Myelin pp 257-264 | Cite as

Roads to Formation of Normal Myelin Structure and Pathological Myelin Structure

  • Yoshio BandoEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1190)


Demyelination and axonal damage are responsible for neurological deficits in demyelinating diseases including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. However, the pathology of demyelination and axonal damage in MS is not fully understood. While immunologists have accumulated evidence, which is involved in many immunological events in these diseases, neuroscientists and anatomists have also investigated morphological changes of myelin in these diseases. In this chapter, a new concept of demyelination will be described.


MS EAE Demyelination Oligodendrocyte Myelin Axonal degeneration 


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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Functional Anatomy and NeuroscienceAsahikawa Medical UniversityAsahikawaJapan
  2. 2.Department of AnatomyAkita University Graduate School of MedicineAkitaJapan

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