Chitosan-Based Systems in Tissue Engineering
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Chitosan is a unique, naturally obtained polysaccharide derived from chitin. As a biomaterial, it attains immense interest for tissue engineering due to its biocompatibility and biodegradation which also exhibits desired properties such as bactericidal, fungicidal, and enhanced immune activity. Chitosan-based materials are mainly focused on fabricating scaffolds for tissue engineering. The ideal features of scaffolds are three-dimensional, highly porous, biocompatible, and bioresorbable, with cell attachment, proliferation, and implantation. Especially, these scaffolds have distinctive advantages, such as preservation of cellular binding and bioactive factor enrichment. This chapter highlights chitosan-based scaffolds and its composites having higher potential to be employed in bone, cartilage, liver, nerve, and musculoskeletal tissue engineering.
KeywordsChitosan Tissue engineering Biomaterials and scaffolds
The authors wish to acknowledge the DST-sponsored National Facility for Drug Development (VI-D&P/349/10-11/TDT/1), Nanomission program of the Department of Science and Technology (DST), Ministry of Science and Technology of India (DST/SR/NM/NS-19/2009), and Technical Education Quality Improvement Programme (TEQIP-PHASE II) for their support in this work.
- Cigdem Arca H, Senel S (2008a) Chitosan based systems for tissue engineering part I: soft tissues. FABAD J Pharm Sci 33:211–216Google Scholar
- Cigdem Arca H, Senel S (2008b) Chitosan based systems for tissue engineering part II: hard tissues. FABAD J Pharm Sci 33:35–49Google Scholar
- Hunter W (1743) On the structure and diseases of articulating cartilages. Philos Trans R Soc Lond 42:514–521Google Scholar
- Kane RJ, Roeder RKJ (2012) Mechanical behaviour effects of hydroxyapatite reinforcement on the architecture and mechanical properties of freeze-dried collagen scaffolds. Biomed Mater 7:41–49Google Scholar
- Maria VR (2006) Revisiting ceramics for medical applications. Dalton Trans 44:5211–5220Google Scholar
- Raymund HE (2012) New developments and trends in tissue engineering: an update. J Tissue Sci Eng 3(2):e110Google Scholar
- Ruiz EH, Ariga K, Lvov Y (2008) Bioinorganic Hybrid Nanomaterials. Weinheim, Wiley-VCH Verlag GmbH & Co. KGaAGoogle Scholar
- Sanchez C, Ribot F (1994) Design of hybrid organic–inorganic materials synthesized via sol-gel chemistry. New J Chem 18:1007–1047Google Scholar