Extracellular Vesicles: The Next Frontier in Regenerative Medicine and Drug Delivery

  • Md. Asadujjaman
  • Dong-Jin Jang
  • Kwan Hyung Cho
  • Seung Rim Hwang
  • Jun-Pil JeeEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1249)


Extracellular vesicles (EVs) are nanosized membrane particles secreted by cells to convey intercellular information. In recent years, EVs have enticed scientists owing to their prevalent distribution, enormous possibility as therapeutic aspirants, and probable roles as disease biomarkers. As natural transporters in the endogenous communication system, they play a role in protein, lipid, miRNA, mRNA, and DNA transport. In this chapter, we recapitulate the roles of EVs in the vast field of regenerative medicine. This summary mainly describes the potential roles of EVs in the regeneration of extensively studied organs or tissues, such as the heart, kidney, lung, liver, skin, and hair. Furthermore, EV can also transport drugs and corroborate their uptake by target cells through endocytosis; therefore, this chapter also highlights the use of EVs in the field of drug delivery.


Drug delivery Endocytosis Extracellular vesicles (EVs) Regenerative medicine Target cells Therapeutic agents 



ALG-2-interacting protein X


Amyloid precursor protein


ADP-ribosylation factor 6


Arrestin domain-containing protein 1-mediated microvesicles


CXC chemokine receptor 4


Glyceraldehyde 3-phosphate dehydrogenase


Heat shock 70 kDa protein


Heparan sulfate proteoglycan


Intercellular adhesion molecule


Lyso-bis-phosphatidyl acid


Lymphocyte function-associated antigen 1


Major histocompatibility complex


Platelet-endothelial cell adhesion molecule


Phospholipase D


Prion protein


RHO-associated protein kinase


T cell receptor


TAR DNA-binding protein 43


Transferrin receptor


Tumor susceptibility gene 101 protein




Vacuolar protein sorting



This work was supported by the Basic Science Research Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2018R1D1A1B07045240).


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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Md. Asadujjaman
    • 1
  • Dong-Jin Jang
    • 2
  • Kwan Hyung Cho
    • 3
  • Seung Rim Hwang
    • 1
  • Jun-Pil Jee
    • 1
    Email author
  1. 1.College of PharmacyChosun UniversityGwangjuRepublic of Korea
  2. 2.Department of Pharmaceutical EngineeringInje UniversityGimhaeRepublic of Korea
  3. 3.Department of Pharmacy, College of PharmacyInje UniversityGimhaeRepublic of Korea

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