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Modernization of the Preservative Solution for Red Blood Cells by Magnetite Nanoparticles (ICNB)

  • A. N. BelousovEmail author
  • E. I. Malygon
  • V. V. Yavorskiy
  • E. Yu. Belousova
Conference paper
  • 35 Downloads
Part of the Springer Proceedings in Physics book series (SPPHY, volume 244)

Abstract

This study was devoted to the learning of the use of nanotechnology to correct the functional activity of red blood cells (RBCs) at the storage stages at a positive temperature. It was established that saline NaCl, which had previously been processed by magnetite nanoparticles (ICNB) had a marked membrane-stabilizing effect, inhibits hemolysis and increasing the sedimentation stability of preserved RBCs. The complex analysis of the obtained data allowed to determine the primary mechanisms effect of the saline NaCl, which had previously been processed by ICNB on the preserved RBCs. The proposed method of additive modernization of preserved RBCs was adapted to the production process. The optimisation results were obtained in creating a simple and practical method of additive modernization of preservation solutions that does not violate the compliance requirements, improves the quality, efficiency and safety transfusion of RBCs.

References

  1. 1.
    J.R. Hess, Vox Sang. 91, 13–19 (2006)CrossRefGoogle Scholar
  2. 2.
    C.F. Högman, H.T. Meryman, Transfus. Med. Rev. 13, 275–296 (1999)CrossRefGoogle Scholar
  3. 3.
    J.R. Hess, Transfus Apher Sci. 43, 51–59 (2010)CrossRefGoogle Scholar
  4. 4.
    A.B. Zimrin, J.R. Hess, Vox Sang. 96, 93–103 (2009)CrossRefGoogle Scholar
  5. 5.
    L. Van de Watering, Vox Sang. 100, 36–45 (2011)CrossRefGoogle Scholar
  6. 6.
    D. Wang, J. Sun, S.B. Solomon et al., Transfusion 52(6), 1184–1195 (2012).  https://doi.org/10.1111/j.1537-2995.2011.03466.xCrossRefGoogle Scholar
  7. 7.
    S.A. Glynn, Transfusion 50, 1164–1169 (2010)CrossRefGoogle Scholar
  8. 8.
    G.M. D’Amici, S. Rinalducci, L. Zolla, J. Proteome Res. 6, 3242–3255 (2007)CrossRefGoogle Scholar
  9. 9.
    A. Verhoeven, P. Hilarius, D. Dekkers et al., Vox Sang. 91, 244–251 (2006)CrossRefGoogle Scholar
  10. 10.
    R.L. Sparrow, M.F. Veale, G. Healey, K.A. Payne, Transfusion 47, 966–968 (2007)CrossRefGoogle Scholar
  11. 11.
    G.J. Bosman, E. Lasonder, Y.A. Groenen-Döpp et al., J. Proteomics. 73, 396–402 (2010)CrossRefGoogle Scholar
  12. 12.
    J.R. Hess, Transfusion 52(8), 1827–1835 (2012).  https://doi.org/10.1111/j.1537-2995.2011.03511.xCrossRefGoogle Scholar
  13. 13.
    J.R. Hess, R.L. Sparrow, P.F. van der Meer et al., Transfusion. 49, 2599–2603 (2009)Google Scholar
  14. 14.
    L.J. Dumont, J.P. AuBuchon, Transfusion 48, 1053–1060 (2008)CrossRefGoogle Scholar
  15. 15.
    M.J. McAteer, L.J. Dumont, J. Cancelas et al., Vox Sang. 99, 34–43 (2010)CrossRefGoogle Scholar
  16. 16.
    The use of magnetite nanoparticles in applied medicine. Int. J. Nano Dimension. 2, 1(5), 25–28 (2011)Google Scholar
  17. 17.
    A.N. Belousov, E.Yu. Belousova, The first steps in discovery new mechanisms of cellular regulation in means by nanotechnology preparations in X International Conference New Information Technologies in Medicine and Ecology (Yalta, Gursuf, 2002), pp. 420–425Google Scholar
  18. 18.
