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Autophagy and Viral Infection

  • Jingrong Mao
  • Eena Lin
  • Lian He
  • Jiaming Yu
  • Peng TanEmail author
  • Yubin ZhouEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1209)

Abstract

Autophagy is an intracellular recycling process that maintains cellular homeostasis by orchestrating immunity upon viral infection. Following viral infection, autophagy is often initiated to curtail infection by delivering viral particles for lysosomal degradation and further integrating with innate pattern recognition receptor signaling to induce interferon (IFN)-mediated viral clearance. However, some viruses have evolved anti-autophagy strategies to escape host immunity and to promote viral replication. In this chapter, we illustrate how autophagy prevents viral infection to generate an optimal anti-viral milieu, and then concentrate on how viruses subvert and hijack the autophagic process to evade immunosurveillance, thereby facilitating viral replication and pathogenesis. Understanding the interplays between autophagy and viral infection is anticipated to guide the development of effective anti-viral therapeutics to fight against infectious diseases.

Keywords

Autophagy Viral infection Immune response Viral replication 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Institute of Biosciences and Technology, College of MedicineTexas A&M UniversityHoustonUSA
  2. 2.Xiangya HospitalCentral South UniversityChangshaPeople’s Republic of China
  3. 3.Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouPeople’s Republic of China

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