Pharmacogenomics of Antitumor Targeted Agent and Immunotherapy

  • Zhaoqian LiuEmail author
  • Chenxue Mao
  • Jiye Yin


Currently, cancer incidence and mortality rapidly increase and have gradually become the leading cause of death in human disease. The main medications used in clinical cancer therapy can be categorized into three types according to the pharmacological mechanism and therapeutic target, including chemotherapeutic agents, molecule-targeted agents, and immunotherapeutic agents. Targeted therapy and immunotherapy are innovative approaches in cancer therapy that has been widely accepted, both of which possess several irreplaceable advantages compared to chemotherapy. The molecule-targeted agents, which are related to higher accurate and lower toxicity, are proposed against the molecular biological targets like tumor cell proliferation, angiogenesis, apoptosis, and tumor invasion. Immunotherapy has dramatically enhanced the prognosis of tumor patients and has greatly improved the treatment for those with advanced disease. Owing to the less toxicity as well as long-term curative effect, the application of immunotherapy continues to expand with multiple new agents approved in the clinical treatment. Several pharmacogenomic biomarkers have been applied to clinical anticancer treatment in effort to strengthen the patients’ treatment benefits and reduce potential side effects. This chapter systematically summarized the significant pharmacogenomic discoveries of some typical tumor therapeutic drugs involved in targeted therapy and immunotherapy.


Cancer Pharmacogenomics Targeted therapy Immunotherapy 


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© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  1. 1.Department of Clinical PharmacologyXiangya Hospital, Central South University, Hunan Key Laboratory of PharmacogeneticsChangshaChina

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