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Autophagy Regulation of Bacterial Pathogen Invasion

  • Yuqing Lei
  • Huihui Li
  • Kefeng LuEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1209)

Abstract

Autophagy pathway is highly conserved in all eukaryotic species and responsible for targeting of cytosol components, such as protein aggregates, damaged or unnecessary organelles, and intracellular bacterial pathogens for lysosome-dependent degradation. Besides severing as a catabolic process, autophagy pathway furthermore has been discovered to function pivotally in both innate and adaptive immune responses. At present, it has been well demonstrated that certain types of bacteria could be targeted by autophagy upon their invasion. However, several bacterial pathogens have developed strategies to evade this degradation and clearance. Here, we review the role and mechanism of autophagy in the regulation of bacteria invasion, which may facilitate the designing of clinical drugs for efficient and safe cure of infection diseases caused by toxic bacteria.

Keywords

Autophagy Bacteria Invasion Degradation Exnophagy 

Notes

Acknowledgments

The authors thank members from K.F. Lu laboratory for advice and help in preparing the manuscript. The K.F. Lu laboratory was supported by the National Key R&D Program of China under grant 2017YFA0506300 (to K.L.) and the National Natural Science Foundation under grants 31770820 (to K.L.).

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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Neurosurgery, State Key Laboratory of Biotherapy, Collaborative Innovation Center for BiotherapyWest China Hospital, Sichuan UniversityChengduChina
  2. 2.State Key Laboratory of BiotherapyWest China Second University Hospital, Sichuan UniversityChengduChina

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