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Development of Transition Metal-Mediated Cyclopropanation Reactions

  • Albert J. DelMonte
  • Eric D. Dowdy
  • Daniel J. WatsonEmail author
Chapter
Part of the Topics in Organometallic Chemistry book series (TOPORGAN, volume 6)

Abstract

A brief discussion of the methods for cyclopropane formation emphasizing organometallic reagents and catalysts is followed by several examples of the application of these methods in the manufacture of functional chemicals and pharmaceuticals. The unique challenges faced by scientists in a process environment will be emphasized.

Keywords

Asymmetric Catalysis Bisoxazoline Cyclopropanation Diazoacetate Pyrethroids 

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Authors and Affiliations

  • Albert J. DelMonte
    • 1
  • Eric D. Dowdy
    • 2
  • Daniel J. Watson
    • 1
    Email author
  1. 1.Department of Process Research and DevelopmentBristol-Myers SquibbNew BrunswickUSA
  2. 2.Department of Process ResearchGilead SciencesFoster CityUSA

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