Ca(2+) Ion and Autophagy

  • Yang-Xi Hu
  • Xiao-Shuai Han
  • Qing JingEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1206)


Controlled by a strict mechanism, intracellular calcium (Ca(2+)) is closely related to various cellular activities, including the regulation of autophagy. Researchers believed that under normal or stress state, Ca(2+) has a positive or negative regulation effect on autophagy, the mechanisms of which are different. This bidirectional role of Ca(2+), promotive or suppressing in the regulation of autophagy under different conditions remains controversial, so as the potential mechanisms. Several studies reported that Ca(2+) promotes autophagy through plenty of ways, like inositol 1,4,5-trisphosphate receptor (IP3R) and beclin1 pathway, calmodulin-dependent kinase kinase beta (CaMKKβ)–AMPK–mTOR pathway, mitochondrial energy metabolism-related Ca(2+) uptake, lysosome’s regulation of Ca(2+) signal, and so on. Others thought Ca(2+) may inhibit autophagy through IP3R and beclin1–Bcl-2 complex and the AMPK–mTOR pathway, either. It seems to be still a long way to thoroughly understand the truth of Ca(2+) and autophagy.


Calcium Ca(2+) Autophagy IP3R AMPK 



Cytoplasmic calcium concentration


Endoplasmic reticulum calcium concentration


2-Aminoethoxydiphenyl borate


Adenosine monophosphate


Adenosine 5′-monophosphate (AMP)-activated protein kinase


Autophagy associated gene


Adenosine triphosphate


Calcium ion


Calmodulin-dependent protein kinase kinase


Cyclic adenosine monophosphate


Calcium-induced Ca(2+) release


Death-associated protein kinase


Damage-regulated autophagy modulator


Exchange protein directly activated by cAMP


Green fluorescent protein


Glycine-L-phenylalanine amide-naphthalene


Inositol monophosphatase


1,4,6-inositol triphosphate


1,4,5-inositol triphosphate receptor


Microtubule-associated protein 1 light chain 3


Leucine-rich repeat kinase


Mammalian target of rapamycin


Nicotinic acid adenine dinucleotide phosphate


Nicotinamide adenine dinucleotide


Reduced form of nicotinamide-adenine dinucleotid


Oxygen consumption rate


Pyruvate dehydrogenase


Phospholipase C


Permeability transition pore


Reactive oxygen species


Sarco/endoplasmic reticulum Ca(2+) ATPase


Small interfering RNA


Soluble N-ethylmaleimide-sensitive factor attachment protein receptor


Two-pore channels


Transient receptor potential channel


Transient receptor potential channel, mucolipin subfamily


Uncoordinated 51-like kinase


Voltage-dependent anion-selective channel


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Copyright information

© Science Press and Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of CardiologyShanghai Changhai HospitalShanghaiChina
  2. 2.CAS Key Lab of Tissue Microenvironment and TumorShanghai Institute of Nutrition and Health, Chinese Academy of SciencesShanghaiChina

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