Oxidative Stress and Oral Diseases

  • Aravind Kumar Subramanian
  • Vivek Narayan
  • R. Navaneethan


Oral diseases such as dental caries, lichen planus, oral cancer, and most importantly chronic periodontitis are also believed to be linked to oxidative stress. In periodontitis, the incessant presence of inflammation releases free radicals and via various mechanisms such as DNA damage, lipid peroxidation, protein damage, oxidation of antiproteases, and release of pro-inflammatory cytokines causes free radical-induced damage. The role of free radicals in carcinogenesis has been studied for many decades. The free radicals cause DNA alterations such as mutations, DNA-based oxidation, mutation of tumor suppressor genes, and oxidative protein damage which facilitate the development of oral cancer. The inflammatory infiltrate present in oral lichen planus has CD4+ lymphocytes and is a source of reactive oxygen species which causes cellular damage. Moreover, the saliva itself has an antioxidant system which prevents free radical-mediated damage in certain oral diseases. Hence this chapter is intended to provide an insight about oxidative stress and its association with various oral diseases.


Oxidative stress Periodontitis Free radicals Oral diseases Oral cancer 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Aravind Kumar Subramanian
    • 1
  • Vivek Narayan
    • 2
  • R. Navaneethan
    • 1
  1. 1.Department of Orthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical SciencesSaveetha UniversityChennaiIndia
  2. 2.Department of Oral Medicine and Radiology, Saveetha Dental College, Saveetha Institute of Medical and Technical SciencesSaveetha UniversityChennaiIndia

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