Standardized Treatment Strategy for Depressive Disorder

  • Zuowei WangEmail author
  • Xiancang Ma
  • Chunlan Xiao
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1180)


The treatment strategies of depressive disorder include pharmacological treatment, psychotherapy, and physical therapy (electroconvulsive therapy [ECT], transcranial magnetic stimulation [TMS], etc.). The updated CANMAT guidelines recommended the most second-generation antidepressants as first-line treatments for patients with a major depressive disorder (MDD) of moderate or greater severity. Before antidepressant treatment, comprehensive assessment and safety monitoring are necessary. The application of measurement-based care in the diagnosis and treatment of depression would better ensure that enough dosage and response of antidepressant is achieved at each key point, and the final outcome of disease is improved. It is recommended that antidepressant is used with monotherapy in patients with depression. Antidepressants of different types and different mechanisms could be combined to improve the efficacy for patients with treatment-resistant depression (TRD). To prevent the relapse and recurrence of disease, the long-term treatment comprised of acute treatment, consolidation treatment, and maintenance treatment must be considered for all patients.


Depressive disorder Treatment Pharmacology Standardized 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Hongkou District Mental Health CenterShanghaiChina
  2. 2.The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina

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