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Design of Advanced Polymeric Hydrogels for Tissue Regenerative Medicine: Oxygen-Controllable Hydrogel Materials

  • Jeon Il Kang
  • Sohee Lee
  • Jeong Ah An
  • Kyung Min ParkEmail author
Chapter
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Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1250)

Abstract

Engineered polymeric hydrogels have been extensively utilized in tissue engineering and regenerative medicine because of their biocompatibility, tunable properties, and structural similarity in their native extracellular microenvironment. The native extracellular matrix (ECM) has been implicated as a crucial factor in the regulation of cellular behaviors and their fate. The emerging trend in the design of hydrogels involves the development of advanced materials to precisely recapitulate the native ECM or to stimulate the surrounding tissues via physical, chemical, or biological stimuli. The ECM presents various parameters such as ECM components, soluble factors, cell-to-cell and cell-to-matrix interactions, physical forces, and physicochemical environments. Among these environmental factors, oxygen is considered as an essential signaling molecule. In particular, abnormal oxygen tension such as a lack of oxygen (defined as hypoxia) and an excess supply of oxygen (defined as hyperoxia) plays a pivotal role during early vascular development, tissue regeneration and repair, and tumor progression and metastasis. In this chapter, we discuss how engineered polymeric hydrogels serve as either an artificial extracellular microenvironment to create engineered tissues or as an acellular matrix to stimulate the native tissues for a wide range of biomedical applications including tissue engineering and regenerative medicine, wound healing, and engineered disease models. Specifically, we focus on emerging technologies to create advanced polymeric hydrogel materials that accurately mimic or stimulate the native ECM.

Keywords

Polymeric hydrogels Oxygen Artificial extracellular matrix Tissue engineering Regenerative medicine 

Notes

Acknowledgement

This work was supported by the Incheon National University International Cooperative Research Grants in 2017.

