Cancer: Genetics and Important Pathways
We have seen in Chap. 1 that all the hallmarks of cancer are related to molecular mechanisms in cells, driven by expression levels of key genes. Moreover, these genes are many times connected through genetic pathways. We have discussed the apoptosis pathway in Chap. 1. We start this chapter with a review of the fundamental concepts in genetics and molecular biology. We then discuss the genetic landscape of cancer. It is a complex problem to implicate specific genes for particular types of cancer, and our understanding is evolving all the time. We discuss the current understanding of the genetic landscapes for several important types of cancer. Finally we discuss some of the important pathways involved in cancer.
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