Systems and Synthetic Biology Approach to Understand the Importance of Host-Pathogen Interaction
In this chapter, we have discussed the basic factors required to understand the systems biology of host-pathology interaction, which can be applied for modeling and simulating the interaction between plant and pathogens and to get an idea about drug discovery and metabolic engineering. Further, we highlight the high-throughput technologies, such as omics technologies (genomics, transcriptomics, proteomics, and metabolomics), which can be used as a tool for identifying molecular mechanisms of the cell and biochemical pathway of the host-pathogen system. Several mathematical models, such as genome-scale metabolic modeling (constrain-based modeling) and interaction-based modeling (e.g., gene regulatory networks and protein-protein-based interactions) have been demonstrated which help in understanding the genotypic-phenotypic relationship of the host-pathogen interactions.
KeywordsSystems biology Host-pathogen interactions Omics technology Metabolic modeling
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