Empirical Modelling and Optimisation of Bio-Micromachining on Antimicrobial Copper to Fabricate Micromixing System

  • Abhishek Singh
  • Arul Manikandan
  • M. Ravi SankarEmail author
  • K. Pakshirajan
  • L. Roy
Conference paper
Part of the Lecture Notes on Multidisciplinary Industrial Engineering book series (LNMUINEN)


Bio-micromachining is upcoming future unconventional manufacturing  process. It has many benefits over other conventional as well as non-conventional process, some of them are no heat-affected zone, no recast layer, no formation of the white layer, and many others. In the present paper, bio-micromachining on copper has been demonstrated. Fabrication of microchannel, as well as optimisation of the process, is done by using central composite run design (CCRD) in combination with response surface methodology (RSM). ANOVA analysis shows that the machining time is the main influencing parameter followed by inoculum size. The maximum material removal obtained was 0.571 grams, when machining time was 32 h and inoculum size was 7.5% (v/v). It is suggested to use the inoculum age of microorganism after 5 days of culture and best before 12 days, in order to get the maximum amount of material removal.


Bio-micromachining ANOVA Machining time Material removal 


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© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  1. 1.Centre for the Environment, Indian Institute of Technology GuwahatiGuwahatiIndia
  2. 2.Department of Chemical EngineeringIndian Institute of Technology GuwahatiGuwahatiIndia
  3. 3.Department of Mechanical EngineeringIndian Institute of Technology GuwahatiGuwahatiIndia
  4. 4.Department of Bioscience and BioengineeringIndian Institute of Technology GuwahatiGuwahatiIndia
  5. 5.Department of Mechanical EngineeringNational Institute of Technology SilcharSilcharIndia

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