery, J. Controlled Release 15:141–152.

    Google Scholar 

  • Greenley, R. Z., Brown, R. M., Garbow, J., Vogt, C. E., Zia, H., Rodgers, R. L., Christie, M., and Luzzi, L. A., 1990, Polymer matrices for oral delivery Polym. Prep. (Am. Chem. Soc., Div. Polym. Chem.) 31(2):182–183.

    Google Scholar 

  • Hayashi, Y., Yoshioka, S., Aso, Y., Po, A. L. W., and Terao, T., 1994, Entrapment of proteins in poly(L-lactide) microspheres using reversed micelle solvent evaporation Pharm.Res. 11(2):337–340.

    Google Scholar 

  • Heller, J., 1988, Chemically self-regulated drug delivery systems, J. Controlled Release 8:111–125.

    Google Scholar 

  • Ho, N. F. H., Ganesan, M. G., Weiner, N. D., and Flynn, G. L., 1986, Mechanisms of topical delivery of liposomally entrapped drugs, in: Advances in Drug Delivery Systems (J. M. Anderson and S. W. Kim, eds.), Controlled Release Series No. 1, Elsevier, New York, pp. 61–65.

    Google Scholar 

  • Horbett, T. A., 1982, Protein adsorption on biomaterials, in: Biomaterials: Interfacial Phenomena and Applications (S. L. Cooper, N. A. Peppas, A. S. Hoffman, and B. D. Ratner, eds.), Advances in Chemistry Series No. 199, American Chemical Society, Washington, D.C., pp. 233–244.

    Google Scholar 

  • Hsieh, D. S. T., Rhine, W. D., and Langer, R., 1983, Zero-order controlled release polymer matrices for micro-and macromolecules, J. Pharm. Sci.. 72(1):17–22.

    Google Scholar 

  • Jabbari, E., Wisniewski, N., and Peppas, N. A., 1993, Evidence of mucoadhesion by chain interpenetration at a poly(acrylic acid)/mucin interface using ATR-FTIR spectroscopy, J. ControlledRelease 26:99–108.

    Google Scholar 

  • Jeffery, H., Davis, S. S., and O’Hagen, D. T., 1993, The preparation and characterization of poly(lactide-co-glycolide) microparticles. II. The entrapment of a model protein using a (water-in-oil)-in-water emulsion solvent evaporation technique, Pharm. Res. 10:362–368.

    Google Scholar 

  • Kim, C. J., and Lee, P. I., 1991, Swelling-controlled drug release from anionic polyelectrolyte gel beads, Proc. Int. Symp. Control. Rel. Bioact. Mater. 18:451–452.

    Google Scholar 

  • Kopecek, J., Kopeckova, P., Brondsted, H., Rathi, R., Rihova, B., Yen, P.-Y., and Ikesue, K., 1992, Polymers for colon-specific drug delivery, J. Controlled Release 19:121–130.

    Google Scholar 

  • Korsmeyer, R. W., 1991, Diffusion controlled systems: Hydrogels, in: Polymers for Controlled Drug Delivery (P. J. Tarcha, ed.), CRC Press, Boca Raton, Florida, pp. 15–37.

    Google Scholar 

  • Langer, R., 1990, New methods of drug delivery, Science 249:1527–1533.

    Google Scholar 

  • Langer, R., and Folkman, J., 1976, Polymers for the sustained release of proteins and other macromolecules, Nature 263:797–800.

    Google Scholar 

  • Langer, R., and Peppas, N., 1983, Chemical and physical structure of polymers as carriers for controlled release of bioactive agents: A review, J. Mater. Sci.: Rev. Macromol. Chem. Phys. C23(1):61–126.

    Google Scholar 

  • Lee, P. I., 1988, Synthetic hydrogels for drug delivery: Preparation, characterization, and release kinetics, in: Controlled Release Systems: Fabrication Technology, Vol. II (D. S. T. Hsieh, ed.), CRC Press, Boca Raton, Florida, pp. 61–82.

    Google Scholar 

  • Lee, V. H. L., 1992, Peptide and Protein Drug Delivery, Marcel Dekker, New York.

    Google Scholar 

  • McGee, J. P., Davis, S. S., and O’Hagan, D. T., 1995, Zero order release of protein from poly(D,L-lactide-co-glycolide) microparticles prepared using a modified phase separation technique, J. Controlled Release 34:17–86.

    Google Scholar 

  • McNeill, M. E., and Graham, N. B., 1993, Properties controlling the diffusion and release of water-soluble solutes from poly(ethylene oxide) hydrogels 1. Polymer composition, J. Biomater. Sci Polym. Ed. 4:305–322.

    Google Scholar 

  • Munch, J. P., Candau, S., Duplexxis, R., Picot, C., Herz, J., and Benoit, H., 1976, Spectrum of light scattered from viscoelastic gels, J. Polym. Sci.: Polym. Phys. Ed. 14:1097–1109.

    Google Scholar 

  • Park, K., 1988, Enzyme-digestible swelling hydrogels as platforms for long-term oral drug delivery: Synthesis and characterization, Biomaterials 9:435–441.

    Google Scholar 

  • Patterson, G. D., 1981, Light scattering from concentrated polymer solutions and gels, Polym. Prepr. Am. Chem. Soc., Div. Polym. Chem. 22:709–713.

    Google Scholar 

  • Peppas, N. A., and Lustig, S. R., 1985, The role of cross-links, entanglements, and relaxations of macromolecular carriers in the diffusional release of biologically active materials: Conceptual and scaling relationships, Ann. N. Y. Acad Sci. 446:26–41.

