Applications of Nanomaterials in Neurological Diseases, Neuronal Differentiation, Neuronal Protection, and Neurotoxicity

  • Amani H. AlhibshiEmail author
  • Widyan A. Alamoudi
  • Rai K. Farooq


The central nervous system (CNS) is one of the most important systems in the human body, and thus, CNS disorders are causing a significant threat to human health. Researchers from around the world are making impressive efforts to come up with therapeutics and solutions to treat neurodegenerative disorders. However, the issue of brain targeting remains an unsolved challenge due to the blood-brain barrier (BBB) existence. Due to the many unique properties of engineered nanomaterials, their use could make it possible to overcome difficulties in the diagnosis and treatment of neurodegenerative disorders, provide promising neuroprotective strategies, and stimulate neuronal differentiation and nerve generation as a therapeutic approach. In contrast, despite the rapid development of the nanomaterials industry and the spread of its applications in the biomedical field, there is lacking evidence regarding their possible adverse health effects, and very little is known about their toxicity. Numerous in vivo and in vitro studies have emerged, providing evidence of neurotoxic effects of various types of nanoparticles (NPs), and therefore the advantages of nanomaterials should be weighed against their potential effects. In this chapter, we focused on the applications of nanomaterials in neurological disorders, neuronal differentiation, neuroprotection, and neurotoxicity.


Nanodiagnostics Neurodegenerative disorders Neurotoxicity Oxidative stress Neuroprotection Drug delivery Blood–brain barrier Neural differentiation Neurite outgrowth Structure scaffold 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Amani H. Alhibshi
    • 1
    Email author
  • Widyan A. Alamoudi
    • 1
  • Rai K. Farooq
    • 1
  1. 1.Department of Neuroscience Research, Institute for Research and Medical Consultations (IRMC)Imam Abdulrahman Bin Faisal UniversityDammamSaudi Arabia

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