Mechanisms and Pathways of Metabolic Reprogramming of Colorectal Cancer

  • A. Krishna Chaitanya
  • Seema Kumari
  • Rama Rao Malla
Part of the Diagnostics and Therapeutic Advances in GI Malignancies book series (DTAGIM)


Colorectal cancer is commonly developed solid cancers globally. Metabolic reprogramming is the most vital features of metastatic cancer cells which show high glycolysis due to Warburg effect. Among the various signaling pathway Wnt pathways plays and critical role in metastasis. Lipid, glucose and tryptophan metabolic remodeling contributes in severity of CRC. We have discussed about metabolic pathways and metabolic reprograming of CRC.


Colorectal cancer Glycolysis Metabolic reprogramming Tryptophan Wnt pathways 



Adenomatous polyposis coli


Aromatic hydrocarbon receptor


Carbohydrate antigen


Cancer antigen


CpG Island Methylator Phenotype instability


Chromosomal instability


Colorectal cancer


Epithelial to mesenchymal transition


Fatty acid


High density lipoprotein


Indoleamine 2, 3-dioxygenase 1


Kirsten rat sarcoma viral oncogene homolog


Low density lipoprotein


MutL homolog 1


Microsatellite instability




Pyruvate dehydrogenase kinase 1


Total cholesterol


Transforming growth factor beta




Wingless-related integration site








Nonsteroidal antiinflammatory drugs



The authors are thankful to GITAM (Deemed to be University) for providing necessary support.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • A. Krishna Chaitanya
    • 2
  • Seema Kumari
    • 1
    • 2
  • Rama Rao Malla
    • 1
    • 2
  1. 1.Department of Biochemistry and BioinformaticsGIS, GITAM (Deemed to be University)VisakhapatnamIndia
  2. 2.Cancer Biology Lab, Department of Biochemistry and BioinformaticsGIS, GITAM (Deemed to be University)VisakhapatnamIndia

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