    Google Scholar 

  • Peppas, N. A., and Meadows, D. L., 1983, Macromolecular structure and solute diffusion in membranes: An overview of recent theories, J. Membr. Sci. 16361–377.

    Google Scholar 

  • Peschier, L. J. C., Bouwstra, J. A., de Bleyser, J., Junginger, H. E., and Leyte, J. C., 1993, Water mobility and structure in poly[2-hydroxyethylmethacrylate] hydrogels by means of the pulsed field gradient NMR technique, Biomaterials 14:945–952.

    Google Scholar 

  • Price, F. P., Gilmore, P. T., Thomas, E. L., and Laurence, R. L., 1978, Polymer/polymer diffusion, J. Polym. Sci.: Polym. Symp. 63:33–44.

    Google Scholar 

  • Rabek, J. F., 1980, Experimental Methods in Polymer Chemistry: Physical Principles and Applications, John Wiley & Sons, New York.

    Google Scholar 

  • Ritger, P. L., and Peppas, N. A., 1987, A simple equation for description of solute release I. Fickian and non-Fickian release from non-swellable devices in the form of slabs, spheres, cylinders, or discs, J. Controlled Release 5:23–36.

    Google Scholar 

  • Roorda, W., 1994, Do hydrogels contain different classes of water?, J. Biomater. Sci. Polym. Ed. 5:383–395.

    Google Scholar 

  • Sahlin, J. J., 1992, Polymer Chain Interdiffusion in Gel/Gel Adhesion, Ph.D. thesis, Purdue University.

    Google Scholar 

  • Sato, S., and Kim, S. W., 1984, Macromolecular diffusion through polymer membranes, Int. J. Pharm.22:229–255.

    Google Scholar 

  • Satterfield, C. N., Colton, C. K., and Pitcher, W. H., Jr., 1973, Restricted diffusion of liquids within fine pores, AIChE J. 19:628–635

    Google Scholar 

  • Sawhney, A. S., Pathak, C. P., and Hubbell, J. A., 1993, Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-(a-hydroxy acid) diacrylate macromers, Macromolecules 26:581–587.

    Google Scholar 

  • Shah, S. S., Cha, Y., and Pitt, C. G., 1992, Poly(glycolic acid-co-DL-lactic acid): Diffusion or degradation controlled drug delivery?, J. Controlled Release 18:261–270.

    Google Scholar 

  • Shalaby, W. S., and Park, K., 1990, Biochemical and mechanical characterization of enzyme-digestible hydrogels, Pharm. Res. 7:816–823.

    Google Scholar 

  • Shalaby, W. S. W., Abdallah, A. A., Park, H., and Park, K., 1993, Loading of bovine serum albumin into hydrogels by an electrophoretic process and its potential application to protein drugs, Pharm. Res. 10(3):457–460.

    Google Scholar 

  • Siegel, R. A., and Langer, R., 1984, Controlled release of polypeptides and other macromolecules, Pharm. Res. 1:2–10.

    Google Scholar 

  • Smith, B. A., and Sefton, M. V., 1992, Thrombin and albumin adsorption to PVA and heparin-PVA hydrogels. I. Single protein isotherms, J. Biomed. Mater. Res. 26:947–958.

    Google Scholar 

  • Smith, K. L., Baker, R. W., and Ninomiya, Y., 1983, Development of BioLure controlled release pheromone products, in: Controlled Release Delivery Systems (T. J. Roseman and S. Z. Mansdorf, eds.), Marcel Dekker, New York, pp. 325–335.

    Google Scholar 

  • Stock, R. S., and Ray, W. H., 1985, Interpretation of photon correlation spectroscopy data: A comparison of analysis methods, J. Polym. Sci.: Polym. Phys. Ed 23:1393–1447.

    Google Scholar 

  • Strzinar, I., and Sefton, M. V., 1992, Preparation and thrombogenicity of alkylated polyvinyl alcohol coated tubing, J. Biomed Mater. Res. 26:577–592.

    Google Scholar 

  • Suzawa, T., and Murakami, T., 1980, Adsorption of bovine serum albumin on synthetic polymer latices, J. Colloid Interface Sci. 78(1):267–268.

    Google Scholar 

  • Theeuwes, F., 1975, Elementary osmotic pump, J. Pharm. Sci. 64:1987–1991.

    Google Scholar 

  • Thissen, J. P., Underwood, L. E., Maiter, D., Maes, M., Clemmons, D. R., and Ketelslegers, J.M., 1991, Failure of insulin-like growth factor-I (IGF-I) infusion to promote growth in protein-restricted rats despite normalization of serum IGF-I concentrations, Endocrinology 128:885–890.

    Google Scholar 

  • Zentner, G. M., Cardinal, J. R., and Gregonis, D. E., 1979, Progestin permeation through polymer membranes III: Polymerization solvent effect on progesterone permeation through hydrogel membranes, J. Pharm. Sci. 68(6):794–797.

    Google Scholar 

  • Zhu, K. J., Xiangzhou, L., and Shih, Y., 1990, Preparation, characterization, and properties of polylactide (PLA)-poly(ethylene glycol) (PEG) copolymers: A potential drug carrier, J. Appl. Polym. Sci. 39:1–9.

    Google Scholar 

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am Ende, M.T., Mikos, A.G. (2002). Diffusion-Controlled Delivery of Proteins from Hydrogels and Other Hydrophilic Systems. In: Sanders, L.M., Hendren, R.W. (eds) Protein Delivery. Pharmaceutical Biotechnology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/0-306-46803-4_5

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  • DOI: https://doi.org/10.1007/0-306-46803-4_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-45359-5

  • Online ISBN: 978-0-306-46803-2

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