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Ca(2+) Ion and Autophagy

  • Yang-Xi Hu
  • Xiao-Shuai Han
  • Qing JingEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1206)

Abstract

Controlled by a strict mechanism, intracellular calcium (Ca(2+)) is closely related to various cellular activities, including the regulation of autophagy. Researchers believed that under normal or stress state, Ca(2+) has a positive or negative regulation effect on autophagy, the mechanisms of which are different. This bidirectional role of Ca(2+), promotive or suppressing in the regulation of autophagy under different conditions remains controversial, so as the potential mechanisms. Several studies reported that Ca(2+) promotes autophagy through plenty of ways, like inositol 1,4,5-trisphosphate receptor (IP3R) and beclin1 pathway, calmodulin-dependent kinase kinase beta (CaMKKβ)–AMPK–mTOR pathway, mitochondrial energy metabolism-related Ca(2+) uptake, lysosome’s regulation of Ca(2+) signal, and so on. Others thought Ca(2+) may inhibit autophagy through IP3R and beclin1–Bcl-2 complex and the AMPK–mTOR pathway, either. It seems to be still a long way to thoroughly understand the truth of Ca(2+) and autophagy.

Keywords

Calcium Ca(2+) Autophagy IP3R AMPK 

Abbreviations

[Ca(2+)]cyt

Cytoplasmic calcium concentration

[Ca(2+)]ER

Endoplasmic reticulum calcium concentration

2-APB

2-Aminoethoxydiphenyl borate

AMP

Adenosine monophosphate

AMPK

Adenosine 5′-monophosphate (AMP)-activated protein kinase

Atg

Autophagy associated gene

ATP

Adenosine triphosphate

Ca(2+)

Calcium ion

CaMKK

Calmodulin-dependent protein kinase kinase

cAMP

Cyclic adenosine monophosphate

CICR

Calcium-induced Ca(2+) release

DAPK

Death-associated protein kinase

DRAM

Damage-regulated autophagy modulator

Epac

Exchange protein directly activated by cAMP

GFP

Green fluorescent protein

GPN

Glycine-L-phenylalanine amide-naphthalene

IMPase

Inositol monophosphatase

IP3

1,4,6-inositol triphosphate

IP3R

1,4,5-inositol triphosphate receptor

LC3

Microtubule-associated protein 1 light chain 3

LRRK

Leucine-rich repeat kinase

mTOR

Mammalian target of rapamycin

NAADP

Nicotinic acid adenine dinucleotide phosphate

NAD

Nicotinamide adenine dinucleotide

NADH

Reduced form of nicotinamide-adenine dinucleotid

OCR

Oxygen consumption rate

PDH

Pyruvate dehydrogenase

PLC

Phospholipase C

PTP

Permeability transition pore

ROS

Reactive oxygen species

SERCA

Sarco/endoplasmic reticulum Ca(2+) ATPase

siRNA

Small interfering RNA

SNAREs

Soluble N-ethylmaleimide-sensitive factor attachment protein receptor

TPCs

Two-pore channels

TRP

Transient receptor potential channel

TRPML

Transient receptor potential channel, mucolipin subfamily

ULK

Uncoordinated 51-like kinase

VDAC

Voltage-dependent anion-selective channel

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Copyright information

© Science Press and Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of CardiologyShanghai Changhai HospitalShanghaiChina
  2. 2.CAS Key Lab of Tissue Microenvironment and TumorShanghai Institute of Nutrition and Health, Chinese Academy of SciencesShanghaiChina

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