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Cancer Biology and Its Treatment Modalities: A Brief Historical Perspective

  • Aasna L. Parui
  • Kakoli BoseEmail author
Chapter

Abstract

For thousands of years, tremendous amount of research has been carried out to understand one of the leading causes of death – cancer. Being known for its complexity, researchers have put tremendous efforts in acquiring every bit of knowledge that is required to understand the distinct aspects of tumor biology, progression, invasion, and metastasis. These include understanding the tumor physiology, developing different detection techniques, as well as identifying the genetic roots of the disease. This in turn would help in unraveling the signaling circuitry that regulates intercommunication within the tumor microenvironment. The main objective of this chapter is to provide a comprehensive overview of the different historic events that have taken place in the field of cancer research. Besides, it also briefly describes the different hallmarks of cancer that have been put forth to elaborate the different mechanisms adapted by cancer cells for their survival and progression.

Keywords

Cancer Tumor biology Detection Signaling History Hallmarks of cancer 

References

  1. Benner J (2015) The history of cancer: a timeline [Online]. The rector and visitors of the University of Virginia. Available: https://blog.uvahealth.com/2015/03/12/history-cancer-timeline/. Accessed 10 Aug 2018
  2. Emory University Historical cancer highlights, CancerQuestGoogle Scholar
  3. Frank DA (2011) Signaling pathways in cancer pathogenesis and therapy. Springer, New YorkGoogle Scholar
  4. Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57–70CrossRefGoogle Scholar
  5. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674CrossRefGoogle Scholar
  6. Hunter T, Sefton BM (1980) Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proc Natl Acad Sci U S A 77:1311–1315CrossRefGoogle Scholar
  7. National Cancer Institute (2015) Milestones in cancer research and discovery [Online]. Available: https://www.cancer.gov/research/progress/250-years-milestones. Accessed 10 Aug 2018
  8. Sudhakar A (2009) History of cancer, ancient and modern treatment methods. J Cancer Sci Ther 1:1–4CrossRefGoogle Scholar
  9. The history of cancer [Online]. Available: http://cancerfilms.org/timeline/. Accessed 10 Aug 2018

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Integrated Biophysics and Structural Biology Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial CentreHomi Bhabha National InstituteNavi MumbaiIndia

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