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Delivery of Proteins from a Controlled Release Injectable Implant

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References

  • Bartsch, W., Sponer, G., Dietmann, D., and Fuchs, G., 1976, Acute toxicity of various solvents in the mouse and rat. Use of ethanol, dimethylacetamide, dimethylformamide, dimethylsulfoxide, glycerine, N-methylpyrrolidone, polyethylene glycol 400, 1,2-propanediol and Tween 20, Arzneim-Forsch. 26:1581–1583.

    CAS  Google Scholar 

  • Bodmer, D., Kissell, T., and Traechslin, E., 1992, Factors influencing the release of peptides and proteins from biodegradable parenteral depot systems, J. Controlled Release 21:129–138.

    Google Scholar 

  • Brady, J. M., Cutright, D. E., Miller, R. A., Battistone, G. C., and Hunsuck, E. E., 1973, Resorption rate, route of elimination and ultrastructure of the implant site of polylactic acid in the abdominal wall of the rat, J. Biomed Mater. Res. 7:155–166.

    Google Scholar 

  • Brady, J. M., Cutright, D. E., Miller, R. A., Battistone, G. C., and Hunsuck, E. E., 1973. Resorption rate, rounte of elimination and ultrastructure of the implant site of polylactic acid in the abdominal wall of the rat, J. Biomed Mater. Res. 7:155–166.

    Google Scholar 

  • Center for Devices and Radiological Health, 1993, Tripartite biocompatibility testing guidelines, Division of Small Manufacturers Assistance, Food and Drug Administration, Washington, D.C.

    Google Scholar 

  • Chavira, R., Jr., Burnett, T. J. and Hageman, J. H., 1984, Assaying proteinases with azocoll, Anal. Biochem. 136:446–450.

    Google Scholar 

  • Cutright, D. E., Beasley, J. D., 111, and Perez, B., 1971, Histologic comparison of polylactic and polyglycolic acid sutures, Oral Surg. 32:165–173.

    Google Scholar 

  • David, N. A., 1972, The pharmacology of dimethyl sulfoxide, Annu. Rev. Pharm. 12:353–374.

    Google Scholar 

  • Draize, J. H., 1959, The Appraisal of Chemicals in Foods, Drugs and Cosmetics, Association of Food and Drug Officials of the United States, Austin, Texas, pp. 46–59.

    Google Scholar 

  • Dunn, R. L., Yewey, G. L., and Tipton, A. J., 1992, An injectable implant delivery system for tissue growth factors, American Association of Pharmaceutical Scientists Western Regional Meeting, Las Vegas.

    Google Scholar 

  • Freshney, R. I., 1994, Culture of Animal Cells, Wiley-Liss, New York, pp. 296–299.

    Google Scholar 

  • Gearing, A. J. H., and Bird, C. B., 1987, Production and assay of interleukine 2, in: Lymphokines and Interferons, A Practical Approach, (M. J. Clements, A. G. Morris, and A. J. H. Gearing, eds.) IRL Press, Oxford, England, pp. 281–301.

    Google Scholar 

  • Gilding, D. K., 1981, Degradation of polymers: Mechanisms and implications for biomedical applications, in: Fundamental Aspects of Biocompatibility, Vol. 1 (D. F. Williams, ed.), CRC Press, Boca Raton, Florida, pp. 44–65.

    Google Scholar 

  • Gourlay, S. J., Rice, R. M., Hegyeli, A. F., Wade, C. W. R., Dillon J. C., Jaffe, H., and Kulkami, R. K., 1978, Biocompatibility testing of polymers: In vivo implantation studies. J. Biomed. Mater. Res. 12:219–232.

    Google Scholar 

  • Hames, B. D. and Richwood, D., 1990, Gel Electrophoresis of Proteins, A Practical Approach, IRL Press, Oxford, England, p. 16.

    Google Scholar 

  • Hollinger, J. O., and Battistone, G. C., 1986, Biodegradable bone repair materials. Clin. Orthop. Relat. Res. 207:290–305.

    Google Scholar 

  • Jacob, S. W., and Wood, D. C., 1971, Dimethyl sulfoxide—A status report, Clin. Med. 78:21–31.

