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Alterations in Metabolite-Driven Gene Regulation in Cancer Metabolism

  • Saurabh Kumar JhaEmail author
  • Rahul Yadav
  • Kumari Swati
  • Niraj Kumar Jha
  • Ankur Sharma
  • Fahad Khan
  • Neeraj Kumar
  • Parma Nand
  • Prabhjot Kaur
  • Tanaya Gover
  • Geetika Rawat
Chapter
  • 38 Downloads

Abstract

Cancer is the leading cause of mortality among humans globally. Knowing about the etiology underlying the advancement of cancer is imperative for curtailing the monetary and social burden of cancer. In addition to genetic mutations, altered metabolism involved metabolic rewiring is needed in cancer cells to support their high nutritional demand needed for energy generation. Cancer metabolism also refers to the perturbations in biochemical pathways that are reported in tumor cells compared with most of the normal cells. Metabolic impairments in tumor cells are more frequent which include aerobic glycolysis, decreased oxidative phosphorylation, and the accelerated production of biosynthetic intermediates crucial to the proliferative cells for their growth and development. Interruptions in metabolic cascades responsible for fueling energy into the cancer cells for their growth has been observed in most of the cancer forms. These interruptions, in turn, facilitates growth in tumor cells by ceasing biochemical signals used to inhibit tumor initiation, hence eventually increase the metastatic character of the tumor cells. However, the precise mechanisms whereby metabolic pathways contribute to the cancer prognosis remain uncertain. This chapter thus consolidates recent findings regarding cross talk between metabolic alterations and cancer biology. Further, a concrete and deep understanding of this heterogeneity may enable the advancement and optimization of potential therapeutic approaches that target biochemical pathways associated with proliferation of malignant cells.

Keywords

Cancer Metabolism Metabolites Glycolysis TCA cycle Oncogenes Therapeutics 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Saurabh Kumar Jha
    • 1
    Email author
  • Rahul Yadav
    • 2
  • Kumari Swati
    • 1
  • Niraj Kumar Jha
    • 1
  • Ankur Sharma
    • 2
  • Fahad Khan
    • 3
  • Neeraj Kumar
    • 4
  • Parma Nand
    • 1
  • Prabhjot Kaur
    • 2
  • Tanaya Gover
    • 2
  • Geetika Rawat
    • 2
  1. 1.Department of Biotechnology, School of Engineering & TechnologySharda UniversityGreater NoidaIndia
  2. 2.Department of Life Science, School of Basic Science and Research (SBSR)Sharda UniversityGreater NoidaIndia
  3. 3.Department of BiotechnologyNoida Institute of Engineering & Technology (NIET)Greater NoidaIndia
  4. 4.Department of ChemistrySRM UniversityModi NagarIndia

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