Advertisement

Mechanisms and Pathways of Metabolic Reprogramming of Colorectal Cancer

  • A. Krishna Chaitanya
  • Seema Kumari
  • Rama Rao Malla
Chapter
  • 37 Downloads
Part of the Diagnostics and Therapeutic Advances in GI Malignancies book series (DTAGIM)

Abstract

Colorectal cancer is commonly developed solid cancers globally. Metabolic reprogramming is the most vital features of metastatic cancer cells which show high glycolysis due to Warburg effect. Among the various signaling pathway Wnt pathways plays and critical role in metastasis. Lipid, glucose and tryptophan metabolic remodeling contributes in severity of CRC. We have discussed about metabolic pathways and metabolic reprograming of CRC.

Keywords

Colorectal cancer Glycolysis Metabolic reprogramming Tryptophan Wnt pathways 

Abbreviations

APC

Adenomatous polyposis coli

ARH

Aromatic hydrocarbon receptor

CA

Carbohydrate antigen

CEA

Cancer antigen

CIMP

CpG Island Methylator Phenotype instability

CIN

Chromosomal instability

CRC

Colorectal cancer

EMT

Epithelial to mesenchymal transition

FA

Fatty acid

HDL

High density lipoprotein

IDO1

Indoleamine 2, 3-dioxygenase 1

KRAS

Kirsten rat sarcoma viral oncogene homolog

LDL

Low density lipoprotein

MLH1

MutL homolog 1

MSI

Microsatellite instability

PC

Phosphatidylcholine

PDK1

Pyruvate dehydrogenase kinase 1

TC

Total cholesterol

TGF-β

Transforming growth factor beta

TGs

Triacylglycerols

Wnt

Wingless-related integration site

5HT

5-hydroxytryptamine

KYNA

Kynurenine

COX

Cyclooxygenase

NSAID

Nonsteroidal antiinflammatory drugs

Notes

Acknowledgement

The authors are thankful to GITAM (Deemed to be University) for providing necessary support.

