Biogenic Synthesis of Metal Nanoparticles by Plants

  • Mousa SolgiEmail author
  • Mina Taghizadeh


Progressing in time proved development in technology that showed the ability of metals of nanoscale to perform specific utilities better than the bulk form of metals. Nanotechnology by means of specific traits of nanoparticles can be an identical valuable knowledge in various industry and science divisions. The noble metals like silver, gold, platinum, palladium, copper, zinc, selenium, titanium, and iron were used in synthesis of particles of nano-size. Chemical, physical, and biological ways have been used toward synthesis of various types of metal nanoparticles. The extensive potential applications of these nanoparticles made the green (biological or biogenic) synthesis by using bacteria, algae, actinomycetes, fungi, and plants. In the plant-based synthesis, several extracts (leaves, bark, stem, shoots, seeds, latex, secondary metabolites, roots, twigs, peel, fruit, seedlings, essential oils, tissue cultures, gum) are used. Therefore, the current review especially focuses on synthesis particularly plant-intermediated biosynthesis of metal nanoparticles and their classification.


Green nanotechnology Green nanoparticles Biogenic nanoparticles Nanoparticles production 


  1. Abolghasemi R, Haghighi M, Solgi M, Mobinikhaledi A (2019) Rapid synthesis of ZnO nanoparticles by waste thyme (Thymus vulgaris L.). Int J Environ Sci Technol 16:6985–6990. Scholar
  2. Ahamed M, Alsalhi MS, Siddiqui MK (2010) Silver nanoparticle applications and human health. Clin Chem Acta 411:1841–1848CrossRefGoogle Scholar
  3. Asmathunisha N, Kathiresan K (2013) A review on biosynthesis of nanoparticles by marine organisms. Colloids Surf B: Bionterfaces 103:283–287CrossRefGoogle Scholar
  4. Baker S, Rakshith D, Kavitha KS, Santosh P, Kavitha HU, Rao Y, Satish S (2013) Plants: emerging as nanofactories towards facile route in synthesis of nanoparticles. Bioimpacts 3:111–117PubMedPubMedCentralGoogle Scholar
  5. Bankar A, Joshi B, Kumar AR, Zinjarde S (2010) Banana peel extract mediated novel rout for the synthesis of silver nanoparticles. Colloids Surf A Physicochem Eng Asp 368:58–63CrossRefGoogle Scholar
  6. Baskar G, Chandhuru J, Sheraz Fahad K, Praveen AS (2013) Mycological synthesis, characterization and antifungal activity of zinc oxide nanoparticles. Asian J Pharm Technol 3:142–146Google Scholar
  7. Binupriya AR, Sathishkumar M, Yun SI (2010) Myco-crystallization of silver ions to nanosized particles by live and dead cell filtrates of Aspergillus oryzae var. viridis and its bactericidal activity toward Staphylococcus aureus KCCM 12256. Ind Eng Chem Res 49:852–858CrossRefGoogle Scholar
  8. Birla SS, Tiwari VV, Gade AK, Ingle AP, Yadav AP, Rai MK (2009) Fabrication of silver nanoparticles by Phoma glomerata and its combined effect against Escherichia coli Pseudomonas aeruginosa and Staphylococcus aureus. Lett Appl Microbiol 48:173–179CrossRefGoogle Scholar
  9. Chandran SP, Chaudhary M, Pasricha R, Ahmad A, Sastry M (2006) Synthesis of gold nanotriangles and silver nanoparticles using Aloe vera plant extract. Biotechnol Prog 22(2):577–583CrossRefGoogle Scholar
  10. Duan H, Wand D, Li Y (2015) Green chemistry for nanoparticle synthesis. Chem Soc Rev 44:5778–5792CrossRefGoogle Scholar
  11. Dubey SP, Lahtineb M, Sillanpaa M (2010) Green synthesis and characterization of silver and gold nanoparticles using leaf extract of Rosa rugosa. Colloids Surf A Physiochem Eng Asp 364:34–41CrossRefGoogle Scholar