References

  1. 1.
    Hussey GS, Dziki JL, Badylak SF (2018) Extracellular matrix-based materials for regenerative medicine. Nat Rev Mater 3(7):159–173Google Scholar
  2. 2.
    Geckil H, Xu F, Zhang X et al (2010) Engineering hydrogels as extracellular matrix mimics. Nanomedicine 5(3):469–484PubMedGoogle Scholar
  3. 3.
    Dimatteo R, Darling NJ, Segura T (2018) In situ forming injectable hydrogels for drug delivery and wound repair. Adv Drug Deliv Rev 127:167–184PubMedPubMedCentralGoogle Scholar
  4. 4.
    Nguyen MK, Jeon O, Dang PN et al (2018) RNA interfering molecule delivery from in situ forming biodegradable hydrogels for enhancement of bone formation in rat calvarial bone defects. Acta Biomater 75:105–114PubMedPubMedCentralGoogle Scholar
  5. 5.
    Wang Y-W, Chen L-Y, An F-P et al (2018) A novel polysaccharide gel bead enabled oral enzyme delivery with sustained release in small intestine. Food Hydrocoll 84:68–74Google Scholar
  6. 6.
    Brovold M, Almeida JI, Pla-Palacín I et al (2018) Naturally-derived biomaterials for tissue engineering applications. In: Chun HJ, Park K, Kim CH, Khang G (eds) Novel biomaterials for regenerative medicine, Advances in experimental medicine and biology, vol 1077. Springer, Singapore, pp 421–449Google Scholar
  7. 7.
    Madl CM, Heilshorn SC (2018) Engineering hydrogel microenvironments to recapitulate the stem cell niche. Annu Rev Biomed Eng 20:21–47PubMedGoogle Scholar
  8. 8.
    Park S, Park K (2016) Engineered polymeric hydrogels for 3D tissue models. Polymers 8(1):23PubMedCentralGoogle Scholar
  9. 9.
    Koh MY, Powis G (2012) Passing the baton: the HIF switch. Trends Biochem Sci 37(9):364–372PubMedPubMedCentralGoogle Scholar
  10. 10.
    Kilgannon JH, Jones AE, Shapiro NI et al (2010) Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA 303(21):2165–2171PubMedGoogle Scholar
  11. 11.
    Simon MC, Keith B (2008) The role of oxygen availability in embryonic development and stem cell function. Nat Rev Mol Cell Biol 9(4):285–296PubMedPubMedCentralGoogle Scholar
  12. 12.
    Park KM, Gerecht S (2014) Hypoxia-inducible hydrogels. Nat Commun 5:4075PubMedPubMedCentralGoogle Scholar
  13. 13.
    André-Lévigne D, Modarressi A, Pepper M et al (2017) Reactive oxygen species and NOX enzymes are emerging as key players in cutaneous wound repair. Int J Mol Sci 18(10):1–28Google Scholar
  14. 14.
    Fosen KM, Thom SR (2014) Hyperbaric oxygen, vasculogenic stem cells, and wound healing. Antioxid Redox Signal 21(11):1634–1647PubMedPubMedCentralGoogle Scholar
  15. 15.
    Chowdhury SR, Mh Busra MF, Lokanathan Y et al (2018) Collagen type I: A versatile biomaterial. In: Chun HJ, Park K, Kim CH, Khang G (eds) Novel biomaterials for regenerative medicine, Advances in experimental medicine and biology, vol 1077. Springer, Singapore, pp 389–414Google Scholar
  16. 16.
    Park S, Park KM (2018) Hyperbaric oxygen-generating hydrogels. Biomaterials 182:234–244PubMedGoogle Scholar
  17. 17.
    Hong Y, Zhou F, Hua Y et al (2019) A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds. Nat Commun 10(1):2060PubMedPubMedCentralGoogle Scholar
  18. 18.
    Yang J-A, Yeom J, Hwang BW et al (2014) In situ-forming injectable hydrogels for regenerative medicine. Prog Polym Sci 39(12):1973–1986Google Scholar
  19. 19.
    Kim MS, Lee MH, Kwon BJ et al (2018) Influence of biomimetic materials on cell migration. In: Noh I (ed) Biomimetic medical materials, Advances in experimental medicine and biology, vol 1064. Springer, Singapore, pp 93–107Google Scholar
  20. 20.
    Kuttappan S, Mathew D, Jo JI et al (2018) Dual release of growth factor from nanocomposite fibrous scaffold promotes vascularisation and bone regeneration in rat critical sized calvarial defect. Acta Biomater 78:36–47PubMedGoogle Scholar
  21. 21.
    Wang Z, Wang Z, Lu WW et al (2017) Novel biomaterial strategies for controlled growth factor delivery for biomedical applications. NPG Asia Mater 9(10):e435Google Scholar
  22. 22.
    Castano O, Perez-Amodio S, Navarro-Requena C et al (2018) Instructive microenvironments in skin wound healing: biomaterials as signal releasing platforms. Adv Drug Deliv Rev 129:95–117PubMedGoogle Scholar
  23. 23.
    Gholipourmalekabadi M, Zhao S, Harrison BS et al (2016) Oxygen-generating biomaterials: a new, viable paradigm for tissue engineering? Trends Biotechnol 34(12):1010–1021PubMedGoogle Scholar
  24. 24.