References

  1. Agudelo LZ, Ferreira DMS, Cervenka I, Bryzgalova G, Dadvar S, Jannig PR, Pettersson-Klein AT, Lakshmikanth T, Sustarsic EG, Porsmyr-Palmertz M, Correia JC, Izadi M, Martínez-Redondo V, Ueland PM, Midttun Ø, Gerhart-Hines Z, Brodin P, Pereira T, Berggren PO, Ruas JL (2018) Kynurenic acid and Gpr35 regulate adipose tissue energy homeostasis and inflammation. Cell Metab.  https://doi.org/10.1016/j.cmet.2018.01.004
  2. American Cancer Society (2017) Cancer facts and figures 2017. Genes Dev.  https://doi.org/10.1101/gad.1593107
  3. Badana A, Chintala M, Varikuti G, Pudi N, Kumari S, Kappala VR, Malla RR (2016) A lipid raft integrity is required for survival of triple negative breast cancer cells. J Breast Cancer 19:372–384CrossRefGoogle Scholar
  4. Bakopoulou A, Leyhausen G, Volk J, Papachristou E, Koidis P, Geurtsen W (2015) Wnt/β-catenin signaling regulates dental pulp stem cells’ responses to pulp injury by resinous monomers. Dent Mater.  https://doi.org/10.1016/j.dental.2015.02.004
  5. Ballor DL, Harvey-Berino JR, Ades PA, Cryan J, Calles-Escandon J (1996) Contrasting effects of resistance and aerobic training on body composition and metabolism after diet-induced weight loss. Metabolism.  https://doi.org/10.1016/S0026-0495(96)90050-5
  6. Belcheva A, Irrazabal T, Robertson SJ, Streutker C, Maughan H, Rubino S, Moriyama EH, Copeland JK, Kumar S, Green B, Geddes K, Pezo RC, Navarre WW, Milosevic M, Wilson BC, Girardin SE, Wolever TMS, Edelmann W, Guttman DS, Philpott DJ, Martin A (2014) Gut microbial metabolism drives transformation of msh2-deficient colon epithelial cells. Cell.  https://doi.org/10.1016/j.cell.2014.04.051
  7. Bevara GB, Kumar ADN, Koteswramma K, Badana AK, Kumari S, Yarla NS, Malla RR (2017) C-glycosyl flavone from Urginea indica inhibits growth and dissemination of Ehrlich ascites carcinoma cells in mice. Anti Cancer Agents Med Chem 17.  https://doi.org/10.2174/1871520617666170103101844
  8. Borges-Canha M, Portela-Cidade JP, Dinis-Ribeiro M, Leite-Moreira AF, Pimentel-Nunes P (2015) Role of colonic microbiota in colorectal carcinogenesis: a systematic review. Rev Esp Enferm Dig 107(10):659–671Google Scholar
  9. Brown RC, Cox CM, Goulding A (2000) High-carbohydrate versus high-fat diets: effect on body composition in trained cyclists. Med Sci Sports Exerc.  https://doi.org/10.1097/00005768-200003000-00021
  10. Deye N, Vincent F, Michel P, Ehrmann S, Da Silva D, Piagnerelli M et al (2016) Changes in cardiac arrest patientsâ€TM temperature management after the 2013 trial: results from an international survey. Annals of intensive, 61–66. Med Hypotheses 97:411–415.  https://doi.org/10.1016/j.clae.2016.08.001 CrossRefGoogle Scholar
  11. Gagnière J, Raisch J, Veziant J, Barnich N, Bonnet R, Buc E, Bringer MA, Pezet D, Bonnet M (2016) Gut microbiota imbalance and colorectal cancer. World J Gastroenterol.  https://doi.org/10.3748/wjg.v22.i2.501
  12. Gnagnarella P, Gandini S, La Vecchia C, Maisonneuve P (2008) Glycemic index, glycemic load, and cancer risk: a meta-analysis. Am J Clin Nutr 87(6):1793–1801Google Scholar
  13. Helms ER, Zinn C, Rowlands DS, Brown SR (2014) A systematic review of dietary protein during caloric restriction in resistance trained lean athletes: a case for higher intakes. Int J Sport Nutr Exerc Metab.  https://doi.org/10.1123/ijsnem.2013-0054
  14. Hunter DJ, Bardet C, Mouraret S, Liu B, Singh G, Sadoine J, Dhamdhere G, Smith A, Tran XV, Joy A, Rooker S, Suzuki S, Vuorinen A, Miettinen S, Chaussain C, Helms JA (2015) Wnt acts as a Prosurvival signal to enhance dentin regeneration. J Bone Miner Res.  https://doi.org/10.1002/jbmr.2444