  12. Elango G, Roopan SM (2015) Green synthesis, spectroscopic investigation and photocatalytic activity of lead nanoparticles. Spectrochim Acta A Mol Biomol Spectrosc 139:367–373CrossRefGoogle Scholar
  13. El-Kassas HY, El-Sheekh MM (2014) Cytotoxic activity of biosynthesized gold nanoparticles with an extract of the red seaweed Corallina officinalis on the MCF-7 human breast cancer cell line. Asian Pac J Cancer Prev 15:4311–4317CrossRefGoogle Scholar
  14. Haleemkhan AA, Naseem, Vidya Vardhini B (2015) Synthesis of nanoparticles from plant extracts. Int J Mod Chem Appl Sci 2(3):195–203Google Scholar
  15. Hong SJ, Han JI (2006) Synthesis and characterization of indium tin oxide (ITO) nanoparticle using gas evaporation process. J Electroceram 17:821–826CrossRefGoogle Scholar
  16. Hongwang Z, Swihart MT (2007) Synthesis of tellurium dioxide nanoparticles by spray pyrolysis. Chem Mater 19:1290–1301CrossRefGoogle Scholar
  17. Husseiny MI, El-Aziz MA, Badr Y, Mahmoud MA (2007) Biosynthesis of gold nanoparticles using Pseudomonas aeruginosa. Spectrochim Acta A Mol Biomol Spectrosc 67:1003–1006CrossRefGoogle Scholar
  18. Ingle A, Rai M, Gade A, Bawaskar M (2009) Fusarium solani: a novel biological agent for the extracellular synthesis of silver nanoparticles. J Nanopart Res 11:2079–2085CrossRefGoogle Scholar
  19. Iravani S, Korbekandi H, Mirmohammadi SV, Zolfaghari B (2014) Synthesis of silver nanoparticles: chemical, physical and biological methods. Res Pharm Sci 9:385–406PubMedPubMedCentralGoogle Scholar
  20. Jain D, Kumar Daima H, Kachhwaha S, Kothari SL (2009) Synthesis of plant-mediated silver nanoparticles using papaya fruit extract and evaluation of their antimicrobial activities. Dig Nanomater Biostruct 4(3):557–563Google Scholar
  21. Jena J, Pradhan N, Nayak RR, Dash BP, Sukla LB, Panda PK, Mishra BK (2014) Microalga Scenedesmus sp.: a potential low-cost green machine for silver nanoparticle synthesis. J Microbiol Biotechnol 24:522–533CrossRefGoogle Scholar
  22. Jha AK, Prasad K, Prasad K, Kulkarni AR (2009) Plant system: nature’s nanofactory. Colloids Surf B: Biointerfaces 73:219–223CrossRefGoogle Scholar
  23. Jha AK, Prasad K (2011) Green fruit of chili (capsicum annum L.) synthesizes nano silver! Dig J Nanomater Biostruct 6(4):1717–1723Google Scholar
  24. Kalimuthu K, Babu RS, Venkataraman D, Bilal M, Gurunathan S (2008) Biosynthesis of silver nanoparticles by Bacillus licheniformis. Colloids Surf B: Biointerfaces 65:150–153CrossRefGoogle Scholar
  25. Kalishwaralal K, Deepak VS, Pandian RK, Gurunathan S (2009) Biological synthesis of gold nanocubes from Bacillus licheniformis. Bioresour Technol 100:5356–5358CrossRefGoogle Scholar
  26. Kathiresan K, Manivannan S, Nabeel MA, Dhivya B (2009) Studies on silver nanoparticles synthesized by a marine fungus, Penicillium fellutanum isolated from coastal mangrove sediment. Colloids Surf B: Bionterfaces 71:133–137CrossRefGoogle Scholar
  27. Kaushik N, Thakkar MS, Snehit S, Mhatre MS, Rasesh Y, Parikh MS (2010) Biological synthesis of metallic nanoparticles. Nanomedicine 6:257–262CrossRefGoogle Scholar
  28. Khodashenas B, Ghorbani HR (2014) Synthesis of copper nanoparticles: an overview of the various methods. Korean J Chem Eng 31:1105–1109CrossRefGoogle Scholar
  29. Kim JS, Kuk E, Yu KN, Kim JH, Park SJ, Lee HJ (2007) Antimicrobial effects of silver nanoparticles. Nanomedicine 3:95–101CrossRefGoogle Scholar
  30. Kora AJ, Beedu SR, Jayaraman A (2012) Size-controlled green synthesis of silver nanoparticles mediated by gum ghatti (Anogeissus latifolia) and its biological activity. Org Med Chem Lett 2:17CrossRefPubMedPubMedCentralGoogle Scholar