    Semenza GL (2007) Life with oxygen. Science 318(5847):62–64PubMedGoogle Scholar
  25. 25.
    Pugh CW, Ratcliffe PJ (2003) Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 9(6):677–684PubMedGoogle Scholar
  26. 26.
    Sheehy EJ, Buckley CT, Kelly DJ (2012) Oxygen tension regulates the osteogenic, chondrogenic and endochondral phenotype of bone marrow derived mesenchymal stem cells. Biochem Biophys Res Commun 417(1):305–310PubMedGoogle Scholar
  27. 27.
    Paquet J, Deschepper M, Moya A et al (2015) Oxygen tension regulates human mesenchymal stem cell paracrine functions. Stem Cells Transl Med 4(7):809–821PubMedPubMedCentralGoogle Scholar
  28. 28.
    Wang GL, Jiang BH, Rue EA et al (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A 92(12):5510–5514PubMedPubMedCentralGoogle Scholar
  29. 29.
    Semenza GL, Prabhakar NR (2012) The role of hypoxia-inducible factors in oxygen sensing by the carotid body. In: Nurse C, Gonzalez C, Peers C, Prabhakar N (eds) Arterial chemoreception, Advances in experimental medicine and biology, vol 758. Springer, Dordrecht, pp 1–5Google Scholar
  30. 30.
    Huang LE, Arany Z, Livingston DM et al (1996) Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its α subunit. J Biol Chem 271(50):32253–32259PubMedGoogle Scholar
  31. 31.
    Ben-Yosef Y, Lahat N, Shapiro S et al (2002) Regulation of endothelial matrix metalloproteinase-2 by hypoxia/reoxygenation. Circ Res 90(7):784–791PubMedGoogle Scholar
  32. 32.
    Augustin HG, Koh GY, Thurston G et al (2009) Control of vascular morphogenesis and homeostasis through the angiopoietin–tie system. Nat Rev Mol Cell Biol 10(3):165PubMedGoogle Scholar
  33. 33.
    Gassmann M, Fandrey J, Bichet S et al (1996) Oxygen supply and oxygen-dependent gene expression in differentiating embryonic stem cells. Proc Natl Acad Sci U S A 93(7):2867–2872PubMedPubMedCentralGoogle Scholar
  34. 34.
    Kurihara T, Westenskow PD, Friedlander M (2014) Hypoxia-inducible factor (HIF)/vascular endothelial growth factor (VEGF) signaling in the retina. In: Ash J, Grimm C, Hollyfield J, Anderson R, La Vail M, Bowes Rickman C (eds) Retinal degenerative diseases, Advances in experimental medicine and biology, vol 801. Springer, New York, pp 275–281Google Scholar
  35. 35.
    Park KM, Blatchley MR, Gerecht S (2014) The design of dextran-based hypoxia-inducible hydrogels via in situ oxygen-consuming reaction. Macromol Rapid Commun 35(22):1968–1975PubMedPubMedCentralGoogle Scholar
  36. 36.
    Mohyeldin A, Garzón-Muvdi T, Quiñones-Hinojosa A (2010) Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell 7(2):150–161PubMedGoogle Scholar
  37. 37.
    Sathy BN, Daly A, Gonzalez-Fernandez T et al (2019) Hypoxia mimicking hydrogels to regulate the fate of transplanted stem cells. Acta Biomater 88:314–324PubMedGoogle Scholar
  38. 38.
    Wu C, Zhou Y, Fan W et al (2012) Hypoxia-mimicking mesoporous bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering. Biomaterials 33(7):2076–2085PubMedGoogle Scholar
  39. 39.
    Fan W, Crawford R, Xiao Y (2010) Enhancing in vivo vascularized bone formation by cobalt chloride-treated bone marrow stromal cells in a tissue engineered periosteum model. Biomaterials 31(13):3580–3589PubMedGoogle Scholar
  40. 40.
    Park KM, Gerecht S (2014) Harnessing developmental processes for vascular engineering and regeneration. Development 141(14):2760–2769PubMedPubMedCentralGoogle Scholar
  41. 41.
    Quinlan E, Partap S, Azevedo MM et al (2015) Hypoxia-mimicking bioactive glass/collagen glycosaminoglycan composite scaffolds to enhance angiogenesis and bone repair. Biomaterials 52:358–366PubMedGoogle Scholar
  42. 42.
    Yegappan R, Selvaprithiviraj V, Amirthalingam S et al (2019) Injectable angiogenic and osteognic carrageenan nanocomposite hydrogel for bone tissue engineering. Int J Biol Macromol 122:320–328PubMedGoogle Scholar
  43. 43.
    Heddleston J, Li Z, Lathia J et al (2010) Hypoxia inducible factors in cancer stem cells. Br J Cancer 102(5):789–795PubMedPubMedCentralGoogle Scholar
  44. 44.
    Maltepe E, Simon MC (1998) Oxygen, genes, and development: an analysis of the role of hypoxic gene regulation during murine vascular development. J Mol Med 76(6):391–401PubMedGoogle Scholar
  45. 45.
    Semenza GL (2001) Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol Med 7(8):345–350PubMedGoogle Scholar
  46. 46.
