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New Paradigms in the Treatment of Skin Infections: Lipid Nanocarriers to the Rescue

  • Karan Razdan
  • V. R. Sinha
  • Kamalinder K. SinghEmail author
Chapter
  • 22 Downloads

Abstract

Lipid nanocarriers can be an effective drug delivery system for the treatment of skin infections by overcoming the pitfalls associated with conventional topical formulations and offer various advantages such as improved skin permeability, targeted delivery, minimal side effects, increased solubility and bioavailability. The major hurdle in current scenario is antimicrobial resistance which has led to treatment failure and high mortality. Lipid nanocarriers, in this context can be instrumental in the successful eradication of drug-resistant strains in the skin by fusing with cell membrane of infectious microbes and providing an intimate contact and delivering the anti-infective agent directly to the target site. Various lipid-based carriers include liposomes, transferosomes, ethosomes, solid lipid nanoparticles, nanostructured lipid carriers, microemulsion and nanoemulsion. This book chapter summarizes in brief the skin structure and various type of skin infections and then comprehensively describes various lipid nanocarriers and their application in the treatment of cutaneous infections.

Notes

Acknowledgement

The author, Karan Razdan, acknowledges the Department of Science and Technology, New Delhi, India, for their financial assistance as DST INSPIRE JRF (IF170172) and is grateful to Commonwealth Scholarship Commission, UK for their support for carrying out the research work at University of Central Lancashire, UK.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Karan Razdan
    • 1
    • 2
  • V. R. Sinha
    • 2
  • Kamalinder K. Singh
    • 1
    Email author
  1. 1.School of Pharmacy and Biomedical Sciences, Faculty of Clinical and Biomedical SciencesUniversity of Central LancashirePrestonUK
  2. 2.Pharmaceutics DivisionUniversity Institute of Pharmaceutical Sciences, UGC-Centre of Advanced Study, Panjab UniversityChandigarhIndia

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