Nanotechnology and Nutrigenomics

  • P. Janhavi
  • J. Natasha
  • R. Neelam
  • P. V. Ravindra


The rising popularity and attractive applications of nanotechnologies have impacted all areas of research, including science, agriculture, and health care. Nanoparticles are finding great potential as delivery systems to specific targets in living organisms. Recent advances in food science have revealed that food-derived bioactives significantly influence changes in the genome, epigenome, proteome, and metabolome. This concept is termed “nutrigenomics.” The research in nutrigenomics is fast emerging and explored for the prevention or therapy of various lifestyle-associated disorders such as diabetes, cardiovascular diseases, cancer, and others. The major obstacle in achieving the efficacy from the bioactives is their bioavailability in the plasma and/or at the target site following consumption. The advent of various nanotechnology methods have contributed to promising tools such as nanodelivery systems, including nanocapsules, nanospheres, and biogenic nanoparticles that can enhance the bioavailability of bioactive compounds. This chapter focuses on applications of nanotechnologies in nutrigenomics with a particular focus on their applications for prevention or treatment of certain metabolic disorders.


Nanotechnology Nutrigenomics Metabolic disorders Bioactives Nanodelivery 



The authors are thankful to the Director, CSIR-CFTRI, Mysuru, for providing facilities and infrastructure. The corresponding author thanks the Department of Biotechnology and the Science and Engineering Research Board (SERB), Department of Science and Technology, New Delhi, for providing funds in the form of Ramalingaswami fellowship and extramural grant, respectively.


