Advertisement

Disulfiram pp 51-58 | Cite as

Disulfiram and Its Use in Special Populations

  • Avinash De Sousa
Chapter
First Online:

Abstract

This chapter is devoted to discussing the use of disulfiram and reviewing studies of disulfiram in special populations. This includes the use of disulfiram in the elderly, adolescents, female patients with alcohol dependence and dual diagnosis or multi-drug user populations. The various studies done so far are evaluated and clinical points of relevance are discussed.

Keywords

Disulfiram Special populations Elderly Females Adolescents Dual diagnosis 
This is a preview of subscription content, log in to check access.

References

  1. 1.
    De Sousa A, Jagtap J. An open label trial of naltrexone versus disulfiram in elderly patients with alcohol dependence. J Pak Pychiatr Soc. 2009;6(2):85–9.Google Scholar
  2. 2.
    Menninger JA. Assessment and treatment of alcoholism and substance-related disorders in the elderly. Bull Menn Clin. 2002;66(2):166–83.CrossRefGoogle Scholar
  3. 3.
    Dar K. Alcohol use disorders in elderly people: fact or fiction? Adv Psychiatr Treat. 2006;12(3):173–81.CrossRefGoogle Scholar
  4. 4.
    Culberson J. Alcohol use in the elderly: beyond the CAGE. Geriatrics. 2006;61(10):23–7.PubMedGoogle Scholar
  5. 5.
    Lal R, Pattanayak RD. Alcohol use in the elderly: issues and considerations. J Geriatr Ment Health. 2017;4(1):4–10.CrossRefGoogle Scholar
  6. 6.
    Sarkar S, Parmar A, Chatterjee B. Substance use disorders in the elderly: a review. J Geriatr Ment Health. 2015;2(2):74–82.CrossRefGoogle Scholar
  7. 7.
    Ross S. Alcohol use disorders in the elderly. Prim Psychiatry. 2005;12(1):32–40.Google Scholar
  8. 8.
    Niederhofer H, Staffen W. Comparison of disulfiram and placebo in treatment of alcohol dependence of adolescents. Drug Alcohol Rev. 2003;22(3):295–7.CrossRefGoogle Scholar
  9. 9.
    De Sousa A, De Sousa A. An open randomized trial comparing disulfiram and naltrexone in adolescents with alcohol dependence. J Subst Use. 2008;13(6):382–8.CrossRefGoogle Scholar
  10. 10.
    Mutschler J, Grosshans M, Koopmann A, Hermann D, Diehl A, Mann K, Kiefer F. Supervised disulfiram in relapse prevention in alcohol-dependent patients suffering from comorbid borderline personality disorder—a case series. Alcohol Alcohol. 2010;45(2):146–50.CrossRefGoogle Scholar
  11. 11.
    Gunderson JG, Weinberg I, Choi-Kain L. Borderline personality disorder. Focus. 2013;11(2):129–45.CrossRefGoogle Scholar
  12. 12.
    Stepp SD, Trull TJ, Sher KJ. Borderline personality features predict alcohol use problems. J Pers Disord. 2005;19(6):711–22.CrossRefGoogle Scholar
  13. 13.
    DeVito EE, Babuscio TA, Nich C, Ball SA, Carroll KM. Gender differences in clinical outcomes for cocaine dependence: randomized clinical trials of behavioral therapy and disulfiram. Drug Alcohol Depend. 2014;145:156–67.CrossRefGoogle Scholar
  14. 14.
    Agabio R, Campesi I, Pisanu C, Gessa GL, Franconi F. Sex differences in substance use disorders: focus on side effects. Addict Biol. 2016;21(5):1030–42.CrossRefGoogle Scholar
  15. 15.
    Rayburn WF, Bogenschutz MP. Pharmacotherapy for pregnant women with addictions. Am J Obstetr Gynecol. 2004;191(6):1885–97.CrossRefGoogle Scholar
  16. 16.
    Helmbrecht GD, Hoskins IA. First trimester disulfiram exposure: report of two cases. Am J Perinatol. 1993;10(1):5–7.CrossRefGoogle Scholar
  17. 17.
    Reitnauer PJ, Callanan NP, Farber RA, Aylsworth AS. Prenatal exposure to disulfiram implicated in the cause of malformations in discordant monozygotic twins. Teratology. 1997;56(6):358–62.CrossRefGoogle Scholar
  18. 18.
    Nora A, Nora J, Blu J. Limb-reduction anomalies in infants born to disulfiram-treated alcoholic mothers. Lancet. 1977;310(8039):664.CrossRefGoogle Scholar
  19. 19.