    Google Scholar 

  • Kulkarni, R. K., Moore, E. G., Hegyeli, A. F., and Leonard, F., 1971, Biodegradable poly(lactic acid) polymers, J. Biomed. Mater. Res. 5:169–181.

    Google Scholar 

  • Laemmli, U. K., 1970, Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature 227:680–685.

    Google Scholar 

  • Matthews, N., and Neale, M. L., 1987, Cytotoxicity assays for tumour necrosis factor and lymphotoxin, in: Lymphokines and Interferons, a Practical Approach, (M. J. Clemens, A. G. Morris, and A. J. H. Gearing, eds.) IRL Press, Oxford, pp. 221–225.

    Google Scholar 

  • Nakamura, T., Hitomi, S., Watanabe, S., Shimizu, Y., Jamshidi, K., Hyon, S. H., and Ikada, Y., 1989, Bioabsorption of polylactides with different molecular properties, J. Biomed. Mater. Res. 23:1115–1130.

    Google Scholar 

  • Ohsawa, K., and Ebata, N., 1983, Silver stain for detecting 10 femtogram quantities of protein after polyacrylamide gel electrophoresis, Anal. Biochem., 135:409–415.

    Google Scholar 

  • Radomsky, M. L., Brouwer, G., Floy, B. J., Loury, D. J., Chu, F., Tipton, A. J., and Sanders, L. M., 1993, The controlled release of ganirelix from the ATRIGEL™ injectable implant system, Proc. Int. Symp. Control. Rel. Bioact. Mater. 20:458–459.

    Google Scholar 

  • Raines, E., and Ross, R., 1985, Purification of human plateletderived growth factor, Methods Enzymol. 109:749–112.

    Google Scholar 

  • Rice, R. M., Hegyeli, A. F., Gourlay, S. J., Wade, C. W. R., Dillon, J. C., Jaffe, H., and Kulkarni, R.K., 1978, Biocompatibility testing of polymers: In vitro studies with in vivo correlation, J. Biomed. Mater. Res. 12:43–54.

    Google Scholar 

  • Shirley, H. H., Lundergan, M. K., Williams, H. J., and Spruance, S. L., 1989, Lack of ocular changes with dimethylsulfoxide therapy of scleroderma, Pharmacotherapy 9:165–168.

    Google Scholar 

  • Somerman, M. J., Foster, R. A,, Vorsteg, G., Progebin, K., and Wynn, R. L., 1988, Effects of minocycline on fibroblast attachment and spreading, J. Periodont. Res. 23:154–159.

    Google Scholar 

  • Wells, D. A., and Digenis, G. A., 1988, Disposition and metabolism of double-labeled (3H and 14C) N-methyl-2-pyrrolidone in the rat, Drug Metab. Dispos. 16:243–249.

    Google Scholar 

  • Wells, D. A., Hawi, A. A., and Digenis, G. A., 1992, Isolation and identification of the major urinary metabolite of N-methylpyrrolidone in the rat, Drug Metab. Dispos. 20:124–126.

    Google Scholar 

  • Wilson, J. E., Brown, D. E., and Timmens, E. K., 1965, A toxicologic study of dimethyl sulfoxide, Toxicol. Appl. Pharmacol. 7:104–112.

    Google Scholar 

  • Woodward, S. C., Brewer, P. S., Moatamed, F., Schindler, A., and Pitt. C. C., 1985, The intracellular degradation of poly(e-caprolactone), J. Biomed. Mater. Res. 19:437–444.

    Google Scholar 

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© 2002 Kluwer Academic Publishers

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Yewey, G., Duysen, E.G., Cox, S.M., Dunn, R.L. (2002). Delivery of Proteins from a Controlled Release Injectable Implant. In: Sanders, L.M., Hendren, R.W. (eds) Protein Delivery. Pharmaceutical Biotechnology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/0-306-46803-4_3

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  • DOI: https://doi.org/10.1007/0-306-46803-4_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-45359-5

  • Online ISBN: 978-0-306-46803-2

  • eBook Packages: Springer Book Archive

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