  15. Irrazábal T, Belcheva A, Girardin SE, Martin A, Philpott DJ (2014) The multifaceted role of the intestinal microbiota in colon cancer. Mol Cell.  https://doi.org/10.1016/j.molcel.2014.03.039
  16. Jansson A, Lindberg JE (2012) A forage-only diet alters the metabolic response of horses in training. Animal.  https://doi.org/10.1017/S1751731112000948
  17. Klement RJ, Kämmerer U (2013) Is there a role for carbohydrate restriction in the treatment and prevention of cancer? Clin Nutr Interface Between Metab Diet Dis.  https://doi.org/10.1201/b16308
  18. Koteswari LL, Kumari S, Kumar AB, Malla RR (2018) A comparative anticancer study on procyanidin C1 against receptor positive and receptor negative breast cancer. Nat Prod Res.  https://doi.org/10.1080/14786419.2018.1557173
  19. Kumari S, Malla R (2015) New insight on the role of plasminogen receptor in Cancer progression. Cancer Growth Metastasis 88:35–42.  https://doi.org/10.4137/CGM.s27335 CrossRefGoogle Scholar
  20. Kumari S, Kaladhar DSVGK, Sandeep Solmon K, Malla RR, Kishore G (2013) Anti-proliferative and metastatic protease inhibitory activities of protoberberines: an in silico and in vitro approaches. Process Biochem 48:1565–1571.  https://doi.org/10.1016/j.procbio.2013.06.027 CrossRefGoogle Scholar
  21. Kumari S, Gayatri DV, Badana A, Dasari VR, Rao Malla R (2015) CD151—a striking marker for Cancer therapy, biomark. Cancer:7–7.  https://doi.org/10.4137/BiC.s21847
  22. Kumari S, Badana AK, Mohan GM, Shailender Naik G, Malla RR (2017) Synergistic effects of coralyne and paclitaxel on cell migration and proliferation of breast cancer cells lines. Biomed Pharmacother.  https://doi.org/10.1016/j.biopha.2017.04.027
  23. Lamas B, Richard ML, Leducq V, Pham HP, Michel ML, Da Costa G, Bridonneau C, Jegou S, Hoffmann TW, Natividad JM, Brot L, Taleb S, Couturier-Maillard A, Nion-Larmurier I, Merabtene F, Seksik P, Bourrier A, Cosnes J, Ryffel B, Beaugerie L, Launay JM, Langella P, Xavier RJ, Sokol H (2016) CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands. Nat Med.  https://doi.org/10.1038/nm.4102
  24. Lamas B, Richard ML, Sokol H (2017) Caspase recruitment domain 9, microbiota, and tryptophan metabolism: dangerous liaisons in inflammatory bowel diseases. Curr Opin Clin Nutr Metab Care.  https://doi.org/10.1097/MCO.0000000000000382
  25. Liu L, Ling J, Wei X, Wu L, Xiao Y (2009) Stem cell regulatory gene expression in human adult dental pulp and periodontal ligament cells undergoing Odontogenic/Osteogenic differentiation. J Endod.  https://doi.org/10.1016/j.joen.2009.07.005
  26. Malla RR, Kumari S, Gavara MM, Badana AK, Gugalavath S, Kumar DKG, Rokkam P (2019) A perspective on the diagnostics, prognostics, and therapeutics of microRNAs of triple-negative breast cancer. Biophys Rev.  https://doi.org/10.1007/s12551-019-00503-8
  27. Marsland BJ (2016) Regulating inflammation with microbial metabolites. Nat Med.  https://doi.org/10.1038/nm.4117
  28. O’Keefe SJD (2016) Diet, microorganisms and their metabolites, and colon cancer. Nat Rev Gastroenterol Hepatol.  https://doi.org/10.1038/nrgastro.2016.165
  29. Ou J, Carbonero F, Zoetendal EG, DeLany JP, Wang M, Newton K, Gaskins HR, O’Keefe SJD (2013) Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans. Am J Clin Nutr.  https://doi.org/10.3945/ajcn.112.056689
  30. Pate KT, Stringari C, Sprowl-Tanio S, Wang K, TeSlaa T, Hoverter NP, McQuade MM, Garner C, Digman MA, Teitell MA, Edwards RA, Gratton E, Waterman ML (2014) Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer. EMBO J.  https://doi.org/10.15252/embj.201488598