    Abramovic Z, Hou H, Julijana K et al (2011) Modulation of tumor hypoxia by topical formulations with vasodilators for enhancing therapy. In: LaManna J, Puchowicz M, Xu K, Harrison D, Bruley D (eds) Oxygen transport to tissue XXXII, Advances in experimental medicine and biology, vol 701. Springer, Boston, pp 75–82Google Scholar
  47. 47.
    Vaupel P, Mayer A (2014) Hypoxia in tumors: pathogenesis-related classification, characterization of hypoxia subtypes, and associated biological and clinical implications. In: Swartz HM, Harrison DK, Bruley DF (eds) Oxygen transport to tissue XXXVI, Advances in experimental medicine and biology, vol 812. Springer, New York, pp 19–24Google Scholar
  48. 48.
    Shen YI, Abaci HE, Krupski Y et al (2014) Hyaluronic acid hydrogel stiffness and oxygen tension affect cancer cell fate and endothelial sprouting. Biomater Sci 2(5):655–665PubMedPubMedCentralGoogle Scholar
  49. 49.
    Gerecht S, Hanjaya-Putra D, Bose V et al (2011) Controlled activation of morphogenesis to generate a functional human microvasculature in a synthetic matrix. J Thromb Haemost 9:953–954Google Scholar
  50. 50.
    Hanjaya-Putra D, Wong KT, Hirotsu K et al (2012) Spatial control of cell-mediated degradation to regulate vasculogenesis and angiogenesis in hyaluronan hydrogels. Biomaterials 33(26):6123–6131PubMedPubMedCentralGoogle Scholar
  51. 51.
    Dickinson LE, Ho CC, Wang GM et al (2010) Functional surfaces for high-resolution analysis of cancer cell interactions on exogenous hyaluronic acid. Biomaterials 31(20):5472–5478PubMedPubMedCentralGoogle Scholar
  52. 52.
    Lewis DM, Park KM, Tang V et al (2016) Intratumoral oxygen gradients mediate sarcoma cell invasion. Proc Natl Acad Sci U S A 113(33):9292–9297PubMedPubMedCentralGoogle Scholar
  53. 53.
    Rodriguez PG, Felix FN, Woodley DT et al (2008) The role of oxygen in wound healing: a review of the literature. Dermatol Surg 34(9):1159–1169PubMedGoogle Scholar
  54. 54.
    Winter GD (1978) Oxygen and epidermal wound healing. In: Silver IA, Erecińska M, Bicher HI (eds) Oxygen transport to tissue — III, Advances in experimental medicine and biology, vol 94. Springer, New York, pp 673–678Google Scholar
  55. 55.
    Lee JB, Shin YM, Kim WS et al (2018) ROS-responsive biomaterial design for medical applications. In: Noh I (ed) Biomimetic medical materials, Advances in experimental medicine and biology, vol 1064. Springer, Singapore, pp 237–251Google Scholar
  56. 56.
    Steiner T, Seiffart A, Schumann J et al (2018) Hyperbaric oxygen therapy in necrotizing soft tissue infections: a retrospective study. In: Thews O, LaManna J, Harrison D (eds) Oxygen transport to tissue XL, Advances in experimental medicine and biology, vol 1072. Springer, Cham, pp 263–267Google Scholar
  57. 57.
    Alemdar N, Leijten J, Camci-Unal G et al (2016) Oxygen-generating photo-cross-linkable hydrogels support cardiac progenitor cell survival by reducing hypoxia-induced necrosis. ACS Biomater Sci Eng 3(9):1964–1971Google Scholar
  58. 58.
    Kang JI, Park KM, Park KD (2019) Oxygen-generating alginate hydrogels as a bioactive acellular matrix for facilitating wound healing. J Ind Eng Chem 69:397–404Google Scholar
  59. 59.
    Newland B, Baeger M, Eigel D et al (2017) Engineering, oxygen-producing gellan gum hydrogels for dual delivery of either oxygen or peroxide with doxorubicin. ACS Biomater Sci Eng 3(5):787–792Google Scholar
  60. 60.
    Shiekh PA, Singh A, Kumar A (2018) Oxygen-releasing antioxidant cryogel scaffolds with sustained oxygen delivery for tissue engineering applications. ACS Appl Mater Interfaces 10(22):18458–18469PubMedGoogle Scholar
  61. 61.
    Kim HY, Kim SY, Lee HY et al (2019) Oxygen-releasing microparticles for cell survival and differentiation ability under hypoxia for effective bone regeneration. Biomacromolecules 20(2):1087–1097PubMedGoogle Scholar
  62. 62.
    Harrison BS, Eberli D, Lee SJ et al (2007) Oxygen producing biomaterials for tissue regeneration. Biomaterials 28(31):4628–4634PubMedGoogle Scholar
  63. 63.
    Abdi SIH, Ng SM, Lim JO (2011) An enzyme-modulated oxygen-producing micro-system for regenerative therapeutics. Int J Pharm 409(1–2):203–205PubMedGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Jeon Il Kang
    • 1
  • Sohee Lee
    • 1
  • Jeong Ah An
    • 1
  • Kyung Min Park
    • 1
    Email author
  1. 1.Department of Bioengineering and Nano-BioengineeringIncheon National UniversityIncheonRepublic of Korea

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