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Pharmacological Preconditioning

  • Shinya Minatoguchi
Chapter
First Online:

Abstract

In a clinical setting, pharmacological preconditioning is a practical way to protect the heart against ischemia-reperfusion injury. There are many kinds of drugs which may protect the heart against acute myocardial infarction when used before the onset of acute myocardial infarction. Some of these drugs show beneficial effects through the mechanism of ischemic preconditioning but others show beneficial effects through mechanisms different from ischemic preconditioning. Drugs such as the Katp channel opener, α-glucosidase inhibitors, DPP-IV inhibitor, thiazolidine antidiabetic, Ca-channel blockers, β-blockers, HMG-CoA reductase inhibitor, anti-platelets, ARBs, and ACE inhibitors show pharmacological preconditioning effects on the myocardial infarct size and cardiac function, and the precise mechanisms leading to the beneficial effects of these drugs are discussed.

Keywords

Pharmaciological preconditioning Myocardial infarct size Cardiac function 
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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Shinya Minatoguchi
    • 1
  1. 1.Head of Heart Failure Center, Gifu Municipal HospitalEmeritus Professor, Gifu University Graduate School of MedicineGifuJapan

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