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Tuberculosis as an Underlying Etiological Factor for Other Human Respiratory Diseases

  • Ronan F. O’TooleEmail author
Chapter

Abstract

Tuberculosis (TB) does not occur in isolation from other human illnesses. There are multiple examples where TB combines with one of more comorbidities to amplify its prevalence. Noncommunicable diseases such as diabetes, or lifestyle behaviors including smoking and alcohol misuse, place people at a greater risk of presenting with active TB. But the epidemiological associations between TB and other human conditions are not confined to increasing susceptibility to TB disease. TB, in itself, is an underlying risk factor for the development of downstream respiratory illnesses later in life. This indicates that injury to the host resulted from an episode of TB persists beyond successful eradication of Mycobacterium tuberculosis infection by antimicrobial drug therapy. In this chapter, the specific role of TB in promoting other lung diseases is examined. In particular, TB during childhood increases the risk of development of progressive and poorly reversible airway diseases that include bronchiectasis and chronic obstructive pulmonary disease. It is apparent from the literature that prevention of TB disease offers a potential pathway for reducing the global burden of downstream chronic lung diseases.

Keywords

Tuberculosis Mycobacterium tuberculosis Bronchiectasis Chronic obstructive pulmonary disease 

Abbreviations

AIDS

acquired immunodeficiency syndrome

BOLD

Burden of Obstructive Lung Disease

CI

confidence interval

COPD

chronic obstructive pulmonary disease

FEV1

forced expired volume of air in the first second of expiration

FVC

forced vital capacity

HIV

human immunodeficiency virus

MDR

multidrug resistant

OR

odds ratio

TB

tuberculosis

UI

uncertainty interval

UK

United Kingdom

WHO

World Health Organization

Notes

Funding

Not applicable.

Competing Interests

The author declares that he has no financial or other conflicts of interest.

Ethical Approval

Not required.

