Stereospecific Introduction of Cephalosporin Side Chains Employing Transition Metal Complexes
The unique structural and chemotherapeutic properties of β-lactams continue to attract the attention of synthetic community since they present a variety of challenges. To synthesize cephalosporins with enhanced biological properties, efforts were focused on the modifications of the C(3) position of cephems with all carbon substituents. For example, cephalosporins with olefinic and allylic side chains were found compatible with good, broad-spectrum activity with excellent pharmacokinetic profiles. Efficient and versatile synthetic approaches to these compounds with an aim of commercialization and study of structure-activity relationships therefore became highly desirable. The development of various organometallic methodologies for the stereospecific introduction of cephalosporin side chains has advanced remarkably in the last few years by keeping pace with fundamental research in organotransition chemistry. This chapter surveys some of these advances in the use of organotransition metal complexes to gain easy access to these novel cephalosporins.
KeywordsStereoselective Transition metal complex C-C Bond formation Cephalosporin Allene
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