Myelin pp 123-144 | Cite as

Oligodendrocyte Physiology Modulating Axonal Excitability and Nerve Conduction

  • Yoshihiko YamazakiEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1190)


Oligodendrocytes enable saltatory conduction by forming a myelin sheath around axons, dramatically boosts action potential conduction velocity. In addition to this canonical function of oligodendrocytes, it is now known that oligodendrocytes can respond to neuronal activity and regulate axonal conduction. Importantly, white matter plasticity, including adaptive responses by oligodendrocytes, has been shown to be involved in learning and memory. In this chapter, the role of oligodendrocytes in axonal conduction and axonal excitability will be reviewed. Focus will be paid to the mechanisms through which oligodendrocytes, including perineuronal oligodendrocytes, facilitate and suppress axonal conduction.


Action potential Conduction velocity Hippocampus Myelin 


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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of PhysiologyYamagata University School of MedicineYamagataJapan

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