References

  1. Amaral AF, Coton S, Kato B, Tan WC, Studnicka M, Janson C, Gislason T, Mannino D, Bateman ED, Buist S, Burney PG, Group BCR (2015) Tuberculosis associates with both airflow obstruction and low lung function: BOLD results. Eur Respir J 46:1104–1112.  https://doi.org/10.1183/13993003.02325-2014CrossRefPubMedPubMedCentralGoogle Scholar
  2. Bates MN, Khalakdina A, Pai M, Chang L, Lessa F, Smith KR (2007) Risk of tuberculosis from exposure to tobacco smoke: a systematic review and meta-analysis. Arch Intern Med 167(4):335–342.  https://doi.org/10.1001/archinte.167.4.335CrossRefGoogle Scholar
  3. Bilton D, Jones AL (2011) Bronchiectasis: epidemiology and causes. Eur Respir Monogr 52:1–10Google Scholar
  4. Byrne AL, Marais BJ, Mitnick CD, Lecca L, Marks GB (2015) Tuberculosis and chronic respiratory disease: a systematic review. Int J Infect Dis 32:138–146.  https://doi.org/10.1016/j.ijid.2014.12.016CrossRefPubMedGoogle Scholar
  5. Cantin L, Bankier AA, Eisenberg RL (2009) Bronchiectasis. AJR Am J Roentgenol 193(3):W158–W171.  https://doi.org/10.2214/AJR.09.3053CrossRefPubMedGoogle Scholar
  6. Chaisson RE, Martinson NA (2008) Tuberculosis in Africa – combating an HIV-driven crisis. N Engl J Med 358(11):1089–1092.  https://doi.org/10.1056/NEJMp0800809CrossRefGoogle Scholar
  7. Collaborators GBDCRD (2017) Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the global burden of disease study 2015. Lancet Respir Med 5(9):691–706.  https://doi.org/10.1016/S2213-2600(17)30293-XCrossRefGoogle Scholar
  8. Dheda K, Booth H, Huggett JF, Johnson MA, Zumla A, Rook GA (2005) Lung remodeling in pulmonary tuberculosis. J Infect Dis 192(7):1201–1209.  https://doi.org/10.1086/444545CrossRefPubMedGoogle Scholar
  9. Di Naso FPJ, Schuh SJ, Unis G (2011) Functional evaluation in patients with pulmonary tuberculosis sequelae. Rev Port Pneumol 17(5):216–221CrossRefGoogle Scholar
  10. Ehrlich RI, Adams S, Baatjies R, Jeebhay MF (2011) Chronic airflow obstruction and respiratory symptoms following tuberculosis: a review of South African studies [review article]. Int J Tuberc Lung Dis 15(7):886–891.  https://doi.org/10.5588/ijtld.10.0526CrossRefPubMedGoogle Scholar
  11. Eisner MD, Anthonisen N, Coultas D, Kuenzli N, Perez-Padilla R, Postma D, Romieu I, Silverman EK, Balmes JR, Committee on Nonsmoking COPD Environmental and Occupational Health Assembly (2010) An official American Thoracic Society public policy statement: novel risk factors and the global burden of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 182(5):693–718.  https://doi.org/10.1164/rccm.200811-1757STCrossRefPubMedGoogle Scholar
  12. Fok A, Numata Y, Schulzer M, FitzGerald MJ (2008) Risk factors for clustering of tuberculosis cases: a systematic review of population-based molecular epidemiology studies. Int J Tuberc Lung Dis 12(5):480–492PubMedGoogle Scholar
  13. Geldmacher C, Schuetz A, Ngwenyama N, Casazza JP, Sanga E, Saathoff E, Boehme C, Geis S, Maboko L, Singh M, Minja F, Meyerhans A, Koup RA, Hoelscher M (2008) Early depletion of Mycobacterium tuberculosis-specific T helper 1 cell responses after HIV-1 infection. J Infect Dis 198(11):1590–1598.  https://doi.org/10.1086/593017CrossRefPubMedPubMedCentralGoogle Scholar
  14. Geldmacher C, Ngwenyama N, Schuetz A, Petrovas C, Reither K, Heeregrave EJ, Casazza JP, Ambrozak DR, Louder M, Ampofo W, Pollakis G, Hill B, Sanga E, Saathoff E, Maboko L, Roederer M, Paxton WA, Hoelscher M, Koup RA (2010) Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection. J Exp Med 207(13):2869–2881.  https://doi.org/10.1084/jem.20100090CrossRefPubMedPubMedCentralGoogle Scholar
  15. Gothi D, Shah DV, Joshi JM (2007) Clinical profile of diseases causing chronic airflow limitation in a tertiary care Centre in India. J Assoc Physicians India 55:551–555PubMedGoogle Scholar
  16. Grancher J (1878) La dilatation des bronches chez les tuberculeux. Gazette Medicale de Paris 146Google Scholar
  17. Hnizdo E, Singh T, Churchyard G (2000) Chronic pulmonary function impairment caused by initial and recurrent pulmonary tuberculosis following treatment. Thorax 55(1):32–38CrossRefGoogle Scholar