  1. Ahmed J, Mulla MZ, Arfat YA (2016) Thermo-mechanical, structural characterization and antibacterial performance of solvent casted polylactide/cinnamon oil composite films. Food Control 69:196–204CrossRefGoogle Scholar
  2. Aliabadi HM, Lavasanifar A (2006) Polymeric micelles for drug delivery. Expert Opin Drug Deliv 3:139–162CrossRefGoogle Scholar
  3. Bajpai VK et al (2018) Prospects of using nanotechnology for food preservation, safety, and security. J Food Drug Anal 26(4):1201–1214CrossRefGoogle Scholar
  4. Basri M, Kassim MA, Mohamad R, Ariff AB (2013) Optimization and kinetic study on the synthesis of palm oil ester using Lipozyme TL IM. J Mol Catal B Enzym 85:214–219CrossRefGoogle Scholar
  5. Benito AM et al (1998) Carbon nanotubes production by catalytic pyrolysis of benzene. Carbon 36:681–683CrossRefGoogle Scholar
  6. Bhatia S (2016) Nanoparticles types, classification, characterization, fabrication methods and drug delivery applications. In: Natural polymer drug delivery systems. Springer, Cham, pp 33–93CrossRefGoogle Scholar
  7. Binupriya AR et al (2010) Bioreduction of trivalent aurum to nano-crystalline gold particles by active and inactive cells and cell-free extract of Aspergillus oryzae var. viridis. J Hazard Mater 177(1–3):539–545CrossRefGoogle Scholar
  8. Carlos-Reyes A et al (2019) Dietary compounds as epigenetic modulating agents in cancer. Front Genet 10:79CrossRefPubMedPubMedCentralGoogle Scholar
  9. Chandran SP et al (2006) Synthesis of gold nanotriangles and silver nanoparticles using Aloevera plant extract. Biotechnol Prog 22(2):577–583CrossRefGoogle Scholar
  10. Chen H, Weiss J, Shahidi F (2006) Nanotechnology in nutraceutical and functional foods. Food Technol 60(3):30–36Google Scholar
  11. Costa NMB, Rosa COB (2011) Functional foods: bioactive components and physiological effects. 1 Reprint. Rúbio, Rio de JaneiroGoogle Scholar
  12. Cozzolino SMF, Cominetti C (2013) Biochemical and physiological bases of nutrition in different stages of life in health and disease, 1st edn. Monole, São PauloGoogle Scholar
  13. Crespo L et al (2005) Peptide, and amide bond-containing dendrimers. Chem Rev 105(5):1663–1681CrossRefGoogle Scholar
  14. Dalmiel L, Vargas T, Molina AR (2012) Nutritional genomics for the characterization of the effect of bioactive molecules in lipid metabolism and related pathways. Electrophoresis 33(15):2266–2289CrossRefGoogle Scholar
  15. Dameron CT et al (1989) Biosynthesis of cadmium sulphide quantum semiconductor crystallites. Nature 338(6216):596CrossRefGoogle Scholar
  16. Dhaka V, Gulia N, Ahlawat KS, Khatkar BS (2011) Trans fats—sources, health risks and alternative approach - a review. J Food Sci Technol 48(5):534–541CrossRefPubMedPubMedCentralGoogle Scholar
  17. Dhillon VS, Shahid M, Husain SA (2007) Associations of MTHFR DNMT3b 4977 bp deletion in mtDNA and GSTM1 deletion, and aberrant CpG island hypermethylation of GSTM1 in nonobstructive infertility in Indian men. MHR: Basic science of reproductive medicine 13(4):213–222PubMedGoogle Scholar
  18. Đorđević SM et al (2015) Parenteral nanoemulsions as promising carriers for brain delivery of risperidone: design, characterization and in vivo pharmacokinetic evaluation. IJ Pharm 0493(1–2):40–54Google Scholar
  19. Douglas T, Strable E, Willits D, Aitouchen A, Libera M, Young M (2002) Protein engineering of a viral cage for constrained nanomaterials synthesis. Adv Mater 14(6):415–418CrossRefGoogle Scholar
  20. Ezhilarasi PN et al (2013) Nanoencapsulation techniques for food bioactive components: a review. Food Bioprocess Technol 6(3):628–647CrossRefGoogle Scholar
  21. Feng T et al (2017) Liposomal curcumin and its application in cancer. Int J Nanomed 12:6027–6044CrossRefGoogle Scholar
  22. Feynman R (1960) There’s plenty of room at the bottom (reprint from speech given at annual meeting of the American Physical Society). Eng Sci 23:22–36Google Scholar
  23. Francis MF et al (2005) Engineering polysaccharide-based polymeric micelles to enhance permeability of cyclosporin A across Caco-2 cells. Pharm Res 22:209–219CrossRefGoogle Scholar
  24. Gade AK et al (2008) Exploitation of Aspergillus niger for synthesis of silver nanoparticles. J Biobased Mater Bioenergy 2(3):243–247Google Scholar
