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Altered Fractionation Radiotherapy

  • Supriya Mallick
  • Goura K. Rath
Chapter

Abstract

Fractionation is a very important aspect of delivering radiation to the tumor to attain maximum tumor control and with minimal toxicity to the normal tissues. Conventional fractionation refers to delivering radiation at daily fractions of 1.8–2.0 Gy, delivered 5 days of a week for a total of 6–7 weeks. Hyper-fractionation, accelerated fractionation, and hypo-fractionation are the common altered fractionation schedules used clinically. The chapter describes the radiobiology, benefits, and clinical evidence for various altered fractionation schedules.

Keywords

Hyper-fractionation Accelerated fractionation Hypo-fractionation 

References

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    Haviland JS, Owen JR, Dewar JA, Agrawal RK, Barrett J, Barrett-Lee PJ, et al. The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials. Lancet Oncol. 2013;14(11):1086–94.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Supriya Mallick
    • 1
  • Goura K. Rath
    • 1
  1. 1.Department of Radiation OncologyNational Cancer Institute-India (NCI-India)JhajjarIndia

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