    Drake RE, Essock SM, Shaner A, Carey KB, Minkoff K, Kola L, Lynde D, Osher FC, Clark RE, Rickards L. Implementing dual diagnosis services for clients with severe mental illness. Psychiatr Serv. 2001;52(4):469–76.CrossRefGoogle Scholar
  20. 20.
    Larson EW, Olincy A, Rummans TA, Morse RM. Disulfiram treatment of patients with both alcohol dependence and other psychiatric disorders: a review. Alcohol Clin Exp Res. 1992;16(1):125–30.CrossRefGoogle Scholar
  21. 21.
    Rossiter SK. Psychosis with disulfiram prescribed under probation order. BMJ. 1992;305(6856):763–4.CrossRefGoogle Scholar
  22. 22.
    Mueser KT, Noordsy DL, Fox L, Wolfe R. Disulfiram treatment for alcoholism in severe mental illness. Am J Addict. 2003;12(3):242–52.CrossRefGoogle Scholar
  23. 23.
    Petrakis IL, Poling J, Levinson C, Nich C, Carroll K, Rounsaville B, VA New England VISN I MIRECC Study Group. Naltrexone and disulfiram in patients with alcohol dependence and comorbid psychiatric disorders. Biol Psychiatry. 2005;57(10):1128–37.CrossRefGoogle Scholar
  24. 24.
    Petrakis I, Ralevski E, Nich C, Levinson C, Carroll K, Poling J, Rounsaville B, VA VISN I MIRECC Study Group. Naltrexone and disulfiram in patients with alcohol dependence and current depression. J Clin Psychopharmacol. 2007;27(2):160–5.CrossRefGoogle Scholar
  25. 25.
    Petrakis IL, Poling J, Levinson C, Nich C, Carroll K, Ralevski E, Rounsaville B. Naltrexone and disulfiram in patients with alcohol dependence and comorbid post-traumatic stress disorder. Biol Psychiatry. 2006;60(7):777–83.CrossRefGoogle Scholar
  26. 26.
    Kranzler HR, Rosenthal RN. Dual diagnosis: alcoholism and co-morbid psychiatric disorders. Am J Addict. 2003;12:26–40.CrossRefGoogle Scholar
  27. 27.
    Gual A. Dual diagnosis in Spain. Drug Alcohol Rev. 2007;26(1):65–71.CrossRefGoogle Scholar
  28. 28.
    Kingsbury SJ, Salzman C. Disulfiram in the treatment of alcoholic patients with schizophrenia. Psychiatr Serv. 1990;41(2):133–4.CrossRefGoogle Scholar
  29. 29.
    Petrakis IL, Nich C, Ralevski E. Psychotic spectrum disorders and alcohol abuse: a review of pharmacotherapeutic strategies and a report on the effectiveness of naltrexone and disulfiram. Schizophr Bull. 2006;32(4):644–54.CrossRefGoogle Scholar
  30. 30.
    Farren CK, Hill KP, Weiss RD. Bipolar disorder and alcohol use disorder: a review. Curr Psychiatry Rep. 2012;14(6):659–66.CrossRefGoogle Scholar
  31. 31.
    Petrakis IL, Carroll KM, Nich C, Gordon LT, McCance-Katz EF, Frankforter T, Rounsaville BJ. Disulfiram treatment for cocaine dependence in methadone-maintained opioid addicts. Addiction. 2000;95(2):219–28.CrossRefGoogle Scholar
  32. 32.
    George TP, Chawarski MC, Pakes J, Carroll KM, Kosten TR, Schottenfeld RS. Disulfiram versus placebo for cocaine dependence in buprenorphine-maintained subjects: a preliminary trial. Biol Psychiatry. 2000;47(12):1080–6.CrossRefGoogle Scholar
  33. 33.
    Oliveto A, Poling J, Mancino MJ, Feldman Z, Cubells JF, Pruzinsky R, Gonsai K, Cargile C, Sofuoglu M, Chopra MP, Gonzalez-Haddad G. Randomized, double blind, placebo-controlled trial of disulfiram for the treatment of cocaine dependence in methadone-stabilized patients. Drug Alcohol Depend. 2011;113(2–3):184–91.CrossRefGoogle Scholar
  34. 34.
    Farci AM, Piras S, Murgia M, Chessa A, Restivo A, Gessa GL, Agabio R. Disulfiram for binge eating disorder: an open trial. Eat Behav. 2015;16:84–7.CrossRefGoogle Scholar
  35. 35.
    Gilman S, Adams KM, Johnson-Greene D, Koeppe RA, Junck L, Kluin KJ, Martorello S, Heumann M, Hill E. Effects of disulfiram on positron emission tomography and neuropsychological studies in severe chronic alcoholism. Alcohol Clin Exp Res. 1996;20(8):1456–61.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Avinash De Sousa
    • 1
  1. 1.Department of PsychiatryLokmanya Tilak Muncipal Medical CollegeMumbaiIndia

Personalised recommendations

Cite chapter

Buy options