  31. Korbekandi H, Iravani S, Abbass Hashim A (eds) (2015) Silver nanoparticles, nanotechnology and nanomaterials, the delivery of nanoparticles, ISBN 978-953-51-0615-9Google Scholar
  32. Krishnaraj C, Jagan EG, Rajasekar S, Selvakumar P, Kalaichelvan PT, Mohan N (2010) Synthesis of silver nanoparticles using Acalypha indica extracts and its antimicrobial activity against water pathogens. Colloid Surf B: Biointerfaces 76:50–56CrossRefGoogle Scholar
  33. Lombardi AT, Garcia O Jr (1999) An evaluation into the potential of biological processing for the removal of metals from sewage sludges. Crit Rev Microbiol 25:275–288CrossRefGoogle Scholar
  34. Makarov VV, Love AJ, Sinitsyna OV, Makarova SS, Yaminsky IV, Taliansky ME, Kalinina NO (2014) “Green” nanotechnologies: synthesis of metal nanoparticles using plants. Acta Nat 6:35–44CrossRefGoogle Scholar
  35. Malik MA, Wani MY, Hashim MA (2012) Microemulsion method: a novel route to synthesize organic and inorganic nanomaterials: 1st nano update. Arab J Chem 5:397–417CrossRefGoogle Scholar
  36. Mallick K, Witcomb MJ, Scurell MS (2004) Polymer stabilized silver nanoparticles: a photochemical synthesis route. J Mater Sci 39:4459–4463CrossRefGoogle Scholar
  37. Martínez-Rodríguez RA, Vidal-Iglesias FJ, Solla-Gullón J, Cabrera CR, Feliu JM (2014) Synthesis of Pt nanoparticles in water-in-oil microemulsion: effect of HCl on their surface structure. J Am Chem Soc 136:1280–1283CrossRefGoogle Scholar
  38. McWilliams A (2016) The maturing nanotechnology market: products and applications. NAN031G, Global Markets, BBC Research Report. PrabhatGoogle Scholar
  39. Merga G, Wilson R, Lynn G, Milosavljevic B, Meisel D (2007) Redox catalysis on naked silver nanoparticles. J Phys Chem C 111:12220–12226CrossRefGoogle Scholar
  40. Mukherjee P, Ahmad A, Mandal D, Senapati S, Sainkar SR, Khan MI (2001) Fungus mediated synthesis of silver nanoparticles and their immobilization in the mycelia matrix: a novel biological approach to nanoparticle synthesis. Nano Lett 1:515–519CrossRefGoogle Scholar
  41. Mukhopadhay SS (2014) Nanotechnology in agriculture: prospects and constrains. Nanotechnol Sci Appl 7:63–71CrossRefGoogle Scholar
  42. Nair B, Pradeep T (2002) Coalescence of nanoclusters and formation of submicron crystallites assisted by Lactobacillus strains. Cryst Growth Des 2:293–298CrossRefGoogle Scholar
  43. Narayanan KB, Sakthivel N (2010a) Biological synthesis of metal nanoparticles by microbes. Adv Colloid Interf Sci 156:1–13CrossRefGoogle Scholar
  44. Narayanan KB, Sakthivel N (2010b) Phytosynthesis of gold nanoparticles using leaf extract of Coleus amboinicus Lour. Mater Charact 61(11):1232–1238CrossRefGoogle Scholar
  45. Naseem T, Farrukh MA (2015) Antibacterial activity of green synthesis of iron nanoparticles using Lawsonia inermis and Gardenia jasminoides leaves extract. J Chem 2015:1–7. Scholar
  46. Nasrollahzadeh M, Sajadi SM (2015) Green synthesis of copper nano-particles using Ginkgo biloba L. leaf extract and their catalytic activity for the Huisgen [3+2] cycloaddition of azides and alkynes at room temperature. J Colloid Interface Sci 457:141–147CrossRefGoogle Scholar
  47. Nasrollahzadeh M, Sajadib SM, Khalajc M (2014) Green synthesis of copper nanoparticles using aqueous extract of the leaves of Euphorbia esula L and their catalytic activity for ligand-free Ullmann-coupling reaction and reduction of 4-nitrophenol. RSC Adv 4:47313–47318CrossRefGoogle Scholar
  48. Noruzi M (2015) Biosynthesis of gold nanoparticles using plant extracts. Bioprocess Biosyst Eng 38:1–14CrossRefGoogle Scholar
