Genetic Advance in Depressive Disorder

  • Chen ZhangEmail author
  • Han Rong
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1180)


Major depressive disorder (MDD) and bipolar disorder (BPD) are both chronic, severe mood disorder with high misdiagnosis rate, leading to substantial health and economic burdens to patients around the world. There is a high misdiagnosis rate of bipolar depression (BD) just based on symptomology in depressed patients whose previous manic or mixed episodes have not been well recognized. Therefore, it is important for psychiatrists to identify these two major psychiatric disorders. Recently, with the accumulation of clinical sample sizes and the advances of methodology and technology, certain progress in the genetics of major depression and bipolar disorder has been made. This article reviews the candidate genes for MDD and BD, genetic variation loci, chromosome structural variation, new technologies, and new methods.


Major depression Genetic progress Bipolar depression 



Parts of the contents in this chapter were reused from the articles (Maturana et al. 2015; Zant et al. 2011) with permissions.


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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Division of Mood Disorders, Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina
  2. 2.Department of PsychiatryShenzhen Kangning HospitalShenzhenChina

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