  18. Hwang JH, Choe PG, Kim NH, Bang JH, Song KH, Park WB, Kim ES, Park SW, Kim HB, Kim NJ, Oh MD, Choe KW (2013) Incidence and risk factors of tuberculosis in patients with human immunodeficiency virus infection. J Korean Med Sci 28(3):374–377.  https://doi.org/10.3346/jkms.2013.28.3.374CrossRefPubMedPubMedCentralGoogle Scholar
  19. Inghammar M, Ekbom A, Engstrom G, Ljungberg B, Romanus V, Lofdahl CG, Egesten A (2010) COPD and the risk of tuberculosis – a population-based cohort study. PLoS One 5(4):e10138.  https://doi.org/10.1371/journal.pone.0010138CrossRefPubMedPubMedCentralGoogle Scholar
  20. Jeon CY, Murray MB (2008) Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies. PLoS Med 5(7):e152.  https://doi.org/10.1371/journal.pmed.0050152CrossRefPubMedPubMedCentralGoogle Scholar
  21. Jones OR, Cournand A (1933) Shrunken pulmonary lobe with chronic bronchiectasis. Am Rev Tuberc 28:293Google Scholar
  22. Jordan TS, Spencer EM, Davies P (2010) Tuberculosis, bronchiectasis and chronic airflow obstruction. Respirology 15(4):623–628.  https://doi.org/10.1111/j.1440-1843.2010.01749.xCrossRefPubMedGoogle Scholar
  23. Klatsky AL (2009) Alcohol and cardiovascular diseases. Expert Rev Cardiovasc Ther 7(5):499–506.  https://doi.org/10.1586/erc.09.22CrossRefPubMedGoogle Scholar
  24. Laatikainen T, Manninen L, Poikolainen K, Vartiainen E (2003) Increased mortality related to heavy alcohol intake pattern. J Epidemiol Community Health 57(5):379–384CrossRefGoogle Scholar
  25. Lee CH, Lee MC, Shu CC, Lim CS, Wang JY, Lee LN, Chao KM (2013) Risk factors for pulmonary tuberculosis in patients with chronic obstructive airway disease in Taiwan: a nationwide cohort study. BMC Infect Dis 13:194.  https://doi.org/10.1186/1471-2334-13-194CrossRefPubMedPubMedCentralGoogle Scholar
  26. Lin HH, Ezzati M, Murray M (2007) Tobacco smoke, indoor air pollution and tuberculosis: a systematic review and meta-analysis. PLoS Med 4(1):e20.  https://doi.org/10.1371/journal.pmed.0040020CrossRefPubMedPubMedCentralGoogle Scholar
  27. Lokke A, Lange P, Scharling H, Fabricius P, Vestbo J (2006) Developing COPD: a 25 year follow up study of the general population. Thorax 61(11):935–939.  https://doi.org/10.1136/thx.2006.062802CrossRefPubMedPubMedCentralGoogle Scholar
  28. Lonnroth K, Williams BG, Stadlin S, Jaramillo E, Dye C (2008) Alcohol use as a risk factor for tuberculosis – a systematic review. BMC Public Health 8:289.  https://doi.org/10.1186/1471-2458-8-289CrossRefPubMedPubMedCentralGoogle Scholar
  29. Lonnroth K, Roglic G, Harries AD (2014) Improving tuberculosis prevention and care through addressing the global diabetes epidemic: from evidence to policy and practice. Lancet Diabetes Endocrinol 2(9):730–739.  https://doi.org/10.1016/S2213-8587(14)70109-3CrossRefPubMedGoogle Scholar
  30. Lundback B, Lindberg A, Lindstrom M, Ronmark E, Jonsson AC, Jonsson E, Larsson LG, Andersson S, Sandstrom T, Larsson K, Obstructive Lung Disease in Northern Sweden S (2003) Not 15 but 50% of smokers develop COPD? – report from the obstructive lung disease in Northern Sweden studies. Respir Med 97(2):115–122CrossRefGoogle Scholar
  31. Mathers CD, Loncar D (2006) Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 3(11):e442.  https://doi.org/10.1371/journal.pmed.0030442CrossRefPubMedPubMedCentralGoogle Scholar
  32. Mattila T, Heliovaara M, Rissanen H, Knekt P, Puukka P, Vasankari T (2017) Tuberculosis, airway obstruction and mortality in a Finnish population. COPD 14(2):143–149.  https://doi.org/10.1080/15412555.2016.1250253CrossRefPubMedGoogle Scholar
  33. Nag V, Nandan D, Singh S, Arora S, Tsanglao W, Arya N (2015) Pulmonary tuberculosis: a predominant cause of childhood bronchiectasis in India. J Commun Dis 47(1):14–18Google Scholar
  34. O’Donnell AE (2008) Bronchiectasis. Chest 134(4):815–823.  https://doi.org/10.1378/chest.08-0776CrossRefPubMedGoogle Scholar
  35. Pasipanodya JG, McNabb SJ, Hilsenrath P, Bae S, Lykens K, Vecino E, Munguia G, Miller TL, Drewyer G, Weis SE (2010) Pulmonary impairment after tuberculosis and its contribution to TB burden. BMC Public Health 10:259.  https://doi.org/10.1186/1471-2458-10-259CrossRefPubMedPubMedCentralGoogle Scholar
