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Stem Cell Therapy: A Great Leap Forward in Alzheimer’s Treatment

  • Nazish Tabassum
  • Chandra Bhan Yadav
  • Anshuman Singh
  • Vinod VermaEmail author
Chapter

Abstract

Alzheimer’s disease (AD) is a neurodegenerative disorder and one of the substantial socioeconomic and medical calamities of our time. It is characterized by progressive neurodegenerative disorder featuring dementia and cognitive impairment. It is caused by synaptic failure and the excessive aggregation of two types of misfolded proteins, namely, amyloid-β (Aβ) and tau protein. AD is a complex disease that affects neurons in different parts of the brain. The treatment of AD is difficult with currently available medications and treatment approaches due to inadequate knowledge of its etiology and versatile nature of its pathology. Stem cell holds a promising approach to regenerate the tissue systems and has been explored in various studies of neurodegenerative disorders and provides great research opportunity. Stem cell research-based therapies emit a new hope for AD treatment as a regenerative approach. This chapter focuses on recent advances in stem cell therapies according to cell types and pathophysiology of AD along with human clinical trials of stem cell therapies for the AD.

Keywords

Stem cell Alzheimer’s disease Amyloid precursor protein 

Notes

Acknowledgment

This work is supported by SERB (EEQ/2018/000114) grant.

Disclosure of Potential Conflicts of Interest

The author(s) declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Nazish Tabassum
    • 1
  • Chandra Bhan Yadav
    • 1
  • Anshuman Singh
    • 2
  • Vinod Verma
    • 2
    Email author
  1. 1.Centre of Biotechnology, Nehru Science ComplexUniversity of AllahabadAllahabadIndia
  2. 2.Stem Cell Research Centre (SCRC), Department of HematologySanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS)LucknowIndia

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