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Ischemic Preconditioning

  • Shinya Minatoguchi
Chapter

Abstract

Brief episodes of ischemia and reperfusion precondition the myocardium and reduce the infarct size and following sustained ischemia. This phenomenon is termed as ischemic preconditioning (PC). PC is a powerful endogenous protection and has been demonstrated in dogs, pigs, rabbits and rats and humans. This protection is characterized as a reduction of infarct size and an improvement of postischemic cardiac dysfunction.

Keywords

Brief episodes of ischemia and reperfusion Ischemic preconditioning Infarct size 

References

  1. 1.
    Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 1986; 74: 1124–36.CrossRefGoogle Scholar
  2. 2.
    Yellon DM, Alkhulaifi AM, Browne EE and Pugsley WB. Ischaemic preconditioning limits infarct size in the rat heart. Cardiovasc Res 1992; 26: 983–987.CrossRefGoogle Scholar
  3. 3.
    Liu GS, Thornton J, Van Winkle DM, Stanley AWH, Olsson RA and Downey JM. Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart. Circulation 1991; 84: 350–356.CrossRefGoogle Scholar
  4. 4.
    Scott RJ, Rohmann S, Braun ER and Schaper W. Ischemic preconditioning reduces infarct size in swine myocardium. Circ Res 1990; 66: 1133–1142.CrossRefGoogle Scholar
  5. 5.
    Noda T, Minatoguchi S, Fujii K, Hori M, Ito T, Kanmatsuse K, Matsuzaki M, Miura T, Nonogi H, Tada M, Tanaka M, Fujiwara H. Evidence for the delayed effect in human ischemic preconditioning. J Am Coll Cardiol 1999; 34: 1966–74.CrossRefGoogle Scholar
  6. 6.
    Eisen A, Fisman EZ, Rubenfire M, Freimark D, McKechnie R, Tenenbaum A, Motro M, Adler Y. Ischemic preconditioning: nearly two decades of research. A comprehensive review. Atherosclerosis 2004; 172: 201–210.CrossRefGoogle Scholar
  7. 7.
    Ottani F, Galvani M, Ferrini D, Sorbello F, Limonetti P, Pantoli D, Rusticali F. Prodromal angina limit infarct size. A role for ischemic preconditioning. Circulation 1995; 91: 291–7.CrossRefGoogle Scholar
  8. 8.
    Nakagawa Y, Ito H, Kitakaze M, Kusuoka H, Hori M, Kuzuya T, Higashino Y, Fujii K, Minamino T. Effect of angina pectoris on myocardial protection in patients with reperfused anterior wall myocardial infarction: retrospective clinical evidence of “preconditioning”.” J Am Coll Cardiol 1995; 25: 1076–83.CrossRefGoogle Scholar
  9. 9.
    Thornton JD, Liu GS, Olsson RA, Downey JM. Intravenous pretreatment with A1-selective adenosine analogues protects the heart against infarction. Circulation 1992; 85: 659–65.CrossRefGoogle Scholar
  10. 10.
    Mahiko G, Liu Y, Yang XM, Ardell JL, Cohen MV, Downey JM. Role of bradykinin in protection of ischemic preconditioning in rabbit hearts. Circ Res 1995; 77: 611–621.CrossRefGoogle Scholar
  11. 11.
    Wang GY, Wu S, Pei JM, Yu XC, Wong TM. Kappa- but not delta-opioid receptors mediate effects of ischemic preconditioning on both infarct and arrhythmia in rats. Am J Physiol Heart Circ Physiol 2001; 280: H384–91.CrossRefGoogle Scholar
  12. 12.
    Bankwara Z, Hale SL, Kloner RA. α-Adrenoceptor stimulation with exogenous norepinephrine or release of endogenous catecholamines mimics ischemic preconditioning. Circulation 1994; 90: 1023–8.CrossRefGoogle Scholar
  13. 13.
    Tsuchida A, Liu Y, Liu GS, Choen MV, Downey JM. α1-adrenergic agonist precondition rabbit ischemic myocardium independent of adenosine by direct activation of protein kinase C. Circ Res 1994; 75: 576–585.CrossRefGoogle Scholar
  14. 14.
    Kariya T, Minatoguchi S, Ohno T, Yamashita K, Uno Y, Arai M, Koshiji M, Fujiwara T, Fujiwara H. Infarct size-reducing effect to ischemic preconditioning is related to α1b-adrenoceptors but not to α1a-adrenoceptors in rabbits. J Cardiovasc Pharmacol 1997; 30: 437–445.CrossRefGoogle Scholar
  15. 15.
    Tanaka M, Fujiwara H, Yamasaki K, Sasayama S. Superoxide dismutase and N-2-mercaptopropionyl glycine attenuate infarct size limitation effect of ischaemic preconditioning in the rabbit. Cardiovasc Res 1994; 28: 980–6.CrossRefGoogle Scholar
  16. 16.
    Ytrehus K, Liu Y and Downey J. Preconditioning protects ischemic rabbit heart by protein kinase C activation. Am J Phys 1994; 266: H1145-H1152.Google Scholar
  17. 17.
    Gross GJ, Auchampach J. Blockade of ATP-sensitive potassium channels prevent myocardial preconditioning in dogs. Circ Res 1992; 70: 223–33.CrossRefGoogle Scholar
  18. 18.
    Hide EJ, Thiemermann C. Limitation of myocardial infarct size in the rabbit by ischaemic preconditioning is abolished by sodium 5-hydroxydecanoate. Cardiovasc Res 1996; 31: 941–946.CrossRefGoogle Scholar
  19. 19.
    The IONA Study Group. Effect of nicorandil on coronary events in patients with stable angina: the impact of Nicorandil in Angina (IONA) randomized trial. Lancet 2002; 359: 1269–1275.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Shinya Minatoguchi
    • 1
  1. 1.Head of Heart Failure Center, Gifu Municipal HospitalEmeritus Professor, Gifu University Graduate School of MedicineGifuJapan

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