Skin Cancer

  • Nikhil P. JoshiEmail author
  • Martin C. Tom


Skin cancer is one of the commonest malignancies seen in humans and occurs predominantly in the Caucasian population. Exposure to UV radiation is a common etiology. This chapter will focus on primary invasive squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) of the skin. A detailed discussion of other skin cancers (melanoma, Merkel cell carcinoma, and other rare skin tumors) is beyond the scope of this chapter. This chapter focuses on history, examination, evaluation, and management of skin cancers with an emphasis on the role of radiation.


Skin cancer Squamous cell carcinoma Basal cell carcinoma Radiotherapy 


  1. 1.
    Manyam BV, Garsa AA, Chin RI, et al. A multi-institutional comparison of outcomes of immunosuppressed and immunocompetent patients treated with surgery and radiation therapy for cutaneous squamous cell carcinoma of the head and neck. Cancer. 2017;123(11):2054–60.CrossRefGoogle Scholar
  2. 2.
    Manyam BV, Gastman B, Zhang AY, et al. Inferior outcomes in immunosuppressed patients with high-risk cutaneous squamous cell carcinoma of the head and neck treated with surgery and radiation therapy. J Am Acad Dermatol. 2015;73(2):221–7.CrossRefGoogle Scholar
  3. 3.
    Edge SB, American Joint Committee on Cancer. AJCC cancer staging manual. 8th ed. New York: Springer; 2017.Google Scholar
  4. 4.
    Karia PS, Jambusaria-Pahlajani A, Harrington DP, Murphy GF, Qureshi AA, Schmults CD. Evaluation of American Joint Committee on Cancer, International Union Against Cancer, and Brigham and Women’s Hospital tumor staging for cutaneous squamous cell carcinoma. J Clin Oncol. 2014;32(4):327–34.CrossRefGoogle Scholar
  5. 5.
    Migden MR, Rischin D, Schmults CD, et al. PD-1 blockade with cemiplimab in advanced cutaneous squamous-cell carcinoma. N Engl J Med. 2018;379(4):341–51.CrossRefGoogle Scholar
  6. 6.
    Harris BN, Pipkorn P, Nguyen KNB, et al. Association of adjuvant radiation therapy with survival in patients with advanced cutaneous squamous cell carcinoma of the head and neck. JAMA Otolaryngol Head Neck Surg. 2019;145:153.CrossRefGoogle Scholar
  7. 7.
    Koyfman SA, Cooper JS, Beitler JJ, et al. ACR appropriateness criteria((R)) aggressive nonmelanomatous skin cancer of the head and neck. Head Neck. 2016;38(2):175–82.CrossRefGoogle Scholar
  8. 8.
    Gluck I, Ibrahim M, Popovtzer A, et al. Skin cancer of the head and neck with perineural invasion: defining the clinical target volumes based on the pattern of failure. Int J Radiat Oncol Biol Phys. 2009;74(1):38–46.CrossRefGoogle Scholar
  9. 9.
    Burmeister BH, Mark Smithers B, Burmeister E, et al. A prospective phase II study of adjuvant postoperative radiation therapy following nodal surgery in malignant melanoma-Trans Tasman Radiation Oncology Group (TROG) Study 96.06. Radiother Oncol. 2006;81(2):136–42.CrossRefGoogle Scholar
  10. 10.
    Aberle DR, Adams AM, Berg CD, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011;365(5):395–409.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  1. 1.Cleveland Clinic FoundationClevelandUSA

Personalised recommendations