Regulation of Autophagy by mTOR Signaling Pathway

  • Ying Wang
  • Hongbing ZhangEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1206)


Autophagy plays a crucial role in maintaining cellular homeostasis, and is closely related to the occurrence of variety of human diseases. It is known that autophagy occurs in response to various environmental stresses such as nutrient deficiency, growth factor deficiency, and hypoxia. Induced autophagy eliminates the damage caused by these stresses and returns to normal levels when the stresses are relieved. To comprehend the induction of autophagy under various stress conditions and the effects of autophagy on the life processes of cells, it is necessary to understand how autophagy is regulated. Many studies have shown that a number of signal transduction pathways are involved in the regulation of autophagy. Among these pathways, some pathways converge at the target of rapamycin (TOR), a highly conserved kinase important for autophagy regulation. This review will focus on the role of TOR signaling pathway in the regulation of autophagy.


TOR Autophagy Regulation 



v-akt murine thymoma viral oncogene homolog


Autophagy/beclin-1 regulator 1


AMP-activated protein kinase


Adenosine diphosphate ribosylation factor 1


Autophagy-related genes


Death-associated protein 1


FK506-binding protein, 12 kDa molecular weight


FKBP12-Rapamycin Binding


Guanine exchange factor


Histone acetyltransferase


Insulin-like growth factor1


Insulin receptor substrates


Microphthalmia-associated transcription factor


Mammalian target of rapamycin, which has been renamed as mechanistic target of rapamycin


3-Phosphoinositide-dependent protein kinase 1


3-Phosphoinositide-dependent protein kinase 2


Phosphatidylinositol 3-kinase ClassI


Phosphatidylinositol 3-kinase Class III


Phosphoinositide 3-kinase-related kinase


RB1-inducible coiled-coil protein 1


Regulated in development and DNA damage 1


Transcription factor EB


Transcription factor E3


Target of rapamycin


Target of rapamycin complex 1


Target of rapamycin complex 2


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Copyright information

© Science Press and Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Physiology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeInstitute of Basic Medical SciencesBeijingChina
  2. 2.Department of Molecular OrthopedicsBeijing Research Institute of Traumatology and OrthopaedicsBeijingChina

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