  36. Pasteur MC, Helliwell SM, Houghton SJ, Webb SC, Foweraker JE, Coulden RA, Flower CD, Bilton D, Keogan MT (2000) An investigation into causative factors in patients with bronchiectasis. Am J Respir Crit Care Med 162(4 Pt 1):1277–1284.  https://doi.org/10.1164/ajrccm.162.4.9906120CrossRefPubMedGoogle Scholar
  37. Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS, Committee GS (2001) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) workshop summary. Am J Respir Crit Care Med 163(5):1256–1276.  https://doi.org/10.1164/ajrccm.163.5.2101039CrossRefPubMedGoogle Scholar
  38. Petty TL (2006) The history of COPD. Int J Chron Obstruct Pulmon Dis 1(1):3–14PubMedPubMedCentralGoogle Scholar
  39. Plit ML, Anderson R, Van Rensburg CE, Page-Shipp L, Blott JA, Fresen JL, Feldman C (1998) Influence of antimicrobial chemotherapy on spirometric parameters and pro-inflammatory indices in severe pulmonary tuberculosis. Eur Respir J 12(2):351–356CrossRefGoogle Scholar
  40. Ringshausen FC, de Roux A, Diel R, Hohmann D, Welte T, Rademacher J (2015) Bronchiectasis in Germany: a population-based estimation of disease prevalence. Eur Respir J 46(6):1805–1807.  https://doi.org/10.1183/13993003.00954-2015CrossRefPubMedGoogle Scholar
  41. Sahoo K, Panda BN, Singh VP, Kiran KG, Raha B, Bhalla JS (1988) Bronchographic evaluation of radiologic sequelae of pulmonary tuberculosis after short term chemotherapy. Indian J Tuberc 35(3):128–132Google Scholar
  42. Salvi SS, Barnes PJ (2009) Chronic obstructive pulmonary disease in non-smokers. Lancet 374(9691):733–743.  https://doi.org/10.1016/S0140-6736(09)61303-9. piiCrossRefPubMedGoogle Scholar
  43. Shoemark A, Ozerovitch L, Wilson R (2007) Aetiology in adult patients with bronchiectasis. Respir Med 101(6):1163–1170.  https://doi.org/10.1016/j.rmed.2006.11.008CrossRefPubMedGoogle Scholar
  44. Slama K, Chiang CY, Enarson DA, Hassmiller K, Fanning A, Gupta P, Ray C (2007) Tobacco and tuberculosis: a qualitative systematic review and meta-analysis. Int J Tuberc Lung Dis 11(10):1049–1061PubMedGoogle Scholar
  45. Swaminathan S, Ramachandran R, Baskaran G, Paramasivan CN, Ramanathan U, Venkatesan P, Prabhakar R, Datta M (2000) Risk of development of tuberculosis in HIV-infected patients. Int J Tuberc Lung Dis 4(9):839–844PubMedGoogle Scholar
  46. Valledor T, Navarrete A (1952) Bronchiectasis in childhood and adult pulmonary tuberculosis. Dis Chest 22(1):46–54CrossRefGoogle Scholar
  47. Wallgren A (1935) Pulmonary tuberculosis in childhood. Am J Dis Child 49:1105Google Scholar
  48. Weycker D, Hansen GL, Seifer FD (2017) Prevalence and incidence of noncystic fibrosis bronchiectasis among US adults in 2013. Chron Respir Dis 14:377–384.  https://doi.org/10.1177/1479972317709649CrossRefPubMedPubMedCentralGoogle Scholar
  49. Willcox PA, Ferguson AD (1989) Chronic obstructive airways disease following treated pulmonary tuberculosis. Respir Med 83(3):195–198CrossRefGoogle Scholar
  50. World Health Organization (2014) The top 10 causes of death. Fact Sheet No 310Google Scholar
  51. World Health Organization (2015) Burden of COPDGoogle Scholar
  52. World Health Organization (2017) Global tuberculosis reportGoogle Scholar
  53. Xu J-F, Ji X-B, Li H-P, Lu H-W (2013) Bronchiectasis caused by pulmonary tuberculosis: the clinical presentations and the differences. In: American thoracic society international conference, 2013, vol C58Google Scholar
  54. Yakar HI, Gunen H, Pehlivan E, Aydogan S (2017) The role of tuberculosis in COPD. Int J Chron Obstruct Pulmon Dis 12:323–329.  https://doi.org/10.2147/COPD.S116086CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.School of Molecular Sciences, College of Science, Health and EngineeringLa Trobe UniversityMelbourneAustralia
  2. 2.Department of Clinical Microbiology, School of MedicineTrinity College DublinDublinIreland
  3. 3.School of Medicine, College of Health and MedicineUniversity of TasmaniaHobartAustralia

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