  49. Phadke M, Patel J (2012) Biological synthesis of silver nano particles using Pseudomonas aeruginosa. J Pure Appl Microbiol 66:1917–1924Google Scholar
  50. Philip D, Unni C, Aromal SA, Vidhu VK (2011) Murraya Koenigii leaf-assisted rapid green synthesis of silver and gold nanoparticles. Spectrochim Acta A Mol Biomol Spectrosc 78:899–904CrossRefGoogle Scholar
  51. Poopathi S, De Britto LJ, Praba VL, Mani C, Praveen M (2015) Synthesis of silver nanoparticles from Azadirachta indica–a most effective method for mosquito control. Environ Sci Pollut Res Int 22:2956–2963CrossRefGoogle Scholar
  52. Priyadharshini RI, Prasannaraj G, Geetha N, Venkatachalam P (2014) Microwavemediated extracellular synthesis of metallic silver and zinc oxide nanoparticles using macro-algae (Gracilaria edulis) extracts and its anticancer activity against. Appl Biochem Biotechnol 174(8):2777–2790CrossRefGoogle Scholar
  53. Rai K, Kumar V, Lee SS, Raza N, Kim KH, Ok YS, Tsang DCW (2018) Nanoparticle-plant interaction: implications in energy, environment, and agriculture. Environ Int 119:1–19CrossRefGoogle Scholar
  54. Rajeshkumar S, Malarkodi C, Gnanajobitha G, Paulkumar K, Vanaja M, Kannan C, Annadurai G (2013) Seaweed-mediated synthesis of gold nanoparticles using Turbinaria conoides and its characterization. J Nanostruc Chem 3:44CrossRefGoogle Scholar
  55. Ravindra BK, Rajasab AHA (2013) A comparative study on biosynthesis of silver nanoparticles using four different fungal species. Int J Pharm Pharm Sci 6:372–376Google Scholar
  56. Rivas L, Sanchez-Cortes S, Garcia-Ramos JV, Morcillo G (2001) Growth of silver colloidal particles obtained by citrate reduction to increase the Raman enhancement factor. Langmuir 17:574–577CrossRefGoogle Scholar
  57. Rodríguez-Sánchez L, Blanco MC, Lpez-Quintela MA (2000) Electrochemical synthesis of silver nanoparticles. J Phys Chem B 104(41):9683–9688Google Scholar
  58. Sadeghi B, Rostami A, Momeni SS (2015) Facile green synthesis of silver nano-particles using seed aqueous extract of Pistacia atlantica and its antibacterial activity. Spectrochim Acta A Mol Biomol Spectrosc 134:326–332CrossRefGoogle Scholar
  59. Sangeetha N, Priyenka Devi KS, Saravanan K (2013) Synthesis and characterization of silver nanoparticles using the marine algae Ulva lactuca. Pollut Res 32:135–139Google Scholar
  60. Schrofel A, Kratosova G, Safarik I, Safarikova M, Raska I, Shor LM (2014) Applications of biosynthesized metallic nanoparticles – a review. Acta Biomater 10:4023–4042CrossRefGoogle Scholar
  61. Shaik MR, Khan M, Kuniyil M, Al-Warthan A, Alkhathlan HZ, Siddiqui MRH, Shaik JP, Ahamed A, Mahmood A, Khan M, Adil SF (2018) Plant-extract-assisted green synthesis of silver nanoparticles using Origanum vulgare L. extract and their microbicidal activities. Sustainability 10:913. Scholar
  62. Shankar SS, Ahmad A, Sastry M (2003) Geranium leaf assisted biosynthesis of silver nanoparticles. Biotechnol Prog 19(6):1627–1631CrossRefGoogle Scholar
  63. Shende S, Ingle AP, Gade A, Rai M (2015) Green synthesis of copper nanoparticles by Citrus medica Linn. (Idilimbu) juice and its antimicrobial activity. World J Microbiol Biotechnol 31:865–873CrossRefPubMedPubMedCentralGoogle Scholar
  64. Simeonidis K, Mourdikoudis S, Moulla M, Tsiaoussis I, Martinez-Boubeta C, Angelakeris M, Dendrinou-Samara C, Kalogirou O (2007) Controlled synthesis and phase characterization of Fe-based nanoparticles obtained by thermal decomposition. J Magn Magn Mater 316:1–4CrossRefGoogle Scholar
