Clinical Evaluation of Plasma Decoy Receptor 3 Levels in Silicosis

  • Suni Lee
  • Shoko Yamamoto
  • Hiroaki Hayashi
  • Hidenori Matsuzaki
  • Naoko Kumagai-Takei
  • Tamayo Hatayama
  • Min Yu
  • Kei Yoshitome
  • Masayasu Kusaka
  • Yasumitsu Nishimura
  • Takemi OtsukiEmail author
Part of the Current Topics in Environmental Health and Preventive Medicine book series (CTEHPM)


Silicosis (SIL) is known to complicate various autoimmune diseases such as rheumatoid arthritis and systemic sclerosis (SSc). To investigate the immunological alterations in SIL, plasma decoy receptor 3 (DcR3) levels were measured. Additionally, correlation studies, multiple regression analysis, and factor analysis were performed using various clinical parameters including respiratory and exposure items, and immunological parameters such as cytokine levels and titers of various autoantibodies detected in SIL subjects. Although actual DcR3 values in SIL and SSc subjects were higher than those in HV, since age was the confounding factor, there were no significant differences. However, in terms of the role of DcR3 in SIL, positive correlations were found between DcR3 and TGF-β or soluble IL-2 receptor (sIL-2R). Multiple regression analysis showed a close and positive relation in SIL between DcR3 and G-CSF, and TGF-β and CENP-B antibodies. Finally, factor analysis indicated that DcR3 values were related to ANA and ANCA-antibodies, as well as G-CSF and IL-6. These data suggested that DcR3 could potentially be utilized as a representative marker of immunological dysfunction in SIL. Further studies are required to explore the cellular and molecular roles of DcR3, and to evaluate the clinical efficacy of utilizing DcR3 measurements for the early detection of complicated autoimmune diseases in SIL patients.


Silicosis Autoimmune diseases Systemic sclerosis Decoy receptor 3 



All authors thank Ms. Yoko Yoshida for the organization of patient sample collection and former Professor Dr. Ayako Ueki for her establishment of the research projects. Financial support: This study was supported in part by a KAKENHI grant (25460825) from the Japanese Society for the Promotion of Science, and research grants from the Kawasaki Medical School (27B065, 26B16, 24S6, 23S5), Ryobi-Teien (2012), and the Kawasaki Foundation for Medical Science and Medical Welfare (2012).

Conflicts of Interest

All authors declare no competing interests regarding this study.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Suni Lee
    • 1
  • Shoko Yamamoto
    • 1
  • Hiroaki Hayashi
    • 2
  • Hidenori Matsuzaki
    • 1
    • 3
  • Naoko Kumagai-Takei
    • 1
  • Tamayo Hatayama
    • 1
  • Min Yu
    • 1
    • 4
    • 5
  • Kei Yoshitome
    • 1
  • Masayasu Kusaka
    • 6
  • Yasumitsu Nishimura
    • 1
  • Takemi Otsuki
    • 1
    Email author
  1. 1.Department of Hygiene, Kawasaki Medical SchoolOkayamaJapan
  2. 2.Department of Dermatology, Kawasaki Medical SchoolOkayamaJapan
  3. 3.Department of Life Science, Faculty of Life and Environmental SciencePrefectural University of HiroshimaHiroshimaJapan
  4. 4.Department of Occupational and Environmental Health ScienceSchool of Public Health, Peking UniversityBeijingChina
  5. 5.Department of Occupational Diseases, Zhejiang Academy of Medical SciencesZhejiangChina
  6. 6.Kusaka HospitalOkayamaJapan

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