The Role of Diverse Nanoparticles in Oxidative Stress: In Vitro and In Vivo Studies

  • Shanmugam Rajeshkumar
  • Durairaj Sekar
  • Devaraj Ezhilarasan
  • Thangavelu Lakshmi


Nanoparticles are a very advanced area of nanotechnology and play an important role in medical sciences and technology. Nanoparticles such as polymer and metal nanoparticles are widely used in applications for antioxidant activity. Nonenzymatic antioxidant assays using free radical–scavenging activity of nanoparticles have been investigated using different methods such as 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) assays, nitric oxide radical inhibition assays, superoxide anion–scavenging activity, reducing power, determination of total phenolic compounds and hydroxyl radical–scavenging assays. The investigated metal nanoparticle included gold, zinc oxide, copper, silver, zirconium oxide and selenium, and the polymer nanoparticles include chitosan and silica.


Metal nanoparticles Antioxidant activity Polymers Synthesis Characterization 


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© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Shanmugam Rajeshkumar
    • 1
  • Durairaj Sekar
    • 2
  • Devaraj Ezhilarasan
    • 1
  • Thangavelu Lakshmi
    • 1
  1. 1.Department of Pharmacology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Science (SIMATS)Saveetha UniversityChennaiIndia
  2. 2.Dental Research Cell (DRC-BRULAC), Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Science (SIMATS)Saveetha UniversityChennaiIndia

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