Crucial Gene Identification for Esophageal Squamous Cell Carcinoma Using Differential Expression Analysis

  • Pallabi PatowaryEmail author
  • Dhruba K. BhattacharyyaEmail author
Conference paper
Part of the Communications in Computer and Information Science book series (CCIS, volume 1241)


This paper attempts to identify a set of crucial genes for Esophageal Squamous Cell Carcinoma (ESCC) using Differential Expression analysis supported by gene enrichment analysis. Initially, we identify a subset of up-regulated and down-regulated genes based on adjusted P-value and log fold change value. Then, we construct co-expression network and PPI network on selected genes to investigate the interactions and associations among these genes. Finally, enrichment analysis is performed to filter out the most crucial subset of genes which are also evidenced to be associated with the ESCC. Three genes, namely TNC, COL1A1, and FN1 are found most closely relevant to ESCC.


RNA-seq ESCC Differential expression analysis Topological network Gene enrichment analysis 



The authors are thankful to the Ministry of HRD, Government of India for supporting this work financially under the FAST scheme.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  1. 1.Department of Computer Science and EngineeringTezpur UniversityTezpurIndia

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