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Role of Heat Shock Protein 90 in Diabetes and Pancreatic Cancer Management

  • Pinninti Santosh SushmaEmail author
  • Saimila Momin
  • Gowru Srivani
Chapter

Abstract

Heat shock protein 90 (Hsp90) plays a key role in the activation of client proteins, which implicate Hsp90 in various biological processes, specifically coordinating regulatory mechanisms in order to control their activity. One of the key regulators responsible for the upregulation of Hsp90 is heat shock factor (HSF1), whose primary role is to bind heat shock elements (HSEs) with Hsp90 promoters. HSF1 functions by interacting with the transcriptional programming of Hsp90 and with integrate biological signals to regulate levels of Hsp90, especially during times of stress. Furthermore, not only are these Hsp90 protein chaperones upregulated but they can also be released from pancreatic beta cells during pro-inflammatory circumstances. Additionally, Hsp90 interferes with survival and metastatic pathways that are associated with pancreatic cancer (PC) progression. Future investigations on protein chaperons that are associated with Hsp90 may lead to the identification of biomarkers for diseases such as diabetes and PCs and potentially lead to therapeutic strategies in management of these chronic diseases.

Keywords

Heat shock proteins Diabetes Pancreatic cancer 

Abbreviations

17-DMAG

17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin

ATP

Adenosine triphosphate

CTA

C-terminal transactivation

DBD

DNA-binding domain

FAK

Focal adhesion kinase

HIF-1a

Hypoxia-induced factor-1α

HSEs

Heat shock elements

HSF

Heat shock factor

Hsp90

Heat shock protein 90

HSR

Heat shock response

IGF-IR

Insulin-like growth factor-1 receptor

IL-6

Interleukin-6

NK cells

Natural killer cells

NTA

N-terminal transactivation

PBMC

Peripheral blood mononuclear cell

PC

Pancreatic cancer

T1D

Type 1 diabetes

VEGF

Vascular endothelial growth factor

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Pinninti Santosh Sushma
    • 1
    Email author
  • Saimila Momin
    • 2
    • 3
  • Gowru Srivani
    • 2
  1. 1.Department of BiotechnologyDr. NTR University of Health SciencesVijayawadaIndia
  2. 2.Department of Bioscience and BiotechnologyBanasthali UniversityVanasthaliIndia
  3. 3.Department of BiologyEmory UniversityAtlantaUSA

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