Development of Neuroimaging-Based Biomarkers in Psychiatry

  • Orkun Aydin
  • Pinar Unal Aydin
  • Ayla ArslanEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1192)


This chapter presents an overview of accumulating neuroimaging data with emphasis on translational potential. The subject will be described in the context of three disease states, i.e., schizophrenia, bipolar disorder, and major depressive disorder, and for three clinical goals, i.e., disease risk assessment, subtyping, and treatment decision.


Connectomics Neuroimaging Amygdala Hippocampus Prefrontal cortex White matter Gray matter Functional magnetic resonance imaging Magnetic resonance imaging Positron emission tomography Diffusion tensor imaging Voxel-based morphometry Machine learning Biomarker Schizophrenia Depression Diagnosis Prognosis Predictive Personalized Bipolar disorder 



Alzheimer’s disease


Attention deficit hyperactivity disorder


Anterior cingulate cortex


Bipolar disorder


Blood oxygenation level dependent


Chronic schizophrenia


Computerized tomography


Disability-adjusted life years


Diagnostics and Statistics Manual


Default mode network


Dorsolateral prefrontal cortex


Diffusion tensor imaging


Echo-planar imaging


Fractional anisotropy


Functional connectivity strength


First episode schizophrenia


Functional magnetic resonance imaging


International Classification of Diseases


Mild cognitive impairment


Magnetic resonance imaging


Major depression disorder


Medial prefrontal cortex


Neurocognitive disorder


Obsessive-compulsive disorder


Predictive, preventative, personalized, and participatory


Positron emission tomography


Research domain criteria


Social anxiety disorder




Single-photon emission computed tomography


Voxel-based morphometry


Years lived with disability


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Psychology Program, Faculty of Arts and Social SciencesInternational University of SarajevoSarajevoBosnia and Herzegovina
  2. 2.Genetics and Bioengineering Program, Faculty of Engineering and Natural SciencesInternational University of SarajevoSarajevoBosnia and Herzegovina

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