Invasive Mammary Carcinoma
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Breast cancer is the commonest cause of cancer-related deaths in women globally. It is seen to affect average 1 in every 8 women (12% lifetime risk in average risk population). Invasive mammary carcinoma is of two types: ductal or lobular type and these may further show various histological subtypes. Invasive ductal carcinomas show invasion of tumor cells beyond basement membrane. The commonest variety is the no special type (NST) or not otherwise specified (NOS). Special types like medullary, mucinous, and tubular carcinoma are seen in 10%. ILC is more common in older age group and represents about 8–10% of all breast cancers. ILC invades surrounding breast tissue in “single cell fashion” without invoking much desmoplastic tissue reaction and often coexists with lobular neoplasia (LCIS and ALH).
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