  65. Singh P, Kim YJ, Yang DC (2015) A strategic approach for rapid synthesis of gold and silver nanoparticles by Panax ginseng leaves. Artif Cells Nanomed Biotechnol 44:1949–1957. Scholar
  66. Singh P, Kim YJ, Zhang D, Yang DC (2016) Biological synthesis of nanoparticles from plants and microorganisms. Trends Biotechnol 34(7):589–599Google Scholar
  67. Solgi M (2012) Application of nanotechnology and “Smart Packaging” in marketing and postharvest of cut flowers. First nanotechnology and its application in agriculture and natural resources conference. May 15–6, Karaj, IranGoogle Scholar
  68. Solgi M (2014) Evaluation of plant-mediated silver nanoparticles synthesis and its application in postharvest physiology of cut flowers. Physiol Mol Biol Plants 20(30):279–285CrossRefPubMedPubMedCentralGoogle Scholar
  69. Solgi M, Taghizadeh M (2012) Silver nanoparticles ecofriendly synthesis by two medicinal plants. Int J Nanomater Biostruct 2(4):60–64Google Scholar
  70. Solgi M, Kafi M, Taghavi TS, Naderi R (2009) Essential oils and silver nanoparticles (SNP) as novel agents to extend vase life of gerbera (Gerbera jamesonii cv. ‘Dune’). Postharvest Biol Technol 53:155–158CrossRefGoogle Scholar
  71. Solgi M, Kafi M, Taghavi TS, Naderi R, Eyre J, Joyce DC (2011) Effects of silver nanoparticles (SNP) on Gerbera jamesonii cut flowers. Int J Postharvest Innov 2(3):274–285CrossRefGoogle Scholar
  72. Starowicz M, Stypuła B, Banas J (2006) Electrochemical synthesis of silver nanoparticles. Electrochem Commun 8:227–230CrossRefGoogle Scholar
  73. Sudha SS, Rajamanickam K, Rengaramanujam J (2013) Microalgae mediated synthesis of silver nanoparticles and their antibacterial activity against pathogenic bacteria. Indian J Exp Biol 51:393–399PubMedGoogle Scholar
  74. Tan Y, Dai Y, Li Y, Zhua D (2003) Preparation of gold platinum, palladium and silver nanoparticles by the reduction of their salts with a weak reductant-potassium bitartrate. J Mater Chem A 13:1069–1075CrossRefGoogle Scholar
  75. Vijayaraghavan K, Ashokkumar T (2017) Plant-mediated biosynthesis of metallic nanoparticles: a review of literature, factors affecting synthesis, characterization techniques and applications. J Environ Chem Eng 5:4866–4883CrossRefGoogle Scholar
  76. Vijayaraghavan K, Balasubramanian R (2015) Is biosorption suitable for decontamination of metal-bearing wastewaters? A critical review on the state-of-the-art of biosorption processes and future directions. J Environ Manag 160:283–296CrossRefGoogle Scholar
  77. Vijayaraghavan K, Yun YS (2008) Bacterial biosorbents and biosorption. Biotechnol Adv 26:266–291CrossRefGoogle Scholar
  78. Yadav A, Kon K, Kratosova G, Duran N, Ingle AP, Rai M (2015) Fungi as an efficient mycosystem for the synthesis of metal nanoparticles: progress and key aspects of research. Biotechnol Lett 37:2099–2120CrossRefGoogle Scholar
  79. Zahir AA, Chauhan IS, Bagavan A, Kamaraj C, Elango G, Shankar J, Arjaria N, Roopan SM, Rahuman AA, Singh N (2015) Green synthesis of silver and titanium dioxide nanoparticles using Euphorbia prostrata extract shows shift from apoptosis to G0/G1 arrest followed by necrotic cell death in Leishmania donovani. Antimicrob Agents Chemother 59:4782–4799CrossRefPubMedPubMedCentralGoogle Scholar
  80. Zhou GJ, Li SH, Zhang YC, Fu YZ (2014) Biosynthesis of CdS nanoparticles in banana peel extract. J Nanosci Nanotechnol 14:4437–4442CrossRefGoogle Scholar

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© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  1. 1.Department of Horticultural Science, Faculty of Agriculture and Natural ResourcesArak UniversityArakIran

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