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Applications of Organotitanium Reagents

  • David L. HughesEmail author
Chapter
Part of the Topics in Organometallic Chemistry book series (TOPORGAN, volume 6)

Abstract

Organometallic transformations involving titanium are employed both catalytically and stoichiometrically in the pharmaceutical and fine chemical industry. The current review outlines a number of examples of the industrial applications of organotitanium reagents over the past decade. In addition, several reactions are briefly reviewed for which no industrial applications have been reported, but for which commercial utility may be envisaged. The review is organized by reaction type: carbon-carbon bond formation, carbon-heteroatom bond formation, oxidations, reductions, and hydrolysis/ester formation.

Keywords

Organotitanium Asymmetric catalysis Pharmaceutical applications Oxidation Reduction 

List of Abbreviations

BINOL

1,1-Binaphth-2-ol

Cp

Cyclopentadienyl

de

Diasteromeric excess

ee

Enantiomeric excess

TADDOL

Tetraaryl-1,3-dioxolane-4,5-dimethanol

TMEDA

Tetramethylethylenediamine

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Authors and Affiliations

  1. 1.Department of Process ResearchMerck and Co. Inc.RahwayUSA

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