  25. Gogotsia Y, Libera JA (2000) Hydrothermal synthesis of multiwall carbon nanotubes. J Mater Res 15:2591–2259CrossRefGoogle Scholar
  26. Gokulakrishnan R, Ravikumar S, Raj JA (2012) In vitro antibacterial potential of metal oxide nanoparticles against antibiotic resistant bacterial pathogens. Asian Pac J Trop Dis 2(5):411–413CrossRefGoogle Scholar
  27. Grumezescu (2017) Multifunctional systems for combined delivery, biosensing and diagnostics, 1st edn BookGoogle Scholar
  28. Hawker CJ, Frechet JMJ (1990) Preparation of polymers with controlled molecular architecture: a new convergent approach to dendritic macromolecules. J Am Chem Soc 112:7638–7647CrossRefGoogle Scholar
  29. Hosomi R, Fukunaga K, Arai H, Kanda S, Nishiyama T, Yoshida M (2013) Effect of combination of dietary fish protein and fish oil on lipid metabolism in rats. J Food Sci Technol 50(2):266–274CrossRefGoogle Scholar
  30. Ingale AG, Chaudhari AN (2013) Biogenic synthesis of nanoparticles and potential applications: an eco-friendly approach. J Nanomed Nanotechol 4(165):1–7Google Scholar
  31. Ingle A, Rai M, Gade A, Bawaskar M (2009) Fusarium solani: a novel biological agent for the extracellular synthesis of silver nanoparticles. J Nanopart Res 11(8):2079CrossRefGoogle Scholar
  32. Iravani S (2011) Green synthesis of metal nanoparticles using plants. Green Chem 13(10):2638–2650CrossRefGoogle Scholar
  33. Ju-Nam Y, Lead JR (2008) Manufactured nanoparticles: an overview of their chemistry, interactions and potential environmental implications. Sci Total Environ 400(1–3):396–414CrossRefGoogle Scholar
  34. Khan I, Saeed K, Khan I (2017) Nanoparticles: properties, applications and toxicities. Arab J ChemGoogle Scholar
  35. Klajnert B, Bryszewska M (2001) Dendrimers: properties and applications. Acta Biochim Pol 48(1):199–208CrossRefGoogle Scholar
  36. Kumari A et al (2010) Development of biodegradable nanoparticles for delivery of quercetin. Colloids Surf B Biointerfaces 80(2):184–192CrossRefGoogle Scholar
  37. Laurent S et al (2008) Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. Chem Rev 108(6):2064–2110CrossRefGoogle Scholar
  38. Lee ES, Na K, Bae YH (2003) Polymeric micelle for tumor pH and folate-mediated targeting. J Control Release 9:103–113CrossRefGoogle Scholar
  39. Liu SQ et al (2003) Preparation and characterization of temperature-sensitive poly(N-isopropyl acrylamide)-b-poly(d,l-lactide) microspheres for protein delivery. Biomacromolecules 46:1784–1793CrossRefGoogle Scholar
  40. Ma RZ et al (2000) The morphology changes of carbon nanotubes under laser irradiation. Carbon 38:636–638CrossRefGoogle Scholar
  41. Madaan K et al (2014) Dendrimers in drug delivery and targeting: drug-dendrimer interactions and toxicity issues. J Pharm Bioallied Sci 6(3):139CrossRefPubMedPubMedCentralGoogle Scholar
  42. Mansoori GA (2002) Advances in atomic & molecular nanotechnology, United Nations Tech Monitor; UN-APCTT Tech Monitor, pp 53–59Google Scholar
  43. Mao C (2003) Viral assembly of oriented quantum dot nanowires. Proc Natl Acad Sci 100(12):6946–6951CrossRefGoogle Scholar
  44. Mead MN (2007) Nutrigenomics: the genome–food interface. Environ Health Perspect 115(12):582–589CrossRefGoogle Scholar
  45. Mourato A, Gadanho M, Lino AR, Tenreiro R (2011) Biosynthesis of crystalline silver and gold nanoparticles by extremophilic yeasts. Bioinorg Chem Appl 2011:8CrossRefGoogle Scholar
  46. Mourya VK, Inamdar NN, Choudhari YM (2011) Chitooligosaccharides: synthesis, characterization and applications. Polym Sci Ser A 53(7):583–612CrossRefGoogle Scholar
  47. Nakajima M (2005) Development of nanotechnology and materials for innovative utilization of biological functions. In: Proceedings of the 34th United States and Japan Natural Resources (UJNR) food and agriculture panel, Susono, JapanGoogle Scholar
  48. Nishiyama N, Kataoka K (2006) Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery. Pharmacol Ther 112(3):630–648CrossRefGoogle Scholar
  49. Niu L et al (2013) Folate-conjugated PEG on single-walled carbon nanotubes for targeting delivery of doxorubicin to cancer cells. Macromol Biosci 13(6):735–744CrossRefGoogle Scholar
  50. Parveen K, Banse V, Ledwani L (2016) Green synthesis of nanoparticles: their advantages and disadvantages. AIP Conf Proc 1724:020048CrossRefGoogle Scholar
