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Adiponectin Signaling in Colorectal Cancer

  • Gowru Srivani
  • Begum Dariya
  • Ganji Purnachandra Nagaraju
  • Afroz Alam
Chapter
  • 29 Downloads
Part of the Diagnostics and Therapeutic Advances in GI Malignancies book series (DTAGIM)

Abstract

Colorectal cancer (CRC) is an obesity-correlated malignancy. Obesity leads to dysregulation of adipocytokines. The adiponectin is an adipokine, secreted by adipose tissue, plays an essential role in energy metabolism, anti-inflammatory and insulin sensitizing properties. Besides this it also possess anti-neoplastic properties including promotion of apoptosis and inhibition of differentiation and progression of tumor cells. Adiponectin in serum/plasma level always depend on physical activity, diet and inheritance. High concentration of adiponectin are observed to play a crucial role in inhibiting tumor growth, which is also evidenced from the EPIC study where lower adiponectin circulation are at higher risk of cancer including CRC. Thus these results suggest an epidemiological link existing between obesity and cancer in association with adiponectin, playing its crucial role. Even though there are several studies reported in regard of CRC, the results with anti-cancerous property of adiponectin are still inconsistent. Adiponectin has numerous systemic effects that regulates homeostasis and constantly exists in high concentration. However, from the epidemological studies it was reported that low concentration of adiponectin are always at higher risk for CRC. The present article includes molecular evidence with a prominence on the regulation of adiponectin signalling pathways and their crosstalk with other signalling pathways in relation to CRC progression and provides several therapeutic future perspectives for the crucial role of adiponectin, aiming it as a target for the prevention of CRC.

Keywords

CRC Adiponectin Obesity Inflammation Signalling pathways 

Abbreviations

5-FU

Fluorouracil

Acrp30

Adipocyte complement related protein 30

ADP 355

Adenosine di phosphate

Akt

Protein kinase B

AMPK

Adenosine monophosphate Activated protein-kinase

BMI

Body mass index

CRC

Colorectal cancer

DFS

Disease free survival

EGFR

Epidermal growth factor receptor

EPIC

European prospective investigation into cancer and nutrition study

ERK

Extracellular signal—regulated kinase

FAS

Fatty acid synthase

GBP28

Gelatin binding protein

IGF-1

Insulin—like growth factor

IGFBP-1

Insulin like growth factor binding protein-1

IL

Interleukin

mTOR

Mammalian target of rapamycin

NF-κB

Nuclear factor kappa B cells

OS

Overall survival

PCI-1

Plasminogen activator inhibitor-1

PI3K

Phosphadidylinositol-3-kinase

PPARγ

Peroxisome proliferator activated receptor γ

SIRT1

Sirtulin (Silent mating type information regulation 2 homolog) 1

STAT3

Signal transducer and activator of transcription

TNF-α

Tumour necrosis factor

VEGF

Vascular endothelial growth factor

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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Gowru Srivani
    • 1
  • Begum Dariya
    • 1
  • Ganji Purnachandra Nagaraju
    • 2
  • Afroz Alam
    • 1
  1. 1.Department of Bioscience and BiotechnologyBanasthali UniversityVanasthaliIndia
  2. 2.Department of Hematology and Medical Oncology, Winship Cancer InstituteEmory UniversityAtlantaUSA

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