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Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Brain Injury

  • Yazhu Quan
  • Ang Ma
  • Baoxue YangEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1182)

Abstract

Neurological dysfunction and death are common events leading to acute and chronic neurodegenerative diseases. Neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease account for a significant and increasing proportion of morbidity and mortality in the developed world. Ganoderma lucidum (G. lucidum, Lingzhi), one of highly nutritious and significantly effective medicinal herbs, has been used for clinical applications for thousands of years. Several researches have shown that it has a wide range of brain damage protection, such as amelioration of Alzheimer’s disease, therapeutic effect on epilepsy, and the protective effect on neural cells in stroke injury. This chapter reviews the neuroprotective effects of G. lucidum and its extracts on brain injury diseases, including Alzheimer’s disease, Parkinson’s disease, stroke, epilepsy, and other neurodegenerative diseases, and the potential clinical applications.

Keywords

Ganoderma Alzheimer’s disease Parkinson’s disease Stroke Epilepsy 

Notes

Acknowledgments

Research in the authors’ laboratory is supported by National Natural Science Foundation of China grants 81620108029, 81330074, 81261160507, and 81170632, Beijing Natural Science Foundation grant 7172113, Drug Discovery Program grant 2009ZX09301-010-30, the Research Fund for the Doctoral Program of Higher Education 20100001110047, the 111 project, and International Science and Technology Cooperation Program of China 2012DFA11070.

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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical SciencesPeking UniversityBeijingChina
  2. 2.Department of Pharmacology, School of Basic Medical SciencesPeking UniversityBeijingChina

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