  51. Patil CD et al (2012) Larvicidal activity of silver nanoparticles synthesized using Plumeria rubra plant latex against Aedes aegypti and Anopheles stephensi. Parasitol Res 110(5):1815–1822CrossRefGoogle Scholar
  52. Poole CP Jr, Owens FJ (2003) Introduction to nanotechnology. Wiley, HobokenGoogle Scholar
  53. Prasad K, Jha AK, Kulkarni AR (2007) Lactobacillus assisted synthesis of titanium nanoparticles. Nanoscale Res Lett 2(5):248CrossRefPubMedPubMedCentralGoogle Scholar
  54. Prasad SSSV, Kumar SSJ, Kumar PU, Qadri SS, Vajreswari A (2010) Dietary fatty acid composition alters 11β-hydroxysteroid dehydrogenase type 1 gene expression in rat retroperitoneal white adipose tissue. Lipids Health Dis 9(111):1–5Google Scholar
  55. Qian D, Wagner GJ, Liu WK (2002) Mechanics of carbon nanotubes. Appl Mech Rev 55:495–433CrossRefGoogle Scholar
  56. Rahman MBA, Huan QY, Tejo BA, Basri M, Salleh AB, Rahman RNZA (2009) Self-assembly formation of palm-based esters nano-emulsion: a molecular dynamics study. Chem Phys Lett 480(4–6):220–224CrossRefGoogle Scholar
  57. Sales NM, Pelegrini PB, Goersch MC (2014) Nutrigenomics: definitions and advances of this new science. J Nutr Metab 2014:202759CrossRefPubMedPubMedCentralGoogle Scholar
  58. Salouti M, Derakhshan FK (2019) Phytosynthesis of nanoscale materials. In: Advances in phytonanotechnology, From synthesis to application. Elsevier, pp 45–121Google Scholar
  59. Seshadri S, Saranya K, Kowshik M (2011) Green synthesis of lead sulfide nanoparticles by the lead resistant marine yeast, Rhodosporidium diobovatum. Biotechnol Prog 27(5):1464–1469CrossRefGoogle Scholar
  60. Shankar SS et al (2004) Biosynthesis of silver and gold nanoparticles from extracts of different parts of the geranium plant. Appl Nano Sci 1:69–77Google Scholar
  61. Sharifi F et al (2019) Generation of liposomes using a supercritical carbon dioxide eductor vacuum system: optimization of process variables. J CO2 Util 29:163–171CrossRefGoogle Scholar
  62. Sharma N (2012) Exploitation of marine bacteria for production of gold nanoparticles. Microb Cell Factories 11(1):86CrossRefGoogle Scholar
  63. Sharma T, Velmurugan N, Patel P, Chon BH, Sangwai JS (2015) Use of oil-in-water Pickering emulsion stabilized by nanoparticles in combination with polymer flood for enhanced oil recovery. Pet Sci Technol 33(17–18):1595–1604CrossRefGoogle Scholar
  64. Shenton W et al (1999) Inorganic–organic nanotube composites from template mineralization of tobacco mosaic virus. Adv Mater 11(3):253–256CrossRefGoogle Scholar
  65. Shyam Mohapatra, et al., (2019) Applications of targeted nano drugs and delivery systems, nanoscience and nanotechnology in drug delivery, Micro and Nano Technologies BookGoogle Scholar
  66. Singh H (2016) Nanotechnology applications in functional foods; opportunities and challenges. Prev Nutr Food Sci 21(1):1–8CrossRefPubMedPubMedCentralGoogle Scholar
  67. Singh K, Jaiswal D (2011) Human male infertility. Reprod Sci 18(5):418–425CrossRefGoogle Scholar
  68. Sinha R et al (2003) Cancer risk and diet in India. J Postgrad Med 49:222–228PubMedGoogle Scholar
  69. Slawson RM et al (1994) Silver resistance in Pseudomonas stutzeri. Biometals 7(1):30–40CrossRefGoogle Scholar
  70. Srinivas PR et al (2010) Nanotechnology research: applications in nutritional sciences. J Nutr 140(1):119–124CrossRefPubMedPubMedCentralGoogle Scholar
  71. Thakkar KN, Mhatre SS, Parikh RY (2010) Biological synthesis of metallic nanoparticles. Nanomedicine 6(2):257–262CrossRefGoogle Scholar
  72. Thompkinson DK, Bhavana V, Kanika P (2014) Dietary approaches for management of cardio-vascular health- a review. J Food Sci Technol 51(10):2318–2330CrossRefGoogle Scholar
  73. Wang Y, Xia Y (2004) Bottom-up and top-down approaches to the synthesis of Monodispersed spherical colloids of low melting-point metals. Nano Lett 4(10):2047–2050CrossRefGoogle Scholar
  74. Zeng H et al (1998) Synthesis of various forms of carbon nanotubes by AC arc discharge. Carbon 36:259–261CrossRefGoogle Scholar

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© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • P. Janhavi
    • 1
  • J. Natasha
    • 1
  • R. Neelam
    • 1
  • P. V. Ravindra
    • 1
  1. 1.Department of BiochemistryCSIR-CFTRIMysuruIndia

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