    A.N. Belousov, E.Yu. Belousova, Mechanisms cell regulation by nanotechnology preparations (MCS-B), in BioNanotech Conference & Expo 2012. June 18–21 (Santa Clura, CA, USA, 2012)Google Scholar
  19. 19.
    A.N. Belousov Effect of magnet controlled sorbent on parameters of acid-base balance of the blood and the processes of glycolysis in erythrocytes. Pain Anesth. Intensive Care. Kiev. 1, 263–265 (2000)Google Scholar
  20. 20.
    A.N. Belousov, V.P. Nevzorov ultrastructure of cells in the kidneys and lungs of rabbits after administration of magnetite, in International Collection of Scientific Papers IV Scientific and Practical Conference on the Creation and Testing of New Drugs, vol. 4 (Moscow, 1997), pp. 77–87Google Scholar
  21. 21.
    A.N. Belousov, V.P. Nevzorov, Ultrastructure of liver cells after administration of magnetite, in International Collection of Scientific Papers IV Scientific and Practical Conference on the Creation and Testing of New Drugs, vol. 4 (Moscow, 1997), pp. 71–77Google Scholar
  22. 22.
    A.N. Belousov Spectrum of application magnetite nanopaticles in medicine. Nanotech 2 Chapter 3, 154–157 (2009). ISBN: 978-1-4398-1783-4Google Scholar
  23. 23.
    A.N. Belousov Effect on hemolysis and transport ATPase activity of erythrocytes by means nanoparticles of magnetite controlled sorbent (MCS-B). Pain Anesth. Intensive Care. Kiev 1 (ad), pp. 26–28 (2012)Google Scholar
  24. 24.
    A.N. Belousov J. Cell Mol. Biol. 2(1) 2017Google Scholar
  25. 25.
    A.N. Belousov, Application magnetite of nanoparticles (ICNB Preparation) as magnetically-resonant contrasting means during visualization of tumours. Clean Technol. Sustain. Ind. Organ. 10, 379–381 (2013)Google Scholar
  26. 26.
    A.N. Belousov Prospects Med. Biol.. LSMU. V. IY 1, 94–97 (2012)Google Scholar
  27. 27.
    A.N. Belousov, J. Biomed. Eng. Res. 2(3), 147–152 (2014)Google Scholar
  28. 28.
    A.N. Belousov, J. Nanomater. Molec. Nanotechnol. Manuscript number: JNMN-14-25, 17-21 (2014)Google Scholar
  29. 29.
    A.N. Belousov, J. Clean Technol. Sustain. Ind. Org. 10, 379–381 (2013). ISBN: 978-1-4822-5819-6Google Scholar
  30. 30.
    A.N. Belousov, J. Mater. Sci. Eng. A 4(11), 367–372 (2014)Google Scholar
  31. 31.
    A.N. Belousov, J. Cell Mol. Biol. 2(005), 1–5 (2017)Google Scholar
  32. 32.
    E.H. Eylar, M.A. Madoff, O.V. Brody et al., J. Biol. Chem. 237 (1992)Google Scholar
  33. 33.
    G.M.W. Cook, D.H. Heard, G.V.F. Seaman, Nature (Lond.) 191, 44 (1961)ADSCrossRefGoogle Scholar
  34. 34.
    K.-M. Jan, S. Chien, J. Gen. Physiol. 6(і), 638–654 (1973)Google Scholar
  35. 35.
    D. Sakota, R. Sakamoto, N. Yokoyama et al., Artif. Organs. 33(9), 733–739 (2009). https://doi.org/10.1111/j.1525-1594.2009.00898.xGoogle Scholar
  36. 36.
    M.M. Gedde, D.K. Davis, W.H. Huestis, Biophys J. 72(3), 1234–1246 (1997). doi: 10.1016/S0006-3495(97)78770-8)Google Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • A. N. Belousov
    • 1
    • 2
    • 3
    Email author
  • E. I. Malygon
    • 2
    • 3
  • V. V. Yavorskiy
    • 2
    • 3
  • E. Yu. Belousova
    • 1
    • 2
  1. 1.Laboratory of Applied Nanotechnology of BelousovBelousovUkraine
  2. 2.Kharkov Medical Academy of Postgraduate EducationKharkivUkraine
  3. 3.Kharkov Regional Center of Blood ServiceKharkivUkraine

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