Antitumor Effect of Ganoderma (Lingzhi) Mediated by Immunological Mechanism and Its Clinical Application

  • Zhibin LinEmail author
  • Lixin Sun
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1182)


The antitumor effect of Ganoderma (Lingzhi) is closely related to immunoregulation. Based on our research and other references, this article discussed the antitumor effect of Ganoderma mediated by immunological mechanism, including promoting the function of mononuclear-macrophages and natural killers; promoting M1-type macrophage polarization vs M2-type; promoting maturation and differentiation of dendritic cells, increasing its antigen presentation, activating lymphocytes and increasing cytotoxicity of cytotoxin T lymphocyte; promoting production of cytokines; and inhibiting tumor escape from immune surveillance. Also, clinical studies with immunological indexes were reviewed.


Ganoderma Lingzhi Polysaccharides Triterpenes Immune Tumor 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Pharmacology, School of Basic Medical SciencesPeking UniversityBeijingChina
  2. 2.Affiliated Hospital of Chengde Medical UniversityChengdeChina

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