  31. Rampal S, Yang MH, Sung J, Son HJ, Choi YH, Lee JH, Kim YH, Chang DK, Rhee PL, Rhee JC, Guallar E, Cho J (2014) Association between markers of glucose metabolism and risk of colorectal adenoma. Gastroenterology.  https://doi.org/10.1053/j.gastro.2014.03.006
  32. Ridler C (2016) IBD: Dysbiosis underlies CARD9 risk alleles in colitis. Nat Rev Gastroenterol Hepatol.  https://doi.org/10.1038/nrgastro.2016.82
  33. Rowland I (2009) The role of the gastrointestinal microbiota in colorectal Cancer. Curr Pharm Des.  https://doi.org/10.2174/138161209788168191
  34. Satoh K, Yachida S, Sugimoto M, Oshima M, Nakagawa T, Akamoto S, Tabata S, Saitoh K, Kato K, Sato S, Igarashi K, Aizawa Y, Kajino-Sakamoto R, Kojima Y, Fujishita T, Enomoto A, Hirayama A, Ishikawa T, Taketo MM, Kushida Y, Haba R, Okano K, Tomita M, Suzuki Y, Fukuda S, Aoki M, Soga T (2017) Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC. Proc Natl Acad Sci.  https://doi.org/10.1073/pnas.1710366114
  35. Saydah SH, Platz EA, Rifai N, Pollak MN, Brancati FL, Helzlsouer KJ (2003) Association of markers of insulin and glucose control with subsequent colorectal cancer risk. Cancer Epidemiol Biomark Prev 12(5):412–418Google Scholar
  36. Sears CL, Garrett WS (2014) Microbes, microbiota, and colon cancer. Cell Host Microbe.  https://doi.org/10.1016/j.chom.2014.02.007
  37. Seema Kumari PN, Anil Badana V, Gayatridevi MV, Malla RR (2016) Coralyne targets proteases involved in cancer progression: an in silico study. In: Computational intelligence techniques in health care. Springer, Singapore, pp 19–30CrossRefGoogle Scholar
  38. Simi B, Sempore B, Mayet MH, Favier RJ (2017) Additive effects of training and high-fat diet on energy metabolism during exercise. J Appl Physiol.  https://doi.org/10.1152/jappl.1991.71.1.197
  39. Singh N, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H, Thangaraju M, Prasad PD, Manicassamy S, Munn DH, Lee JR, Offermanns S, Ganapathy V (2014) Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity.  https://doi.org/10.1016/j.immuni.2013.12.007
  40. Turner ND, Ritchie LE, Bresalier RS, Chapkin RS (2013) The microbiome and colorectal neoplasia: environmental modifiers of dysbiosis. Curr Gastroenterol Rep.  https://doi.org/10.1007/s11894-013-0346-0
  41. Yin X, Li J, Salmon B, Huang L, Lim WH, Liu B, Hunter DJ, Ransom RC, Singh G, Gillette M, Zou S, Helms JA (2015) Wnt signaling and its contribution to craniofacial tissue homeostasis. J Dent Res.  https://doi.org/10.1177/0022034515599772
  42. Zajac A, Poprzecki S, Maszczyk A, Czuba M, Michalczyk M, Zydek G (2014) The effects of a ketogenic diet on exercise metabolism and physical performance in off-road cyclists. Nutrients.  https://doi.org/10.3390/nu6072493
  43. Zhang J, Lu X, Feng G, Gu Z, Sun Y, Bao G, Xu G, Lu Y, Chen J, Xu L, Feng X, Cui Z (2016) Chitosan scaffolds induce human dental pulp stem cells to neural differentiation: potential roles for spinal cord injury therapy. Cell Tissue Res.  https://doi.org/10.1007/s00441-016-2402-1
  44. Zheng W, Li X, Liu D, Li J, Yang S, Gao Z, Wang Z, Yokota H, Zhang P (2018) Mechanical loading mitigates osteoarthritis symptoms by regulating endoplasmic reticulum stress and autophagy. FASEB J.  https://doi.org/10.1096/fj.201801851r

Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • A. Krishna Chaitanya
    • 2
  • Seema Kumari
    • 1
    • 2
  • Rama Rao Malla
    • 1
    • 2
  1. 1.Department of Biochemistry and BioinformaticsGIS, GITAM (Deemed to be University)VisakhapatnamIndia
  2. 2.Cancer Biology Lab, Department of Biochemistry and BioinformaticsGIS, GITAM (Deemed to be University)VisakhapatnamIndia

Personalised recommendations